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Öğe The effect of low-dose external beam radiation on extraneural scarring after peripheral nerve surgery in rats(Lippincott Williams & Wilkins, 2003) Görgülü, A; Uzal, C; Doganay, L; Imer, M; Eliuz, K; Çobanoglu, SOBJECTIVE: Scar tissue is an inevitable result of peripheral nerve surgery. A variety of substances have been used to prevent epineurial scarring. In this study, the effect of low-dose radiation therapy on epineurial scarring was investigated. METHODS: Seventy-eight male Sprague-Dawley rats were studied. A total of 60 rats were subjected to one of three types of surgical procedure on the sciatic nerve, as follows: Procedure 1, external neurolysis (n = 20); Procedure 2, abrasive injury (n = 20); and Procedure 3, anastomosis (n = 20). On the left sciatic nerves, 700 cGy external beam radiation was administered 24 hours after surgery, and the right sciatic nerves served as a control group (surgery only). Eighteen animals without surgical intervention were used to establish the fibrotic effect of radiotherapy on normal nerves. A neurological examination was performed weekly. Six weeks after surgery, the extent of extraneural scarring was examined by gross microdissection by means of a numerical grading scheme and histological analysis. Cellular density and surface measurements of scar tissue were also evaluated. RESULTS: The dissection around the nerve was easier in rats treated with low-dose radiation compared with the control group. Furthermore, grading scores in both nerve adherence and nerve separability were significantly lower in treated nerves than in the control group (P less than or equal to 0.05). Low-dose radiotherapy decreased the scores of cellular density and surface measurement of scar tissue (P less than or equal to 0.05). In normal nerves, radio? therapy did not produce any fibrotic effects and the density of fibroblasts/fibrocytes was also very low. CONCLUSION: In the case of surgery or local trauma to peripheral nerve, the use of low-dose radiation therapy may be a safe method of limiting postoperative epineurial scar formation.Öğe The potential cardioprotective effects of amifostine in irradiated rats(Elsevier Science Inc, 2004) Tokatli, F; Uzal, C; Doganay, L; Kocak, Z; Kaya, M; Ture, M; Kurum, TPurpose: The aim of this study is to determine the cardioprotective efficacy of amifostine. The study consists of researching the relationship between plasma brain natriuretic peptide levels and the electrical and morphologic changes in irradiated rats with or without amifostine. Methods and Materials: Sixty Wistar albino rats were divided into 4 groups, and their hearts were given 15 Gy/fraction with Co-60. In Groups I and II, the rats were killed after 24 hours to detect early effects; in Groups III and IV, the rats were killed 100 days after irradiation to detect late effects. Before irradiation, Groups I and III received 0.9% saline solution, whereas Groups II and IV received amifostine (200 mg/kg). Twenty rats were used as a control group. Results: On the 100th day, mild myocardial degeneration was detected in 5 rats (33%) from Group III (no amifostine). This percentage was statistically different from that of Group IV (treated with amifostine) and the controls (p = 0.042). There was no statistically significant difference between the mean plasma brain natriuretic peptide values of the groups (p > 0.05). There was no significant difference in electrocardiographies between the groups. There was no correlation between continuous variables. Conclusion: In the amifostine group (IV) on the 100th day, there was no myocardial degeneration, suggesting that amifostine has a cardioprotective effect. (C) 2004 Elsevier Inc.Öğe The protective effect of amifostine on radiation-induced acute pulmonary toxicity(Elsevier Science Inc, 2004) Uzal, C; Durmus-Altun, G; Caloglu, M; Ergülen, A; Altaner, S; Yigitbasi, NOPurpose: The purpose of this study was to determine by using Tc-99m-diethylenetriaminepentaacetic acid (DTPA) lung scintigraphy whether amifostine given before irradiation protects alveolocapillary integrity in a rabbit model. Methods and Materials: Twenty white New Zealand rabbits were randomly divided into 4 groups: (1) control (CONT), (2) amifostine alone (AMF), (3) radiation (RAD), and (4) radiation plus amifostine (RAD + AMF). The AMF and RAD + AMF groups received amifostine. The RAD and RAD + AMF groups were irradiated to the right hemithorax with a single dose of 20 Gy using a Co-60 treatment unit. Amifostine (200 mg/kg) was given i.p. 30 min before irradiation. The (99)mTc-DTPA radioaerosol study was performed 14 day after irradiation. Results: The mean clearance rate of Tc-99m-DTPA in control subjects was 140 +/- 21 min. The highest It, value was noted in the RAD group (603 105 min, p = 0.001). There were no significant differences between the Tc-99m-DTPA lung clearance rates of the CONT, RAD + AMF (238 +/- 24 min), and AMF groups (227 +/- 54 min). The mean penetration index values of CONT, RAD, AMF, and RAD + AMF are 63% 1.6%, 63% 2.5%, 60% 2.9%, and 63% 2%, respectively. Conclusions: We concluded that amifostine treatment before the lung irradiation protects the lung alveolocapillary integrity. This study confirms the protective effect of amifostine in an acute phase of radiation lung injury. (C) 2004 Elsevier Inc.Öğe Tc-99m MIBI filling pattern in a photopenic area of a Tc-99m MDP scan in a patient with metastatic bone involvement of breast carcinoma(Lippincott Williams & Wilkins, 2002) Altun, GD; Uzal, C; Hacimahmutoglu, S; Pekindil, G; Sarikaya, A; Yigitbasi, NÖA 71-year-old woman had locally advanced invasive breast cancer in July 1997. She underwent modified radical mastectomy for left breast cancer in October 1997 after she had been treated with six of courses neoadjuvant chemotherapy and local radiation therapy. She was referred for bone scintigraphy due to bone pain in September 1999. The bone scan showed metastatic involvement in the left temporoparietal area as increased Tc-99m MDP uptake with large central photopenia. The computed tomographic (CT) scan of the cranium revealed lytic bone lesions located in the same region, which was irregularly contoured. Tc-99m MIBI imaging was performed 1 week after the bone scan. Increased uptake without central photopenia was observed in the same area as the bone scan abnormality. It was described as a Tc-99m MIBI filling pattern of the photopenic area seen with Tc-99m MDP.Öğe Tc99m MIBI scintigraphy in metastatic bone involvement of breast cancer(Springer-Verlag, 2001) Altun, GD; Uzal, C; Hacimahmutoglu, S; Pekindil, G; Sarikaya, A[Abstract Not Available]
