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Öğe Ciliated hepatic foregut cyst(Springer, 2017) Tutug, B. Binboga; Usta, U.; Can, N.; Genc, E.[Abstract Not Available]Öğe A curious mass of the anterior compartment in the knee(British Inst Radiology, 2009) Demir, M. K.; Unlu, E.; Usta, U.[Abstract Not Available]Öğe Development of primary central nervous system lymphoma in a systemic lupus erythematosus patient after treatment with mycophenolate mofetil and review of the literature(Sage Publications Ltd, 2017) Balci, M. A.; Pamuk, G. E.; Unlu, E.; Usta, U.; Pamuk, O. N.Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma and four cases of PCNSL have previously been described in association with mycophenolate mofetil. We report the fifth case of PCNSL in a patient with lupus nephropathy while on mycophenolate mofetil treatment.Öğe The effect of lipoic acid in the prevention of myocardial infarction in diabetic rats(Comenius Univ, 2018) Ozgun, E.; Ozgun, Sayilan G.; Usta, U.; Eskiocak, S.; Sut, N.; Gokmen, Suer S.OBJECTIVES: We aimed to investigate the effect of lipoic acid in the prevention of myocardial infarction in diabetic rats. METHODS: Rats were divided into five groups as control, ISO, LA+ISO, STZ+ISO and STZ+LA+ISO. To induce diabetes, single dose of streptozotocin was injected to STZ+ISO and STZ+LA+ISO groups. Lipoic acid (10 mg/kg/day) was injected for 14 days to LA+ISO and STZ+LA+ISO groups. To induce myocardial infarction, isoproterenol was injected to ISO, LA+ISO, STZ+ISO and STZ+LA+ISO groups on the days 13 and 14 of lipoic acid treatment. Cardiac necrosis and leucocyte infiltration were investigated histopathologically. Serum malondialdehyde levels, paraoxonase and lactonase activities were measured spectrophotometrically. RESULTS: Isoproterenol caused a significant increase in cardiac necrosis, leucocyte infiltration and serum lipid peroxidation whereas a significant decrease in serum paraoxonase and lactonase activities. In myocardial infarcted non-diabetic rats, while lipoic acid caused a significant decrease in cardiac necrosis, leucocyte infiltration and serum lipid peroxidation and a significant increase in serum paraoxonase and lactonase activities, it did not change these histopathologic or biochemical parameters in myocardial infarcted diabetic rats. CONCLUSION: Lipoic acid, at the dose of 10 mg/kg, is effective to prevent myocardial infarction in non-diabetic rats but it is insufficient in diabetic rats.Öğe The effects of Enalapril and Irbesartan in experimental diabetic nephropathy(Diagnosis Press Ltd, 2007) Yalcin, O.; Ustundag, S.; Sen, S.; Usta, U.; Huseyinova, G.; Puyan, F. Oz; Kutlu, K.In our study we investigated the effects of angiotensin converting enzyme inhibitor and Angiotensin T, receptor blocker at low-doses which do not affect blood pressure and renal hemodynamia on the experimental diabetic nephropathy. Diabetes mellitus was induced by 50 mg/kg streptozotocin on Sprague-Dawley rats. Except for the patient control group, 2.5 mg/kg Enalapril (an angiotensin converting enzyme inhibitor) and 5 mg/kg Irbesartan (an Angiotensin T, receptor blocker) were given everyday via drinking water during six weeks period. After 24-hour urine collection, blood was withdrawn by cardiac puncture, and rats were sacrificed. Renal functions, histopathologic and electron microscopic alterations in renal tissues, and relative percent deposition of type IV Collagen were investigated. Diabetic nephropathy was determined with the increase of plasma glucose, HbA(9)C (P< 0. 000), urea, creatinin (P<0.005) and urinary protein, albumin, glucose (P<0. 000) inpatient control and Enalapril and Irbesartan treatment groups when compared to the healthy control group. Mesangiocellular proliferation, tubular basement membrane thickness, percentage of glomerular collagen accumulation reduced in treatment groups and glucose in urine in Enalapril group declined. Our findings suggest that renal protective effects of Enalapril and Irbesartan in the development of diabetic nephropathy were comparable.Öğe Idiopathic membranous nephropathy preceding membranous lupus nephritis: a case report(Sage Publications Ltd, 2020) Gokalp, C.; Aygun, G.; Dogan, A. F.; Usta, U.; Kurultak, I.; Ustundag, S.Membranous nephropathy is one of the most common causes of nephrotic syndrome in the adult population. According to the underlying etiology, membranous nephropathy is classified as either primary or secondary. Systemic lupus erythematosus is an autoimmune disease that can affect the kidneys in 50% of patients in the course of the disease. Renal disease may be the first manifestation of systemic lupus erythematosus and the development of systemic findings may be delayed for about 1-5 years following the diagnosis of lupus nephritis. We present a 59-year-old male patient who had a diagnosis of idiopathic membranous nephropathy since 2007 and developed membranous lupus nephritis during the 12-year follow-up without any extrarenal systemic lupus erythematosus findings.Öğe Ischemia-modified albumin and troponin I levels in isoproterenol-induced myocardial infarction in rats(Wiley, 2006) Kazezoglu, C.; Eskiocak, S.; Gokmen, S. Suer; Usta, U.; Cakir, E.[Abstract Not Available]Öğe Late-Onset Lung Metastasis in Rectum Cancer Can Be Confused with Primary Lung Cancer; a Case Report and Literature Review(Springer, 2019) Bozkaya, Y.; Albayrak, I.; Tucer, D.; Kaya, Z.; Usta, U.[Abstract Not Available]Öğe Mixt plexiform and desmoplastic ameloblastoma(Springer, 2021) Tastekin, E.; Usta, I.; Demirtas, E. Mercan; Usta, U.[Abstract Not Available]Öğe Mucoid Cyst of The Penile Skin: A Rare Entity(Pan African Urological Surgeons Assoc-Pausa, 2010) Yalta, T.; Kazindir, G.; Puyan, F. Oz; Tastekin, E.; Usta, U.; Ciftci, T.; Kutlu, A.A 9-year old male patient was admitted to our clinic for circumcision. Physical examination revealed a mass in the prepuce. After excision of the mass, histopathological examination was consistent with a mucoid cyst of the penile skin, which has been rarely reported. Pathologists and clinicians dealing with genitourinary system pathology should be familiar with this rarely encountered entity.Öğe Pleural localization of Castleman Disease: A rare entity(Springer, 2012) Tastekin, E.; Puyan, F. Oz; Isler, E.; Usta, U.[Abstract Not Available]Öğe THE PROTECTIVE EFFECT OF AMIFOSTINE ON RADIATION-INDUCED PROCTITIS: SYSTEMIC VERSUS TOPICAL APPLICATION(Elsevier Ireland Ltd, 2011) Uzal, M. C.; Sezer, A.; Usta, U.; Sut, N.; Ozen, A.; Yagci, M. A.[Abstract Not Available]Öğe Radiographic size versus surgical size of renal masses: Which is the true size of the tumor?(Imprimatur Publications, 2009) Alicioglu, B.; Kaplan, M.; Yurut-Caloglu, V.; Usta, U.; Levent, S.Purpose: The size of a renal neoplasm is important for staging, prognosis and selection of appropriate treatment. Our aim was to determine whether there is a discrepancy between the radiographic and pathological size of renal tumors. Patients and methods: The maximum size of 35 resected renal tumors was measured by computed tomography (CT) by 2 independent observers. The radiographic and pathological sizes were compared by size range and tumor radiological features. Results: Although the radiographic and pathological size for all tumors vas not statistically different (7.50 is. 6.25 cm, p=0.452), the average radiographic size was larger than pathological tumor size in tumors smaller than 7 cm. Solid tumors showed more reduction in size (17.02%) compared with cystic and necrotic tumors (p=0.731). Only the radiographic size of ill-defined tumors was smaller than their pathological size (average 33.33%; p=0.865). The influence of tumor side (left or right kidney) and its location within the kidney did not influence the degree of decrease (p=0.147 and p=0.981, respectively). Conclusion: A reduction in the size of renal tumors is observed in tumors < 7 cm, which is explained by, vasoconstriction during the temporary renal artery occlusion, sulfate hypothermia and blood loss during the operation. This reduction of size is secondary to surgery, the radiographic size of renal minors should be considered in staging and selecting the appropriate treatment for tumors < 7 cm for which the decision of surgical approach depends on the size of the tumor.Öğe Radioiodine-induced kidney damage and protective effect of amifostine: An experimental study(Lithographia, 2012) Aktoz, T.; Durmus-Altun, G.; Usta, U.; Torun, N.; Ergulen, A.; Atakan, I. H.Background: Ablative radioiodine-131 (I-131) therapy is used in the standart treatment procedure of thyroid carcinoma and procedures using I-131 represent the majority of Nuclear Medicine therapeutic procedures. The principal route of I-131 excretion after the administration of I-131 is the urine. Amifostine is an organic thiophosphate ester prodrug and the kidney concentrations of the active metabolite WR-1065 are about 100 times higher than tumour concentrations. To our knowledge, there is no published data in literature presenting acute effect of radioiodine on renal tissue during high dose I-131 radioiodine treatment (RIT). Additionally, it is not known whether amifostine takes role in this process. Materials and methods: In this study, 50 healthy female Wistar albino rats, weighing 200-250 g and averaging 16 weeks old were utilised. The rats were randomly divided into ten groups. 1-Sham group (n=5), 2-Amifostine group (n=5): rats pretreated with 1 cc amifostine (200 mg/kg) by intraperitoneal injection, 3- Radioactive iodine first day group (RI-1) (n=5): rats treated with 1 cc oral 185 MBq radioactive iodine-131 and sacrification performed after 1st day, 4- Amifostine + Radioactive iodine first day group (A+RI-1) (n=5): rats pretreated with amifostine (200 mg/kg) by intraperitoneal injection and rats treated with 5mCi radioactive iodine-131 and sacrification performed after 1st day. 5- Radioactive iodine third day group (RI-3) (n=5), 6- Amifostine + Radioactive iodine third day group (A+RI-3) (n=5), 7- Radioactive iodine fifth day group (RI-5) (n=5), 8- Amifostine + Radioactive iodine fifth day group (A+RI-5) (n=5), 9- Radioactive iodine seventh day group (RI-7) (n=5) and 10- Amifostine + Radioactive iodine seventh day group (A+RI-7) (n=5). The renal cast formation and tubular damage are evaluated by a pathologist in a blinded manner. Results: Ablative radioiodine-131 therapy induced renal tubular damage was significantly higher in the radioactive iodine fifth day group (RI-5) when compared with the Sham group (p=0.01) and Amifostine group (p=0.01). Conclusions: A marked ablative radioiodine-131 induced renal toxicity was seen at fifth day of the therapy after a single RIT application and the main histopathological change was tubular damage. Amifostine have protective effects against ablative radioiodine-131 therapy and this effect is significant at fifth day of the therapy. Hippokratia. 2012; 16 (1): 4045Öğe Risk factors for peritoneal dissemination of gastric cancer(Edizioni Minerva Medica, 2015) Yeldan, E.; Oguz, S.; Usta, U.; Ilhan, E.; Senlikci, A.Aim. Tumor dissemination, lymphnode involvement and surgical resection technique are the most important factors affecting patient prognosis with gastric cancer. Peritoneal dissemination adversely affects the survival rate in patients. Microscopic peritoneal dissemination can be detected with peritoneal lavage cytological examination. Peroperatively detected microscopic peritoneal dissemination changes the treatment plan for patients and can be useful when selecting patients who should undergo adjuvant chemotherapy. Methods. At the Trakya Universtity Faculty of Medicine, General Surgery Department, a 41-year-old patient who was macroscopic peritoneal dissemination during the dates January-December 2011 was included in the study. Perioperative peritoneal lavage was performed and cytological examination of peritoneal aspirate carried out. Using tumor markers the relationship between lymph node metastasis, prognostic type, tumor location and perineural invasion was investigated on the serum and peritoneal fluid. Results. Forty-one patients were operated on; 10 of them (24.4%) had positive malignant cytology and 31 (75.7%) had negative cytology. Just 1 (7.2%) patient was found to have positive cytology out of 13 (31.7%) that did not have serous invasion. Of the 28 (68.3%) patients with serous invasion, 9 patients (32.1%) were found to have positive cytology. No significant pattern was detected in the carcino-embryionic antigen, cancer antigen 19-9 and AFP levels in both the positive and negative cytology serum and peritoneal lavage fluid. Of found to have cardia dissemination and 13 (31.7%) were found to have dissemination located at the corpus. Peritoneal dissemination was found to be significantly high in gastric cancer located in the cardia and corpus. Fourteen (34.1%) of the patients had stage I and stage II cancer and 27 (65.9%) of patient's had cancer in stages III and IV. Just 1 (7.1%) patient with stage I or II cancer was found to have positive malignant cytology, however 9 (33.3%) patient's of stage III and IV gastric cancer patients were tested positively for malignant cytology. Conclusion. A positive relationship was detected in the positive peritoneal cell malignancy with cancer stage, age, invasion depth and tumor location in patients.Öğe Successful treatment of primary non-Hodgkin's lymphoma of the vulva with radiation therapy(Imprimatur Publications, 2009) Tokatli, F.; Oz-Puyan, F.; Alas, R.; Usta, U.; Yilmaz, H.; Uzal, C.Vulva, as a primary site of malignant lymphoma in women, is extremely rare. We report herein an 83-year-old patient with a primary, stage IIE vulvar, follicular center cell, B-cell lineage non-Hodgkin's lymphoma (NHL), with an excellent response to radiation therapy and event-free survival of 18 months. Early-stage primary vulvar NHL can be successfully treated only by limited fields irradiation.
