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Prevention of radiation-induced liver and kiney toxicity: a role for amifostine
(Kare Publ, 2007) Uguzalp-Kaldir, Mine; Yurut-Caloglu, Vuslat; Cosar-Alas, Rusen; Cermik, Tevfik Fikret; Altaner, Semsi; Eskiocak, Sevgi; Saynak, Mert
OBJECTIVES To investigate the protective effect of amifostine against radiation induced liver and kidney injury of rats, using scintigraphic and histopathologic parameters. METHODS Female Wistar Albino rats were randomly allocated to 3 groups: control, radiotherapy alone (RT), and amifostine+RT (n=10). Single-dose of 600 cGy X-ray was performed with a single field compromised liver and right kidney. Amifostine was administered intraperitoneally at a dose of 400 mg/kg, 30 minutes before irradiation. Scintigraphic evaluation was performed before irradiation and the end of the study at 6 nd month. Histopathologic examinations were performed post mortem. RESULTS A clear protective effect of amifostine against radiation-induced late dam age in liver and kidney was found with scintigraphic evaluaticn. In addition, amifostine reduced the decrease of histopathologic changes for both of the tissues. CONCLUSION The results showed that amifostine significantly reduced radiation-induced liver and kidney toxicity and therefore warrant additional study in a clinically relevant fractionated model.