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    Evaluation of significant radiographic findings and their impact on the oral health-related quality of life of patients with complete dentures
    (Quintessence Publishing Co Inc, 2018) Cabbar, Fatih; Burdurlu, Muammer Cagri; Capar, Gonca Duygu; Tekin, Hakkican; Tomruk, Ceyda Ozcakir
    Purpose: The aim of this study was to assess the frequency and location of positive radiographic findings in edentulous patients and to evaluate the oral health-related quality of life (OHRQoL) and complacency of patients with positive radiologic findings. Materials and Methods: A total of 1,349 asymptomatic edentulous patients were retrospectively evaluated using a digital panoramic system for the presence of retained root fragments, impacted teeth, foreign bodies, radiolucencies, radiopacities, mental foramen at or near the alveolar crest, and maxillary sinus pneumatization. The patients with positive findings were called for a follow-up to take a new panoramic radiograph. The functional status and symptoms of participants were measured with the Oral Health Impact Profile (OHIP-14). Results: At least one or more of the radiographic findings were observed in 35.21% of the evaluated radiographs. The most frequent finding was sinus pneumatization (20.9%). The mean total OHIP score was 9.74 +/- 8.34. There was no statistically significant difference observed for gender, age, education levels, marital status, or having surgical interventions for total OHIP14 scores (P > .05). Conclusion: The results of this study suggest that routine radiographic examination of edentulous patients may not be crucial before rehabilitation, and using a total percentage of positive radiographic findings may result in the exaggeration of the disease risk in edentulous patients.
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    Histopathological evaluation of the effect of systemic thymoquinone administration on healing of bone defects in rat tibia
    (Taylor & Francis Ltd, 2017) Arslan, Ahmet Hamdi; Tomruk, Ceyda Ozcakir; Meydanli, Elif Guzel; Ozdemir, Ilkay; Capar, Gonca Duygu; Kutan, Esma; Yilmaz, Ayse
    The aim of the present study was to assess the systemic effect of thymoquinone (TQ) on bone healing by starting TQ administration, either 40 days before, or on the day of the surgical procedure and continuing during the healing period of 28 days. Eighteen experimental rats were divided into three groups and defects were created in their tibias. The following procedures were performed for each group: Control group (C): No systemic drug administration (n D 6); Test group 1 (T1): Systemic TQ was administered daily starting 40 days before creation of the defect and additionally during the post-operative healing period of 28 days (n = 6); Test group 2 (T2): Systemic TQ was administered daily after creation of the defect and during the healing period of 28 days (n = 6). Quantitative measurement for new bone formation, osteoblast lining and semi-quantitative measurement of capillary intensities were examined and statistically analysed. There was a significant increase in the ratio of new bone per total defect area and new bone trabeculae lined by active osteoblasts in both test groups (T1 and T2) compared to control group (p < 0.05). However the difference between T1 and T2 was not statistically significant. TQ-administered groups also showed an increase in capillary intensity in the defect area compared to the control group (p < 0.05). Systemic administration of TQ either starting 40 days before or on the day of surgery accelerated new bone formation in a rat model and can be advocated as an adjunct to expedite bone healing.
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    Prevalence of sinus floor elevation procedures and survival rates of implants placed in the posterior maxilla
    (Taylor & Francis Ltd, 2016) Tomruk, Ceyda Ozcakir; Sencift, Mehmet Kemal; Capar, Gonca Duygu
    The aim of this study was to assess the prevalence of sinus-lifting procedures and survival rates of implants placed in the posterior maxilla. This retrospective chart review examined consecutive patients with tooth/teeth loss in the posterior maxilla between 2008 and 2012 treated with sinus lift, when needed, and implant insertion. Demographic variables, health status, residual alveolar bone height, augmentation types, the implant position, diameter and height, and implant failure, prosthesis types, and the marginal bone loss were recorded. The study included 302 patients at a mean age of 5.2years, who received a total of 609 dental implants. A total of 380 (62.3%) implants were inserted in native areas, 203 (33.3%) ones in external sinus-lifted areas and 26 (4.4%) ones in internal lifted areas. The survival rate in native or internal lifted areas were 100% and 95.6% in external sinus lifted ones (10 implant failures/203 implants). Almost half of the implants were examined radiologically with a mean duration of 30 months and the mean marginal bone loss was 0.64 +/- 1.2 mm. The results showed that the survival rates of native bone and the internal sinus lifting were slightly higher than that of external sinus lifting. Implants placed with sinus augmentation exhibited more marginal bone loss than implants in native bone.
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    Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study
    (Taylor & Francis Ltd, 2016) Capar, Gonca Duygu; Sapmaz-Metin, Melike; Kutan, Esma; Tomruk, Ceyda Ozcakir; Yalcin, Gul Merve; Er, Nilay; Ozfidan, Gulnur Kizilay
    The aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.