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Öğe Comparison of the effectiveness of delirium evaluation tools in intensive care patients: pre-deliric versions 1 and 2, E-pre-deliric and ICDSC(Verduci Publisher, 2023) Kucuk, O.; Memis, D.; Inal, M. T.; Turan, F. N.; Memis, I.OBJECTIVE: This study's objective was to compare the effectiveness of the delirium prediction model (predeliric) and the early prediction model (E-predeliric) in delirium prediction in an intensive care unit (ICU) according to the Intensive Care Delirium Screening Checklist (ICD-SC). Our aim was to determine these models' us-ability and cut-off values for ICU patients. PATIENTS AND METHODS: We classified the studied patients based on their highest ICDSC scores (tested twice daily) during ICU hospitaliza-tion. ICDSC scores of 4 or higher indicated positive results for delirium, whereas a score of 0 represented a negative result. We recorded the patients' demographic and clinical details and characteristics and calculated their E-predeliric and predeliric version 1 and version 2 scores. To evaluate the effectiveness of the models, we used receiver operating characteristic (ROC) curve analysis. RESULTS: Two hundred fifty patients (55.6% males, mean age 60.6 +/- 18.7 years) participated in this study. Their mean Acute Physiology and Chronic Health Evaluation II (APACHE-II) score was 17.0 +/- 9.1. Delirium was more common in men, patients of older ages, those with high APACHE-II scores, those who had undergone urgent admissions, those with histories of trauma, those with high urea or creatinine values and those who had undergone sedation or mechanical ventilation. Compared to patients who did not develop delirium, those who did had longer ICU stays and hospital stays, as well as greater mortality risk. The cutoff values for the patients' pre-deliric version 1, predeliric version 2 and E-pre-deliric scores were 38% [area under ROC (AUROC)=1], 22% (AUROC=1) and 28% (AUROC=1), respectively. CONCLUSIONS: This study is the first to compare the pre-deliric and E-pre-deliric prediction models. These models' validity and reliability were acceptable. They were clinically use-ful, and we identified their cut-off values. These models provide options for early detection of delirium and are easily applicable in the ICU.Öğe An investigation of the relationship between the eNOS gene polymorphism and diagnosed migraine(Wiley, 2016) Guler, S.; Gurkan, H.; Tozkir, H.; Turan, F. N.; Celik, Y.[Abstract Not Available]Öğe Prognosis and risk factors of nerve injuries in displaced pediatric supracondylar humerus fractures(Wolters Kluwer Medknow Publications, 2020) Ozcan, M.; Altinoz, O.; Erem, M.; Ciftdemir, M.; Copuroglu, C.; Turan, F. N.Background: Supracondylar humerus (SCH) fractures are serious injuries due to the neighborhood of critical neural and vascular structures. One of the most devastating complications of SCH fractures is neurological damage, since it may cause permanent disability. The aim of this study is to categorize neurological complications, to report long-term functional outcomes, and to determine risk factors associated with childhood SCH fractures. Methods: The records of 375 children were reviewed retrospectively. Data about amount and direction of displacement, the shape of the fracture, age at the time of fracture, gender, time from impaction to surgery, time of surgery, type of neurological injury, and recovery time were recorded. Results: Neurological complications were seen in 37 (9.85%) children. Thirteen (35.1%) of the children had an iatrogenic nerve injury. All iatrogenic injuries were fully recovered in this study. However, 2 children who had combined neurological injury of radial, ulnar, and median nerves did not recover. Nearly 95% of all children who had neurological injury recovered fully. An anterior long and sharp bone fragment (spike) was observed in most of the children with neurological injury, and this spike was seen in 14 (58.3%) patients who had a trauma-related injury (n = 24). Conclusion: The prognosis of these nerve injuries is excellent, especially the iatrogenic ones. A long and sharp bone fragment (spike) may be responsible for nerve injuries in some children. Surgical exploration is not necessary after an iatrogenic nerve injury when there is no neurotmesis. Patience and care are utmost needed to handle neurological complications.Öğe Prognostic factors other than the performance status and age for glioblastoma multiforme: a single-institution experience(Imprimatur Publications, 2009) Caloglu, M.; Yurut-Caloglu, V.; Karagol, H.; Bayir-Angin, G.; Turan, F. N.; Uzal, C.Purpose: To evaluate the survival of patients with glioblastoma multiforme (GBM) and analyse the prognostic Actors influencing survival. Patients and methods: Seventy-eight consecutive patients with GBM treated with radiotherapy (RT) and temozolomide (TMZ) (in 21 patients) between 1999 and 2006 were retrospectively analysed. Results: Sixty-seven (85.5%) patients had undergone gross total or subtotal resection before RT The median overall survival was 9.8 months, and significantly influenced by age (p=0.02), Karnofsky performance status (p=0.001), RT (p<0.0001), gender (p=0.02), concomitant TMZ (p=0.003), RT waiting time (p=0.014), and treatment time (p=0.01) in univariate analysis. In multivariate analysis, older age (p=0.03), male gender (p=0.01), absence of concomitant TMZ (p=0.008), RT dose below 60 Gy (p=0.03), RT waiting time more than 20 days (p=0.01), and treatment time more than 76 days (p=0.0072) were poor prognosticators. Conclusion: This study emphasizes the importance of female gender, dose and duration of RT and RT waiting time in patients with glioblastoma multiforme.Öğe The protective effect of L-carnitine on ionizing radiation-induced free oxygen radicals(Scandinavian Soc Laboratory Animal Science, 2006) Dokmeci, D.; Akpolat, M.; Aydogdu, N.; Uzal, C.; Doganay, L.; Turan, F. N.Ionizing radiation is known to generate reactive oxygen species (ROS) that can be removed by antioxidants. L-carnitine, a natural component of mammalian tissue, is a necessary factor in the utilization of long-chain fatty acids to produce energy. Furthermore it has been shown that L-carnitine is an antioxidant which has a scavenger effect on ROS and a stabilizing effect on damaged cell membranes. The aim of the study was to evaluate the potential protective effect of L-carnitine on radiation-induced free radicals in hamsters. L-carnitine was given by gavage at a dose of 50 mg/kg for 15 consecutive days before irradiation with a single dose of 8 Gy. 24 h after radiation exposure, the hamsters were sacrificed and samples were taken from blood and tissues, and the biochemical and histopatological determinations were carried out. In the irradiated group, there were significant increases in plasma and liver malondialdehyde (MDA) with marked reduction in glutathione (GSH) levels in the liver, compared with controls. In red blood cells, superoxide dismutase (SOD) and catalase activities were also reduced. All these effects were reversed by L-carnitine. In conclusion, L-carnitine with its antioxidant and free radical scavenging properties could play a modulatory role against the cellular damage produced by free radicals induced by ionizing radiation.Öğe Turkish version quality of life in essential tremor questionnaire (QUEST): a validity and reliability study(Wiley, 2016) Guler, S.; Turan, F. N.[Abstract Not Available]
