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Öğe Aortic aneurysm and electroconvulsive therapy in elderly depressive patient(Lippincott Williams & Wilkins, 2003) Caliyurt, O; Tuglu, C; Vardar, EWe report the case of a 67-year-old single man with aortic aneurysm whose depression was successfully treated with electroconvulsive therapy. Metoprolol succinate was used for blood pressure control, and there were no cardiovascular side effects and no significant increase in blood pressure detected.Öğe Combination therapy using sertraline with sleep deprivation and light therapy compared to sertraline monotherapy for major depressive disorder(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2005) Güdücü, F; Çaliyurt, O; Vardar, E; Tuglu, C; Abay, EObjective: Bright light therapy is effective and well tolerated in seasonal affective disorder and some studies reported an antidepressant effect of bright light also in non-seasonal depression. On the other hand, total sleep deprivation leads to a rapid and marked improvement of mood in 60% of depressed patients. Combinations of antidepressant medication with those somatic therapies are generally indicated. The aim of this study was to compare the efficacy of the combination of sertraline and partial sleep deprivation or light therapy with sertraline monotherapy in the treatment of major depression. Method: Thirty-seven patients with major depressive disorder were randomly allocated into 3 treatment groups. Thirteen were treated with sertraline and late partial sleep deprivation, 13 with sertraline and bright light therapy and 11 sertaline monotherapy as a control group. Outcome measures included daily (first 15 days) and weekly Hamilton Rating Scale for Depression and biweekly Hamilton Anxiety Rating Scale. Results: Partial sleep deprivation group improved significantly and more rapidly. Accelerated treatment response was shown in sleep deprivation group that improvement was observed after the third day. Bright light and sleep deprivation combinations with sertraline were more effective than sertraline monotherapy for accompanied anxiety in depression. Conclusion: Late partial sleep deprivation in combination with sertraline can accelerate and increase the treatment response in non-seasonal major depressive disorder.Öğe Comparison of regional cerebral blood flow in early and late onset alcoholic patients(Springer, 2004) Vardar, E; Durmus-Altun, G; Erdogan, E; Firat, MF; Tuglu, C; Caliyurt, O; Abay, E[Abstract Not Available]Öğe Cotard's syndrome with schizophreniform disorder can be successfully treated with electroconvulsive therapy: case report(Cma-Canadian Medical Assoc, 2004) Caliyurt, O; Vardar, E; Tuglu, CWe report a case of Cotard's syndrome associated with psychotic symptoms. A 27-year-old man was admitted to hospital with the diagnosis of schizophreniform disorder. His presenting symptoms, which had started 1 month before hospital admission, were somatic delusions of gastrointestinal and cardiovascular malfunction and the absence of a stomach, which resulted in a decrease in weight from 75 kg to 63 kg in 1 month. Cranial computed tomographic images showed dilatation of the lateral and third ventricles, whereas magnetic resonance imaging revealed central atrophy and lateral ventricle dilatation. Single-photon emission computed tomography demonstrated left temporal, left frontal and left parietal hypoperfusion. The patient did not respond to antipsychotic therapies, but he was successfully treated with electroconvulsive therapy. This report emphasizes that Cotard's syndrome may be accompanied by lesions of the left hemisphere and that electroconvulsive therapy could be the first-line therapy in such patients with psychotic disorder.Öğe Effects of sertraline and venlafaxine on serum TNF-? in major depressive disorder(Elsevier Science Bv, 2003) Tuglu, C; Kara, H; Caliyurt, O; Vardar, E; Abay, E[Abstract Not Available]Öğe Evaluation of the prevalence rates and comorbidity of eating disorders in high school students in central Edirne city(Elsevier Science Bv, 2005) Vardar, E; Erzengin, M; Abay, E[Abstract Not Available]Öğe Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder(Springer, 2003) Tuglu, C; Kara, SH; Caliyurt, O; Vardar, E; Abay, ERationale. Over the last 15 years, an increasing body of evidence has suggested a causal relationship between depression and the immunological activation and hypersecretion of pro-inflammatory cytokines, such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha (TNF-alpha). However, little is known about the probable relationship of serum TNF-alpha with major depressive disorder (MDD). Objective. To assess whether serum TNF-alpha levels could be associated with the clinical course of MDD. Subjects and methods. TNF-alpha and C-reactive protein (CRP) serum concentrations, erythrocyte sedimentation rate, and leukocyte count were measured in 26 MDD patients and in 17 controls. The measurements were repeated following 6 weeks of antidepressant treatment with selective serotonin re-uptake inhibitors. Psychopathological improvement and the severity of depression were evaluated with the Hamilton Depression Rating Scale (HAMD) and Beck Depression Inventory (BDI). Results. On admission, serum TNF-alpha and leukocyte count were significantly higher in MDD patients compared to controls (P<0.001 and P=0.005, respectively). With the antidepressant treatment, both HAMD and BDI scores decreased significantly (P<0.001 for both). Comparison of pre- and post-treatment measurements revealed that TNF-alpha, CRP, and leukocyte count decreased to levels comparable with those of the control subjects (P<0.001, P=0.01, and P=0.01, respectively). Conclusions. The results emphasized that some immunological parameters, such as CRP, leukocyte count and TNF-alpha, are significantly involved in the clinical course and treatment response in MDD. TNF-alpha in particular could be considered as a potential state marker in MDD.Öğe Prevalence of the female athlete triad in Edirne, Turkey(Journal Sports Science & Medicine, 2005) Vardar, SA; Vardar, E; Altun, GD; Kurt, C; Öztürk, LThe aim of this study was to determine the prevalence of the female athlete triad, which is a clinical condition defined as the simultaneous occurrence of disordered eating, amenorrhea, and osteopenia and/or osteoporosis in female athletes. A total number of 224 female athletes from Edirne city participated in our study. Eating attitudes test ( EAT 40) and a self-administered questionnaire were used to assess disordered eating behavior and menstrual status respectively. The participants having both disordered eating and amenorrhea were performed dual energy x-ray absorptiometry to evaluate bone mineral density. Thirty seven subjects (16.8%) had disordered eating behavior and 22 subjects (9.8%) were reported to have amenorrhea. Six athletes (2.7%) met two criteria ( disordered eating and amenorrhea) of the triad. Of these, only three athletes met all components of the triad. We have found that the prevalence rate of female athlete triad was 1.36% among young Turkish female athletes. Female athletes have under considerable risk for the disordered eating and amenorrhea components of the triad.Öğe Sleep quality and psychopathological features in obese binge eaters(Wiley, 2004) Vardar, E; Caliyurt, O; Arikan, E; Tuglu, CThe objectives of this study were to determine the prevalence of Binge Eating Disorder (BED) and to investigate the subjective sleep qualities and the psychopathological features of BED in treatment-seeking obese patients. Thirty-six treatment-seeking obese subjects and 37 control subjects were interviewed with the DSM-IV research criteria for BED, The Pittsburgh Sleep Quality Index (PSQI), Bulimic Investigatory Test, Edinburg (BITE) and SCL-90-R scales. Eight out of 36 treatment-seeking obese patients (22.2 per cent) met the criteria for BED. The PSQI global scores, sleep latencies and SCL-PSDI, SCL-interpersonal sensitivity subscale results were all significantly higher in treatment-seeking BED obese subjects than non-BED (N-BED) subjects and controls. Our findings suggest that BED appears to be a common disorder in treatment-seeking obese patients. The treatment-seeking obese BED patients suffer from more psychopathological problems than N-BED obese patients and controls, and the subjective sleep qualities are likely to be disrupted in patients with BED. Copyright (C) 2004 John Wiley Sons, Ltd.
