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Öğe Clinical features of congenital neck masses in children(Aves Yayincilik, Ibrahim Kara, 2007) Inan, Mustafa; Yagiz, Recep; Tas, Abdullah; Ayvaz, Sueleyman; Ada, ServetObjectives: Diagnostic approaches and treatment methods in children with a congenital neck mass were evaluated. Patients and Methods: A total of 36 patients (20 girls, 16 males; mean age 8.6 +/- 5.9; range 1 month to 15 years) treated in our hospital for congenital neck mass between 1996 and 2003, were retrospectively analysed. Results: Thirteen cases were diagnosed as dermoid cyst, 7 as branchial cyst, 7 as thyroglossal duct cyst (TDC), 5 as torticollis, 4 as cystic hygroma and 1 as lipoblastorna. In all 7 of the cases with TDC, the mass presented with a cutaneus fistula. Two of the branchial cysts were localized on the right and the rest on the left side. One of the cases with dermoid cyst exhibited a lateral localization. Ultrasonography, computed tomography and thyroid syntigraphy were used for diagnostic purposes. Three patients with torticollis received physical therapy while the remaining patients were surgically treated. The preliminary diagnosis was incorrect in four cases and their histopathological diagnosis was dermoid cyst. Conclusion: Congenital neck masses in children are usually benign. Due to their similar clinical features, dermoid cysts can be confused with TDC and branchial cysts.Öğe The Clinical Significance of Incidental Parotid Uptake in a PET/CT Study: A Diagnostic Algorithm(Bentham Science Publ Ltd, 2019) Ustun, Funda; Tastekin, Ebru; Tas, Abdullah; Altun, Gulay DurmusBackground: Patients diagnosed with cancer do not have sufficient clinical data for the management of incidental parotid lesions. We aimed to reveal the importance of randomized parotid lesions encountered during oncologic F-18 fluorodeoxyglucose positron emission tomography (FDG PET/CT) imaging in our clinical practice and the diagnostic algorithm of such lesions. Methods: We performed a database search of PET/CT records generated from 2009 to 2015 for parotid in reports of patients who underwent PET/CT examination for a known malignancy elsewhere, or cancer screening. Results: Incidental parotid FDG uptake on PET/CT had a prevalence of 1.1%. The incidence of parotid metastasis in our series was 36.4%, and 75% of them had malign melanoma metastasis. Of the 11 cases, 5 were of Warthin tumours, and Warthin tumours showed stronger GLUT1 expression than metastatic parotid lesions. Conclusion: In patients with malignancy elsewhere, focal involvement of FDG by the parotid gland, especially if malignant melanoma or SCC is absent, should not be considered a metastatic disease without histopathologic confirmation. If parotid disease would change the patient's treatment plan and disease stage, the parotid lesion should be evaluated by additional methods, such as fine needle aspiration biopsy.Öğe Dermoid cyst of the parotid gland: First pediatric case(Elsevier Ireland Ltd, 2010) Tas, Abdullah; Yagiz, Recep; Altaner, Semsi; Karasalihoglu, Ahmet R.A dermoid cyst is the result of inclusion of epithelial cells along the lines of embryonic closure. Dermoid cysts of the head neck are uncommon and account for only 7% of all such cysts. They are most often reported as arising in the floor of the mouth. Dermoid cyst is rarely seen in the parotid gland. To our knowledge, there have been only six previous case reports in the English literature. Dermoid cyst of the parotid gland in pediatric patient has not been previously reported in the literature. This is the first case report concerning a dermoid cyst in a pediatric patient. (C) 2009 Elsevier Ireland Ltd. All rights reserved.Öğe Effect of Topical Dexamethasone for Preventing Experimentally Induced Myringosclerosis(Galenos Yayincilik, 2017) Uestuendag, Murat; Kocyigit, Murat; Bulut, Erdogan; Altaner, Semsi; Tas, Abdullah; Yagiz, RecepObjective: We aimed to examine the effect of topical dexamethasone by otomicroscopic and histologic examinations for preventing myringosclerosis induced by myringotomy in rat tympanic membranes. Methods: Twenty-one Sprague Dawley rats (42 ears) were randomly divided into the following three groups after otomicroscopic examinations: experimental surgical group (5 rats), control group (8 rats), and study group (8 rats). The rats of all the groups underwent myringotomy in both tympanic membranes. Other than myringotomy, no additional procedure was performed for the rats in the experimental surgical group. In the control group, 0.9% NaCl was applied to the ears, whereas in the study groups, topical dexamethasone was applied to the ears. These applications in the control and study groups were repeated for nine days. On the 10th day of the study, the rat ears of all groups underwent otomicroscopic and histologic examinations. The prevalence and process of myringosclerosis were evaluated by otomicroscopic examination, whereas inflammation, membrane thickness, and myringosclerosis intensity were evaluated by histologic examination. Results: The growth of myringosclerosis with otomicroscopic examination was lesser in the study group in which topical dexamethasone was applied than the control and experimental surgical groups. Moreover, it was observed that myringosclerosis effected less quadrants in the study group. Histologic examinations revealed that inflammation was significantly lesser in the study group than in the experimental surgical and control groups. The average membrane thickness values were significantly lesser in the study group than in the experimental surgical group. With respect to myringosclerosis growth, no statistically significant difference was observed among all groups, whereas with respect to myringosclerosis intensity, the rat ears in the study group were less severely affected. Conclusion: Thus, our study results suggest that applying topical dexamethasone after myringotomy has positive effects on limiting the intensity and prevalence of myringosclerosis.Öğe Effects of Intratympanic Steroid on Cisplatin Ototoxicity: An Electrophysiological and Ultrastructural Study(Akad Doktorlar Yayinevi, 2018) Tas, Abdullah; Bulut, Erdogan; Tas, Memduha; Yagiz, Recep; Turan, Pinar; Huseyinoglu, Aydin; Karasalihoglu, Ahmet R.Ototoxicity refers to the inner ear dysfunction caused by a drug or a chemical agent which manifests as hearing loss or balance impairment, or both. Currently, antibiotics, diuretics, anti-inflammatory drugs, antineoplastic agents, antimalarial drugs and some other agents are known to cause ototoxicity. Cisplatin is an antineoplastic agent for which the ototoxicity incidence may vary based on the treatment protocol. In the present study, we aimed to perform an electrophysiological and ultrastructural evaluation regarding the protective effectiveness of intratympanic steroids on cisplatin ototoxicity. Electrophysiological assessment included tympanometry and auditory brainstem response (ABR), and 16 guinea pigs (32 ears) with normal hearing were randomly assigned to 4 groups as follows: control, cisplatin, cisplatin/steroid and cisplatin/physiological saline. Following the electrophysiological measurements, temporal bones were dissected for ultrastructural examinations. In the cisplatin group, a statistically significant (p<0.05) threshold difference was noted for the ABR test versus the other groups while this threshold difference was lower in the cisplatin/steroid group compared to the other groups. Ultrastructural evaluations revealed abnormal outer hair cell stereocilia morphology and severe degenerative changes in the cisplatin and cisplatin/physiological saline groups. Mild degenerative alterations were seen in the outer hair cell stereocilia morphology in the guinea pig cochlea administered with intratympanic steroid. We believe intratympanic steroid administration showed protective effectiveness on the cisplatin-induced ototoxic damage in our study.Öğe Evaluation of hearing in children with autism by using TEOAE and ABR(Sage Publications Ltd, 2007) Tas, Abdullah; Yagiz, Recep; Tas, Memduha; Esme, Meral; Uzun, Cem; Karasalihoglu, Ahmet RifatAssessment of auditory abilities is important in the diagnosis and treatment of children with autism. The aim was to evaluate hearing objectively by using transient evoked otoacoustic emission (TEOAE) and auditory brainstem response (ABR). Tests were performed on 3 0 children with autism and 15 typically developing children, following otomicroscopy and tympanometry. The children with autism were sedated before the tests. Positive emissions and normal hearing level at ABR were obtained in both ears of all children in the control group and of 25 children with autism. TEOAE and ABR results varied in the remaining five children with autism. The mean III-V interpeak latencies (IPLs) in both ears of children with autism were longer than those in the control group. Hearing loss may be more common in children with autism than in typically developing children.Öğe Evaluation of Surgical and Histopathologic Results of Patients Operated for Parotid Gland Tumor(Aves Yayincilik, Ibrahim Kara, 2009) Tas, Abdullah; Giran, Safiye; Yagiz, Recep; Yalcin, Oemer; Koten, Muhsin; Adali, Mustafa Kemal; Karasalihoglu, AhmetObjectives: To investigate the patients with parotid tumors retrospectively and to evaluate the surgical procedure, histopathologic results, incidence, follow-up time and complications. Patients and Methods: The study included 56 patients (38 males, 18 females; mean age 52.7 years; range 7 to 86 years) who presented with a mass below or in front of the ear between January 2000 and May 2008. The data regarding patient age, sex, surgical procedure, postoperative histopathologic results and follow-up time were recorded. Results: One of the male patients underwent operation twice because of the bilateral parotid mass. According to the postoperative histopathologic results, 37 of the cases were benign (64.9%), and 20 of them were malign (35.1%). Pleomorphic adenoma (13 patients) and Whartin tumor (13 patients) incidence were similar. Partial superficial parotidectomy, superficial parotidectomy, and total parotidectomy were performed. In addition, some of the patients underwent neck dissection. The most frequent complication was transient facial nerve paresis. Conclusion: For the management of benign parotid gland tumors, superficial or partial superficial parotidectomy is a sufficient surgery. For malign tumors, superficial or total parotidectomy; in cases with neck masses, neck dissection; and in cases involving the facial nerve, facial nerve resection and reconstruction should be performed. According to the type of tumor, postoperative radiation therapy and chemotherapy should be performed as well.Öğe Frequency of Epstein-Barr virus and human papilloma virus in patients with nasopharyngeal carcinoma(Springer, 2020) Altekin, Ilhan; Tas, Abdullah; Yalcin, Omer; Guven, Selis Gulseven; Aslan, Zulkar; Adali, Mustafa Kemal; Karasalihoglu, Ahmet RifatPurpose Nasopharyngeal cancer is a type of malignancy originating from the epithelial cells lining the nasopharynx. In genetic and environmental factors, infection with Epstein-Barr virus is one of the particular factors held accountable for the etiopathogenesis. Human papillomavirus has been associated with cervical, anogenital, and oropharyngeal cancers. The aim of the present study is to demonstrate the presence and incidence of Epstein-Barr virus and human papillomavirus in patients with nasopharyngeal cancer. Methods The information collected for these patients included age at the time of biopsy, gender, alcohol consumption and smoking, and histopathological type of nasopharyngeal cancer. Only patients for whom nasopharyngeal biopsy was performed as punch biopsy were included in the study. In situ hybridization was performed with formalin-fixed, paraffin-embedded tissue sections for Human Papillomavirus and Epstein-Barr virus nucleic acids obtained by means of automated Ventana BenchMark Medical system Results Utilizing in situ hybridization with samples obtained from 56 patients diagnosed with nasopharyngeal cancer. Epstein-Barr virus was positive in 41 out of the 56 (73.2%) patients, while human papillomavirus was positive in 3 (5.4%), and 1 patient (1.8%) had co-infection. Thirty seven (90.2%) of the 41 patients positive for Epstein-Barr virus were Type-2 according to WHO, while 4 (9.8%) were Type-1. All three patients (100%) with Human Papillomavirus positivity were Type-2 according to WHO. Conclusions This study shows the close association between nasopharyngeal cancer and Epstein-Barr virus whereas such an association is not shown for Human Papillomavirus.Öğe Intracranial Complications of Chronic Suppurative Otitis Media(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2008) Yagiz, Recep; Adali, Mustafa Kemal; Tas, Abdullah; Uzun, Cem; Koten, Muhsin; Karasalihoglu, AhmetObjectives: To evaluate the clinical signs and symptoms, diagnosis-treatments, distributions and outcomes of patients with intracranial complications due to chronic suppurative otitis media (CSOM). Patients and Methods: Data of 42 patients (27 males, 15 gemales; mean age 31.3 years; range 9 to 74 years) diagnosed as intracranial complication due to CSOM were reviewed retrospectively. Patients were investigated on the basis of age, sex, symptoms, findings of otoscopic examination, complications, radiological evaluations, methods of management and findings at the operation. Results: Complications occurred predominantly in patients between 31 and 40 years of age (33.3%). Severe headache, nausea-vomiting, otalgia, purulent otorrhea and fever were the most common signs and symptoms. Meningitis was the most common (115 patients, 35.7%), brain abscess (14 patients, 33.3%) and lateral sinus thrombosis (10 patients, 23.8%) were second and third common complications. The overall mortality rate was 2.4% (in one patient who was comatose on admission), whereas it was 7.1% for patients with brain abscess. Conclusion: Intracranial complications of CSOM are still a serious problem due to life-threatening condition. If a patient with active CSOM has severe headache, nausea-vomiting, otalgia and fever, otogenic intracranial complication should be considered, and detailed evaluation should be performed for early diagnosis since the level of consciousness on admission is an important prognostic factor.Öğe Objective acoustic and aerodynamic analyses of voice after frontal anterior laryngectomy with epiglottoplasty(Aves, 2020) Koder, Ahmet; Karasalihoglu, Ahmet Rifat; Adali, Mustafa Kemal; Koten, Muhsin; Uzun, Cem; Yagiz, Recep; Tas, AbdullahObjective: !n this study, we aimed to pe:form an objective analysis of the acoustic and aerodynamic characteristics of vc.lice dunng the pteGpeiative peUod and the ea:ly and late postopetative pr'' r, at110Öğe Oropharyngeal Anthrax(Tubitak Scientific & Technological Research Council Turkey, 2008) Tas, Abdullah; Yagiz, Recep; Gurcan, Saban; Karaoglu, DenizAims: To report a rare case of oropharyngeal anthrax. Materials and Methods: A case report of oropharyngeal anthrax is presented together with the related world literature. Results: A 70-year-old female patient with respiratory distress and extensive swelling of neck, soft palate and uvula is presented. There was ecchymosis on the neck circumferentially. Bacillus anthracis grew in the blood culture. The patient died of toxemia and sepsis. Conclusions: Oropharyngeal anthrax is the least common form of anthrax. This acute illness should be added to the differential diagnosis of inflammatory lesion of the oropharynx with extensive neck swelling. Successful diagnosis of anthrax depends on a high level of suspicion.Öğe Otoacoustic Emissions in Young Children with Autism(Aves, 2017) Tas, Memduha; Yilmaz, Sule; Bulut, Erdogan; Polat, Zahra; Tas, AbdullahOBJECTIVE: The aim of this study is to investigate otoacoustic emissions (OAEs) in young children with autism compared with those in an agematched control group. MATERIALS and METHODS: Thirty-eight children with autism aged 3-6 years and 27 typically developing (normally developing) control subjects participated in this study. All the participants had normal hearing and middle-ear function. Auditory brainstem responses were used to determine the hearing status in the autism group. Transient-evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) were measured in the two groups. RESULTS: The TEOAE response level was higher in the autism group. Analysis of the DPOAE response showed that the mean emission levels at 1.5, 2, 3, and 6 kHz and signal/noise ratios at 2, 4, 6, and 8 kHz were higher in the autism group (p<0.05). The greatest between-group differences were observed in the DPOAE signal levels at 2, 3, and 6 kHz (p=0.000). No statistically significant difference was found between the noise levels in the autism and control groups (p>0.05). CONCLUSION: The emission responses in the autism group were higher than those in the control group. The increase in DPOAEs at high frequencies may be related to the higher outer cell activation in the autism group. Further studies with larger sample sizes comprising younger children are needed to confirm the result and investigate the possible association between the increased OAEs and auditory sensitivity reported in autism.Öğe Possible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Study(Galenos Yayincilik, 2017) Abayli, Cihan; Kul, Yusuf; Koten, Muhsin; Karasalihoglu, Ahmet Rifat; Tas, Abdullah; Yagiz, Recep; Bulut, ErdoganObjective: This study aimed to investigate possible ototoxicity associated with topical rifamycin application via electrophysiological tests and ultrastructural examinations. Methods: Electrophysiological assessment was performed with tympanometry, auditory brainstem response (ABR), and distortion product otoacoustic emission (DPOAE) measurements. This study was conducted on 40 ears of 20 guinea pigs that were detected to have normal hearing thresholds. The animals were randomly assigned to three groups: Group 1 (n=12) received 0.1 mL rifamycin, Group 2 (n=8) received 0.1 ml gentamycin, and Group 3 (n=20) received 0.1 mL physiological saline. The antibiotics and saline solutions were administered via intratympanic injections. After five injections every other day, electrophysiological tests were performed again on the 15th day. After electrophysiological measurements, the temporal bones of all guinea pigs were prepared for ultrastructural examinations and the cochlear surface morphology was examined by scanning electron microscopy (SEM). Results: The animals in group 3 did not show a statistically significant change in their DPOAE signal/noise ratio (SNR) or ABR thresholds (p>0.05). In groups 1 and 2, the reduction in the DPOAE SNR and the increase in the ABR threshold were statistically significant (p<0.05). Regarding SEM examination results, the animals in groups 1 and 2 showed statistically significant outer hair cell damage and cochlear degeneration due to the ototoxic effect of the drugs (p<0.05), whereas the animals in group 3 showed no significant damage (p>0.05). Conclusion: The results indicate that rifamycin application to the middle ears of guinea pigs has mild ototoxic effects on their inner ears.Öğe The results of tracheotomy in patients with prolonged intubation(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2008) Tas, Abdullah; Yagiz, Recep; Topcuoglu, Turgay; Kocyigit, Murat; Uzun, Cem; Karasalihoglu, Ahmet RifatObjectives: We evaluated early and late complications of tracheotomy in patients who underwent tracheotomy for prolonged entubation. Patients and Methods: This retrospective study included 227 patients (124 males, 103 females; mean age 47.2 years; range 3 to 85 years) who underwent tracheotomy for prolonged entubation during hospitalization at Reanimation and Intensive Care Unit, Coronary Intensive Care Unit, Cardiovascular Surgery Intensive Care Unit, Neurology Unit, and Chest Diseases Unit. There were 10 children and 217 adult patients. Patients who underwent tracheotomy for upper airway obstruction were excluded. Results: The mean duration of intubation was 10.4 days (range 9 to 13 days). Early complications included hemorrhage (n=15, 6.6%) and subcutaneous emphysema (n=3, 1.3%), and late complications included laryngotracheal stenosis (n=2, 3.2%) and difficult decannulation (n=1, 1.6%). Mortality due to tracheotomy did not occur. Conclusion: Establishing a tracheotomy in patients with prolonged intubation is a reliable surgical procedure with low complication risk, providing a safe ventilatory respiration.
