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Öğe Acute Effects of Intermittent Exercise Performed at Anaerobic Threshold Level on Vascular Function in Healthy Young Men(Wiley, 2019) Sen, Burcu; Solak, Serdar; Tayfur, Pinar; Aydogdu, Nurettin; Sut, Necdet; Vardar, Selma Arzu[Abstract Not Available]Öğe Alteration in cardiac PI3K/Akt/mTOR and ERK signaling pathways with the use of growth hormone and swimming, and the roles of miR21 and miR133(Spandidos Publ Ltd, 2019) Palabiyik, Orkide; Tastekln, Ebru; Doganlar, Zeynep Banu; Tayfur, Pinar; Dogan, Ayten; Vardar, Selma ArzuAthletes misuse recombinant human growth hormone (r-hGH) to enhance their performance. Although r-hGH is known to increase cardiac hypertrophy, the underlying molecular mechanism remains unclear. The aim of the present study was to investigate the role of r-hGH in cardiac intracellular signaling pathways and of miR-21 and miR-133 expression in rat hearts during exercise. A total of 36 adult male Sprague-Dawley rats were divided into sedentary control (SC, n=9), swimming exercise (SE, n=8), r-hGH (GH, n=10) and swimming exercise plus r-hGH (SE-GH, n=9) groups. The exercise groups completed a 1-h swimming exercise 5 times a week for 8 weeks. Subcutaneous r-hGH was administered as 0.3 mg/kg/day. Phosphoinositide-3-kinase (PI3K), serine/threonine protein kinase 1 (AKT1), extracellular signal-regulated kinase (ERK), microRNA (miR)-21 and miR-133 expression was evaluated in ventricular muscle by real-time quantitative polymerase chain reaction. Protein expression of PI3K, AKT1, ERK and mechanistic target of rapamycin (mTOR) was also assessed by immunohistochemistry. Statistical differences were analyzed by two-way ANOVA. PI3K and AKT1 expression and the gene and protein levels was notably increased in the SE-GH group compared with in SC ventricular tissues (P<0.05). mTOR protein expression was higher in the GH, SE and SE-GH groups compared with in the SC group (P<0.05, <0.05 and <0.001, respectively). ERK gene/protein expression was similar across all groups. miR-21 and miR-133 levels in ventricular muscle were higher in the SE and GH groups than those in the SC group. In summary, growth hormone application coupled with swimming exercise appeared to affect the PI3K/AKT/mTOR signaling pathway in the left ventricular tissue of rats; however, ERK signaling pathway appeared inactive in physiological left ventricular hypertrophy caused by swimming and GH administration over 8 weeks. Furthermore, GH treatment resulted in increased miR-21 and miR-133 expression. Future study by our group will aim to assess the effects of higher dose GH treatment.Öğe The Comparison of the Perceived Exertion of Physically Active and Non-Active Men During High Intensity Cycling Intervals(Wiley, 2018) Vardar, Selma A.; Doganlar, Zeynep B.; Kaya, Oktay; Tayfur, Pinar; Sut, Necdet; Merakli, Meryem A.; Doganlar, Oguzhan[Abstract Not Available]Öğe The effect of fructose rich diet and voluntary physical activity on cardiac hemodynamic responses during ischemia and reperfusion of isolated rat heart(Wiley-Blackwell, 2016) Vardar, Selma Arzu; Tayfur, Pinar; Palabiyik, Orkide; Tastekin, Ebru; Uzun, Nursen; Sut, Necdet[Abstract Not Available]Öğe The effect of growth hormone and/or swimming exercise on PI3K, AKT, PTEN and miR21 expressions in rats(Wiley-Blackwell, 2016) Palabiyik, Orkide; Tastekin, Ebru; Doganlar, Zeynep Banu; Tayfur, Pinar; Vardar, Selma Arzu[Abstract Not Available]Öğe Effect of Voluntary Exercise on Water Intake and Blood Pressure in Male Rats(Wiley, 2019) Tayfur, Pinar; Sen, Burcu; Vardar, Selma Arzu[Abstract Not Available]Öğe The Effects of Irisin on Experimental Hypertension in Rats(Wiley, 2017) Aydogdu, Nurettin; Tastekin, Ebru; Tayfur, Pinar; Yavuz, Ozlem Yalcinkaya; Kaya, Oktay; Kandemir, Nihayet[Abstract Not Available]Öğe Effects of Physical Activity on Metabolic and Cardiac Hemodynamic Alterations Related with Fructose-rich Diet(Wiley-Blackwell, 2016) Tayfur, Pinar; Palabiyik, Orkide; Uzun, Nursen; Sut, Necdet; Vardar, Selma Arzu[Abstract Not Available]Öğe Evaluation of the Effects of High Intensity Interval Training on Cytokine Levels and Clinical Course in Treatment of Opioid Use Disorder(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2020) Durmus, Pelin Tas; Vardar, Mehmet Erdal; Kaya, Oktay; Tayfur, Pinar; Sut, Necdet; Vardar, Selma ArzuObjective: Opioid use disorder (OpUD) is a biological and psychosocial disorder with limited treatment options. Addition of physical exercise to the pharmacological treatment has been proposed to be effective on reducing substance use and improving the quality of life. In this study we aimed to investigate the effects of a high-intensity interval training (HIIT) program on the serum levels of cortisol, insulin-like growth factor1 (IGF-1), interferon-gamma (IFN-gamma), interleukin 17 (IL-17) and the clinical progress of inpatients with OpUD. Method: Our study enrolled 22 male inpatients diagnosed with OpUD on the basis of the DSM-5 criteria. Two groups of 11 individuals were formed as the exercise (EG) and the control (CG) groups. The EG conducted 5 sessions of a HIIT. Participant data were collected with Sociodemographic Questionnaire, the Addiction Profile Index (API), and the Barratt Impulsiveness Scale (BIS-11). Also, the Hamilton Depression Rating Scale (HAM-D), the Hamilton Anxiety Rating Scale (HAM-A) and the Substance Craving Scale (SCS) were used before and after the treatment program in order to evaluate the clinical progress. Blood samples were collected on the 5th and the 21st days for estimation of the serum cortisol, IGF-1, IFN-gamma and the IL-17 levels. Results: Comparison of the pre- and the post-treatment performances of the two groups on the HAM-D, the HAM-A and the SCS indicated a significant drop in the respective scores of the EG. Also, a significant increase was observed in the post-treatment IGF-1 level of the EG as compared to the CG. No differences were observed between the cortisol, IFN-gamma and IL-17 levels of the EG and the CG. Conclusion: HIIT resulted in significant reduction in the symptoms of depression, anxiety and substance craving, and increased the serum IGF-1 levels. HIIT did not change serum cortisol, IFN-gamma and IL-17 levels. We believe this research will contribute to the literature on the treatment of opioid depencence by emphasising the effects of HIIT on patients treated for OpUD.Öğe Growth Hormone Affects PI3K/AKT/mTOR Signaling Pathways in the Rat Heart Subjected to Exercise(Wiley-Blackwell, 2016) Palabiyik, Orkide; Tayfur, Pinar; Tastekin, Ebru; Doganlar, Zeynep Banu; Vardar, Selma Arzu[Abstract Not Available]Öğe Metabolic and inflamatuar effects of voluntary physical activity in male rats fed with fructose rich diet(Wiley-Blackwell, 2016) Tayfur, Pinar; Palabiyik, Orkide; Uzun, Nursen; Sut, Necdet; Vardar, Selma Arzu[Abstract Not Available]Öğe Voluntary Physical Activity Produces cGMP Mediated Lipolytic Effect in Retroperitoneal Adipose Tissue of Fructose-Rich Fed Rats(Wiley, 2022) Tayfur, Pinar; Palabiyik, Orkide; Sen, Burcu; Tastekin, Ebru; Vardar, Selma Arzu[Abstract Not Available]
