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    The Effects of Experimental Intratympanic Steroid Administration on Organ of Corti Type 1 Spiral Ganglion
    (Georg Thieme Verlag Kg, 2018) Topcuoglu, Turgay; Kocyigit, Murat; Bulut, Erdogan; Ortekin, Safiye G.; Kanter, Mehmet; Yagiz, Recep
    Introduction It is unclear how effective is the intratympanic (IT) steroid treatment on organ of Corti type 1 spiral ganglion, its optimal dosage and frequency of administration. The effect of dexamethasone on cochlear functions in individuals with a normal hearing ability is also unknown. Objective The aim of this study was to evaluate, at the electrophysiological and ultrastructural levels, the effect of IT dexamethasone administration in guinea pigs with normal hearing on organ of Corti type 1 spiral ganglion. Methods A total of 20 guinea pigs ( n =40 ears) whose hearing was detected to be normal by electrophysiological tests were included in the study and randomly divided into 6 groups. Four groups were considered study groups, while 2 groups were considered control groups. Dexamethasone was administered intratympanically in doses of 2 mg/mL and 4 mg/mL in the guinea pigs in the study groups. The animals in the control groups received physiological saline in equal doses as the study groups. All interventions were performed under general anesthesia, and the electrophysiological tests were repeated following the IT injections. Results No statistically significant differences were found among the groups when the IT injections were evaluated in terms of the electrophysiological measurements ( p >0.05). The ultrastructural evaluation showed a cellular mitochondrial increase in the spiral ganglions of the cochlea in the groups in which dexamethasone was administered in a dose of 4 mg/mL. Conclusion According to the findings of this study, it can be suggested that the IT injection of dexamethasone is safe, and when applied in a dose of 4 mg/mL, it increases metabolic activity at the cellular level.
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    The results of tracheotomy in patients with prolonged intubation
    (Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2008) Tas, Abdullah; Yagiz, Recep; Topcuoglu, Turgay; Kocyigit, Murat; Uzun, Cem; Karasalihoglu, Ahmet Rifat
    Objectives: We evaluated early and late complications of tracheotomy in patients who underwent tracheotomy for prolonged entubation. Patients and Methods: This retrospective study included 227 patients (124 males, 103 females; mean age 47.2 years; range 3 to 85 years) who underwent tracheotomy for prolonged entubation during hospitalization at Reanimation and Intensive Care Unit, Coronary Intensive Care Unit, Cardiovascular Surgery Intensive Care Unit, Neurology Unit, and Chest Diseases Unit. There were 10 children and 217 adult patients. Patients who underwent tracheotomy for upper airway obstruction were excluded. Results: The mean duration of intubation was 10.4 days (range 9 to 13 days). Early complications included hemorrhage (n=15, 6.6%) and subcutaneous emphysema (n=3, 1.3%), and late complications included laryngotracheal stenosis (n=2, 3.2%) and difficult decannulation (n=1, 1.6%). Mortality due to tracheotomy did not occur. Conclusion: Establishing a tracheotomy in patients with prolonged intubation is a reliable surgical procedure with low complication risk, providing a safe ventilatory respiration.