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    Brain metastases occurrence among metastatic breast cancer: A single oncology center experience.
    (Amer Soc Clinical Oncology, 2005) Uygun, K; Karagol, H; Tokatli, F; Caloglu, M; Donmez, S; Tas, F
    [Abstract Not Available]
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    Pituitary metastasis mimicking a macroadenoma from carcinoma of the larynx: A case report
    (Pensiero Scientifico Editor, 2001) Uzal, MC; Kocak, Z; Doganay, L; Tokatli, F; Caloglu, M; Kilincer, C
    Metastatic tumors of the pituitary gland are not commonly diagnosed during life in cancer patients. The occurrence of symptomatic lesions is also very unusual and difficult to differentiate clinically and radiologically from pituitary adenomas. Furthermore, a single intrasellar metastasis from laryngeal carcinoma mimicking a pituitary adenoma is an extremely rare pathological finding. We report on the clinical, radiological, and pathological findings in a patient with laryngeal carcinoma who had a symptomatic solitary pituitary gland metastasis that was recognized antemortem.
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    The potential cardioprotective effects of amifostine in irradiated rats
    (Elsevier Science Inc, 2004) Tokatli, F; Uzal, C; Doganay, L; Kocak, Z; Kaya, M; Ture, M; Kurum, T
    Purpose: The aim of this study is to determine the cardioprotective efficacy of amifostine. The study consists of researching the relationship between plasma brain natriuretic peptide levels and the electrical and morphologic changes in irradiated rats with or without amifostine. Methods and Materials: Sixty Wistar albino rats were divided into 4 groups, and their hearts were given 15 Gy/fraction with Co-60. In Groups I and II, the rats were killed after 24 hours to detect early effects; in Groups III and IV, the rats were killed 100 days after irradiation to detect late effects. Before irradiation, Groups I and III received 0.9% saline solution, whereas Groups II and IV received amifostine (200 mg/kg). Twenty rats were used as a control group. Results: On the 100th day, mild myocardial degeneration was detected in 5 rats (33%) from Group III (no amifostine). This percentage was statistically different from that of Group IV (treated with amifostine) and the controls (p = 0.042). There was no statistically significant difference between the mean plasma brain natriuretic peptide values of the groups (p > 0.05). There was no significant difference in electrocardiographies between the groups. There was no correlation between continuous variables. Conclusion: In the amifostine group (IV) on the 100th day, there was no myocardial degeneration, suggesting that amifostine has a cardioprotective effect. (C) 2004 Elsevier Inc.
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    Sequential pulmonary effects of radiotherapy detected by functional and radiological end points in women with breast cancer
    (Elsevier Science London, 2005) Tokatli, F; Kaya, M; Kocak, Z; Ture, M; Mert, S; Unlu, E; Alkaya, F
    Aims: To determine the pulmonary effects of locoregional irradiation on clinical and sub-clinical radiographic and functional end points in women with breast cancer, and whether the course of these end points is affected by laterality. Materials and methods: Twenty patients (10 irradiated on the left side and 10 irradiated on the right side) were prospectively evaluated for changes in pulmonary function tests, Tc-99m DTPA (diethylenetriamine pentaacetic acid) lung clearance scintigraphy and high-resolution computed tomography (HRCT) at 6, 16 and 52 weeks after radiotherapy. Tc-99m DTPA clearance, expressed as the biological half-time, T (1/2), was computed from the time-activity curves for 10 min for each lung. The irradiated lung volume was calculated for each patient. Results: The mean irradiated lung volume was 6.4% +/- 2 (range 3-11 %) for the entire population. In the whole study population, two (10%) patients, who were irradiated on the left side, had mild symptomatic radiation pneumonitis in the follow-up period. There was a statistically significant gradual reduction in all pulmonary function test values during the follow-up period. For patients irradiated on the left side, Tc-99m DTPA clearance T-1/2 values were statistically significantly decreased during the follow-up period (P = 0.03), but the decrease was not statistically significant for patients irradiated on the right side (P = 0.62). Tc-99m DTPA clearance T-1/2 values were statistically significantly decreased in the irradiated lung compared with the opposite lung, and no improvement was seen at week 52 after radiotherapy. The number of patients with changes on HRCT scans increased after radiotherapy, reaching a maximum at 16 weeks, when 80% of patients had changes. There was subsequent partial recovery 52 weeks after radiotherapy. Conclusion: Locoregional irradiation for breast cancer may cause sub-clinical irreversible impairment of radiological and functional pulmonary parameters. The increase in clearance rate of Tc-99m DTPA may be more prominent for patients with left-sided breast cancer. Tokatli, F. et al. (2005). (C) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.