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Öğe Cefuroxime induced leukocytoclastic vasculitis: a case report(Wiley-Blackwell, 2011) Akkelle, E.; Yazicioglu, M.; Cetinkaya, E.; Ozkayin, N.; Yalcin, O.[Abstract Not Available]Öğe The effects of Enalapril and Irbesartan in experimental diabetic nephropathy(Diagnosis Press Ltd, 2007) Yalcin, O.; Ustundag, S.; Sen, S.; Usta, U.; Huseyinova, G.; Puyan, F. Oz; Kutlu, K.In our study we investigated the effects of angiotensin converting enzyme inhibitor and Angiotensin T, receptor blocker at low-doses which do not affect blood pressure and renal hemodynamia on the experimental diabetic nephropathy. Diabetes mellitus was induced by 50 mg/kg streptozotocin on Sprague-Dawley rats. Except for the patient control group, 2.5 mg/kg Enalapril (an angiotensin converting enzyme inhibitor) and 5 mg/kg Irbesartan (an Angiotensin T, receptor blocker) were given everyday via drinking water during six weeks period. After 24-hour urine collection, blood was withdrawn by cardiac puncture, and rats were sacrificed. Renal functions, histopathologic and electron microscopic alterations in renal tissues, and relative percent deposition of type IV Collagen were investigated. Diabetic nephropathy was determined with the increase of plasma glucose, HbA(9)C (P< 0. 000), urea, creatinin (P<0.005) and urinary protein, albumin, glucose (P<0. 000) inpatient control and Enalapril and Irbesartan treatment groups when compared to the healthy control group. Mesangiocellular proliferation, tubular basement membrane thickness, percentage of glomerular collagen accumulation reduced in treatment groups and glucose in urine in Enalapril group declined. Our findings suggest that renal protective effects of Enalapril and Irbesartan in the development of diabetic nephropathy were comparable.Öğe Histopathological and biochemical comparisons of the protective effects of amifostine and L-carnitine against radiation-induced acute testicular toxicity in rats(Wiley, 2017) Aktoz, T.; Caloglu, M.; Yurut-Caloglu, V.; Yalcin, O.; Aydogdu, N.; Nurlu, D.; Arda, E.The aim of this study was to compare the radioprotective efficacies of amifostine (AMI) and L-carnitine (LC) against radiation-induced acute testicular damage. Thirty Wistar albino rats were randomly assigned to four groups: control (n = 6), AMI plus radiotherapy (RT) (n = 8), LC plus RT (n = 8) and RT group (n = 8). The rats were irradiated with a single dose of 20 Gy to the scrotal field. LC (300 mg/kg) and AMI (200 mg/kg) were given intraperitoneally 30 min before irradiation. The mean seminiferous tubule diameters (MSTDs) were calculated. Testicular damage was evaluated histopathologically using Johnsen's mean testicular biopsy score criteria. Malondialdehyde (MDA) and glutathione levels were measured in tissue samples. AMI plus RT and LC plus RT groups had significantly higher MSTDs than those in the RT group (p =.003 and p =.032 respectively). MDA values of both AMI plus RT and LC plus RT groups were significantly lower than those in RT group (p <.004 and p <.012 respectively). As a result, AMI and LC have a similar radioprotective effect against radiation-induced acute testicular damage, histopathologically and biochemically.Öğe Metastases of hepatocellular carcinoma to the costa and soft tissue: A very rare entity(Springer, 2012) Tastekin, E.; Yalta, T. D.; Yalcin, O.; Ciftci, T.[Abstract Not Available]Öğe Non specific magnetic resonance features of chondromyxoid fibroma of the iliac bone(Zerbinis Medical Publ, 2007) Yalniz, E.; Alicioglu, B.; Yalcin, O.; Yilmaz, B.Chondromyxoid fibroma is a benign cartilaginous neoplasm. The tumor is rare, perhaps the rarest of all bone tumors. It is more common in long bones and rare in pelvic bones. We report a case of a 31-year-old woman with chondromyxoid fibroma arising from the iliac bone and presenting with leg pain due to compression on the femoral nerve. Magnetic resonance imaging (MRI) features were non specific for chondromyxoid fibroma. We emphasize the need to consider differential diagnosis of chondrosarcoma.Öğe Penile and scrotal involvement in Buerger's disease(Wiley-Blackwell Publishing, Inc, 2008) Aktoz, T.; Kaplan, M.; Yalcin, O.; Atakan, I. H.; Inci, O.Buerger's disease (thromboangiitis obliterans) is a recurrent inflammatory, nonatherosclerotic vasoocclusive disease, which typically affects small and medium-sized arteries, veins and nerves of the upper and lower extremities. Although the exact underlying causes of Buerger's disease are still unknown, the disease is strongly associated with tobacco smoking. Affected patients are mostly young male smokers who develop ulcers and gangrene of the toes and fingers as a result of vascular ischaemia. We report a 47-year-old man with scrotal and penile necrosis. Partial penectomy, scrotal debridement and urethra-cutaneous anastomosis were performed.Öğe PROTECTIVE EFFECTS OF AMIFOSTINE AND L-CARNITINE AGAINST RADIATION INDUCED ACUTE TESTICULAR TOXICITY(Elsevier Ireland Ltd, 2012) Caloglu, M.; Aktoz, T.; Caloglu, V. Yurut; Yalcin, O.; Aydogdu, N.; Nurlu, D.; Arda, E.[Abstract Not Available]Öğe Stevens-Johnson syndrome: a case report(Blackwell Publishing, 2008) Yazicioglu, M.; Yscan, B.; Turgut, B.; Yalcin, O.[Abstract Not Available]Öğe Stevens-Johnson syndrome: a case report [Letter](Elsevier Doyma Sl, 2009) Yazicioglu, M.; Iscan, B.; Turgut, B.; Yalcin, O.[Abstract Not Available]Öğe Un-methylation of the survivin gene has no effect on immunohistochemical expression of survivin protein in lung cancer patients with squamous cell carcinoma(Comenius Univ, 2017) Yalcin, O.; Budak, M.Survivin is a member of the inhibitor of apoptosis (IAP) family. The function of the survivin protein is to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by the disruption of survivin induction pathways leading to an increased apoptosis and decreased tumour growth. These data suggest that survivin may provide a new target for cancer treatment, which would distinguish transformed cells from normal cells. In the present study, we aimed to investigate exon 1 of the survivin gene by means of methylation-specific PCR and evaluate its impact on survivin protein expression following DNA isolation and bisulphite modification in paraffin-embedded normal and tumour tissues of lung cancer patients with squamous cell carcinoma. We used 41 squamous cancer tissues with methylation in exon 1 of the survivin gene and non-methylation in corresponding tumours. However, the immunohistochemistry staining of these samples demonstrated an increased survivin protein compared to normal tissue. While there is almost no other study to date on this subject matter, we believe that the absence of methylation in exon 1 of the survivin gene may not affect disease prognosis as it has no effect on expression, and possible promoter methylation or transcription factors (Tab. 1, Fig. 4, Ref. 15). Text in PDF www.elis.sk.
