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Acute abdomen caused by brucellar hepatic abscess
(Elsevier Singapore Pte Ltd, 2007) Ibis, Cem; Sezer, Atakan; Batman, Alli K.; Baydar, Serkan; Eker, Alper; Unlu, Ercument; Kuloglu, Figen
Brucellosis is a zoonotic infection that is transmitted from animals to humans by ingestion of infected food products, direct contact with an infected animal, or aerosol inhalation. The disease is endemic in many countries, including the Mediterranean basin, the Middle East, India, Mexico, Central and South America and, central and southwest Asia. Human brucellosis is a systemic infection with a wide clinical spectrum. Although hepatic involvement is very common during the course of chronic brucellosis, hepatic abscess is a very rare complication of Brucella infection. We present a case of hepatic abscess caused by Brucella, which resembled the clinical presentation of surgical acute abdomen.
Amerikan Tiroid Birliği'nin 2015 kılavuzu ile neler değişti?
(2016) Makay, Özer; Kıvılcım, Taner; Sezer, Atakan
[Abstract Nıt Available]
Amyand Hernisi: Olgu Sunumu
(2010) Sezer, Atakan; Yağcı, Mehmet Ali; Hatipoğlu, Mehmet Rahmi
Amyand hernisi nadir görülen bir durum olup, fıtık kesesiiçinde apendiks vermiformisin bulunması olarak tanımlanır. Kasık fıtığı olgularının yaklaşık %1’ inde görülür. 53yaşında erkek hasta sağ kasık bölgesinde ağrı yakınmasıile acil servisimize başvurdu. Fizik muayenesinde inkarsere sağ inguinal hernisi olduğu tespit edilen hastanınkarın tomografsinde sağ inguinal herni kesesi içerisindeapendiks olduğu görüldü. Fıtık kesesi içerisinde çapı veboyutu artmış iltihaplı ve ödemli bir apendiks görülmesi veileoçekal bileşkede; apandiks kökünün çevresinde nekrotik alanlar olması üzerine sağ hemikolektomi, parsiyelincebarsak rezeksiyonu ve herni tamiri uygulandı. Hastapostoperatif 14. gün şifa ile taburcu edildi. İnkarsere inguinal herni kliniği çoğunlukla akut apandisitin belirti ve bulgularını maskeler ve bu nedenle preoperatif tanı koymakçok zor olabilir. Bu yazıda inkarsere inguinal herni nedeniyle opere edilen ve peroperatuvar Amyand hernisi tanısıkonan bir hasta ve konu ile ilgili literatür irdelenmiştir.
Breast Conserving Surgery and Sentinel Lymph Node Biopsy in Locally Advanced Breast Cancer: Single Center Experience
(Galenos Publ House, 2011) Sezer, Atakan; Alas, Rusen Cosar; Cicin, Irfan; Hoscoskun, Zeki; Tuncbilek, Nermin
Objective: Patients with locally advanced breast cancer may undergo breast conserving surgery after neoadjuvant chemotherapy. The aim of the study is to evaluate the results of locally advanced breast cancer patients who underwent breast conserving surgery, axillary dissection and sentinel lymph node biopsy in a single center. Material and Methods: 12 patients with locally advanced breast cancer stage IIIA/IIIB were included in the study between 2002-2009. The patients were given anthracycline-based regimen before surgery. Patients underwent breast conserving surgery, axillary dissection, and sentinel lymph node biopsy followed by radiotherapy. Results: There were five patients in stage IIIA, six in stage IIIB, and one in stage IIIC. Patients had received 3-6 regimen of FAC/FEC. Eight had partial and four had complete response. Five positive axilla were detected. The median value of the lymph nodes was 12 (n:8-19). Five patients underwent sentinel lymph node biopsy. The biopsy has failed in one patient and the median value of dissected sentinel node was 3.5 (n:3-4). Locoregional recurrence was not observed in any patients. The mean follow-up of the patients was 29.8 months and median time was 16 (n:2-80) months. Of the 12 patients 10 are alive and 2 were deceased. Conclusion: In selected locally advanced patients, breast conserving surgery and sentinel lymph node biopsy may be applied by a multidisciplinary approach, and excellent success may be achieved in those patients as in early breast cancer patients.
Calcified mass in right upper abdomen
(New Zealand Medical Assoc, 2010) Kavalci, Cemil; Sezer, Atakan; Sezenler, Eylem; Sungun, Mutasim
[Abstract Not Available]
Can Pediatric Surgeons Become Truly Experienced for Thyroid Surgery on a Universal Scale?
(Galenos Yayincilik, 2018) Inanc, Irem; Sezer, Atakan; Inan, Mustafa
[Abstract Not Available]
A case of parathyroid carcinoma presenting with bone metastasis: Brief review of the literature
(2012) Altun, Betül Uğur; Bilir, Betül Ekiz; Sezer, Atakan; Torun, Neşe; Atile, Neslihan Soysal; Çalık, Arzu; Güldiken, Sibel
Primer hiperparatiroidinin (PHP) en nadir nedenlerinden olan paratiroid karsinom (PK) (<%1) az rastlanan bir malignitedir. PKun yol açtığı hiperparatiroidi sıklıkla metabolik kemik hastalığı ve renal komplikasyonlara yol açar ve mortaliteyi yükseltir. Lokal servikal invazyon, servikal lenf nodlarına yayılım ve akciğer ve kemik metastazları sık görülür. Olgu: 56 yaşında kadın hasta sağ kalçada ağrı yakınmasıyla başvurdu. Çekilen düz grafisinde pelviste kırık hattı izlendi. Muayenede boyun sol yanda kitle palpe edildi. Tetkiklerinde düzeltilmiş Ca=15,5 mg/dl, P=2,1 mg/dl, iPTH=880,2 pg/ml olması üzerine servisimizde interne edilen hastanın boyun US ve MIBI ile paratiroid adenomu saptandı. Kalçaya yönelik MRda metastazla uyumlu kemik lezyonları saptanması nedeniyle MIBI tüm vücuda yönelik yapıldı ve iskelet sisteminde yaygın malign hastalık olarak raporlandı. PET-BT ile değerlendirilen hastada organ metastazı saptanmadı ancak kemik metastazları doğrulandı. PK ön tanısıyla hastaya paratiroidektomi yapıldı. Post-op aç kemik sendromu gelişen hastanın Ca replasman tedavisi düzenlendi. Kemik metastazlarına yönelik radyoterapisi yapılmaktadır. PK nadir ancak agresif bir malignitedir ve PK öntanısıyla yapılan agresif cerrahi eksizyon hastanın kür şansını arttıran önemli etkenlerdendir. Yüksek Ca ve PTH düzeyleri ve boyunda palpabl kitle malignite açısından uyarıcı olmalıdır. Postoperatif hipokalsemi krizi sıklıkla beklenmelidir. PK için bilinen bir medikal tedavi yoktur. Radyoterapi hem lokal nüks hem metastaz için kullanılan tedavi modalitesidir.
Comparison of clinicopathological features in patients with noninvasive follicular thyroid neoplasm with papillary-like nuclear features and follicular variant papillary thyroid cancer
(Medycyna Praktyczna Sp K Sp Zoo, 2020) Celik, Mehmet; Bulbul, Buket Y.; Can, Nuray; Ayturk, Semra; Tastekin, Ebru; Sezer, Atakan; Ustun, Funda
INTRODUCTION Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly defined entity accepted as a tumor precursor. OBJECTIVE We aimed to examine the features of patients diagnosed with follicular variant papillary thyroid carcinoma (FVPTC), which are classified as NIFTP in the recent classification. This study compares clinical, radiological, histopathological, and molecular features of NIFTP and FVPTC. PATIENTS AND METHODS A total of 247 patients with FVPTC were retrospectively examined and pathology specimens were reviewed. RESULTS Patients were divided into 2 groups (NIFTP group: 107 patients; FVPTC group: 140 patients). There was a difference in terms of the percentage of pathologic nodules with irregular borders detected on preoperative neck ultrasonography (NIFTP group: 6.5%, FVPTC group: 15.7%; P = 0.02). Central lymph node dissection specimens of 50 patients in the NIFTP group were normal, while 4 of 70 patients (5.7%) in the FVPTC group had lymph node metastasis (P = 0.14). In addition, multivariable analysis (binary logistic regression) showed that FVPTC was positively associated only with irregular borders and extrathyroidal extensions (P = 0.02 and P <0.001, respectively). CONCLUSIONS We suggest that patients diagnosed with NIFTP according to the new classification are considered low risk, and margin characteristics of the nodule detected on preoperative ultrasonography may be helpful in the differential diagnosis.
Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat
(Elsevier Science Inc, 2008) Memis, Dilek; Hekimoglu, Sevtap; Sezer, Atakan; Altaner, Semsi; Sut, Necdet; Usta, Ufuk
Objective: Curcumin has antioxidant, antitumor, and anti-inflammatory properties. However, it remains unknown whether curcumin has any protective effects on sepsis. The purpose of this study was to demonstrate whether curcumin prevents organ dysfunction in animals with sepsis. Methods: Rats were randomized into four groups. The control group (group I, n = 7) did not receive any treatment. The curcumin group (group II. n = 10) only received 1.2 g/kg of curcumin. Escherichia coli were injected into the remaining groups intraperitoneally after general anesthesia. Five hours after injection, 12 rats received placebo (group III), and 10 rats received 1.2 g/kg of curcumin (group IV) for 7 d. All rats were sacrificed on postsepsis day 8 and it midline laparotomy was performed. Livers, kidneys, and small bowels were excised for evaluation of the degree of inflammation and tissue alterations histopathologically. Results: In the liver, widespread hydropic degeneration of hepatocytes were seen in the sepsis group. There was no hydropic degeneration of hepatocytes and no portal inflammation ill the sepsis/curcumin group. With respect to the small bowel, the sepsis group showed edema and prominent intraepithelial infiltration of neutrophil leucocytes and plasma cells. Inflammation and hyperemia in the lamina propria in the sepsis/curcumin group were less than those in the sepsis group, With respect to the kidneys, the sepsis group showed severe acute tubular necrosis that was more restricted in the sepsis/curcumin group than in the sepsis group. Conclusion: curcumin reduced organ dysfunction in rats with experimentally formed sepsis. We propose that curcumin may he useful in the therapy of organ dysfunction due to sepsis, shock, and other diseases associated with local or systemic inflammation. (C) 2008 Elsevier Inc. All rights reserved.
Duodenal necrosis during nasogastric tube feeding: A case report
(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2007) Memis, Dilek; Sahin, Sevtap Hekimoglu; Sezer, Atakan
A case of duodenal necrosis during nasogastric tube feeding in a 45-year-old male patient hospitalized in intensive care unit with a diagnosis of acute respiratory distress syndrome is reported with a review of literature. Abdominal distension developed after several days of uneventful nasogastric tube feeding. At laparotomy patchy necrosis of the duedonum was found without signs of bowel obstruction or impaired mesenteric perfusion. In this case, the large doses of fentanyl, midazolam and dopamine given for sedation, were suspected to be a major contributing factor to the development of the necrosis by impairing mucosal per-fusion.
Dural sinus vein thrombosis in a patient with colon cancer treated with FOLFIRI/bevacizumab
(Wolters Kluwer Medknow Publications, 2009) Ozen, Alaattin; Cicin, Irfan; Sezer, Atakan; Uzunoglu, Sernaz; Saynak, Mert; Genchellac, Hakan; Karagol, Hakan
The adverse effects of regimes in cancer treatment have forced us to change to new targeted therapy options. Understanding these side effects, which can lead to discontinuation of the new therapy strategies, will allow the clinical management of these side effects and result in continuing therapies with effective medications. Bevacizumab, which is an IgG1 antibody against vascular endothelial growth factor, has side effects such as proteinuria, hypertension, venous and arterial thromboembolic events, and hemorrhage. This is the first reported case of dural sinus vein thrombosis, during the treatment with bevacizumab.
The effect of a flavonoid fractions diosmin plus hesperidin on radiation-induced acute proctitis in a rat model
(Medknow Publications, 2011) Sezer, Atakan; Usta, Ufuk; Kocak, Zafer; Yagci, Mehmet Ali
Background: To explore the protective effect of a flavonoid fractions diosmin + hesperidin (Daflon), against radiation-induced acute proctitis in an experimental rat model. Materials and Methods: Thirty four rats were divided into four groups. The rats in Group 1 received Daflon and underwent irradiation. The rats in Group 2 received no Daflon and underwent irradiation. The rats in Group 3 received Daflon and underwent sham irradiation. The rats in Group 4 received no Daflon and underwent sham irradiation. Daflon emulsion (100 mg/kg/day) was administered via an orogastric feeding tube to the rats in groups 1 and 3 starting from 1 day prior to irradiation until the euthanasia day (day 15 following irradiation). Radiation therapy was delivered on a cobalt-60 unit using a single fraction of 17.5 Gy defined at a depth of 1 cm through an anterior portal. Slides were examined by the same pathologist under a light microscope two times in a blinded manner. Results: When compared to group 2, the rats of Group 1 showed less glandular distortion and less mucosal inflammation with less infiltration of the crypt epithelia by the inflammatory cells (P < 0.001). A statistically significant increase in all parameters but muscular wall thickness was observed for the rats in Group 2 as compared to the group 3 and 4. Conclusions: Administration of a dose of 100 mg/kg/day of the diosmin + hesperidin resulted in decreased morphologic inflammatory changes. This drug may have protective effects against radiation-induced acute proctitis.
The effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot study
(Turkish Assoc Trauma Emergency Surgery, 2010) Sezer, Atakan; Memis, Dilek; Usta, Ufuk; Sut, Necdet
BACKGROUND In this pilot study, we aimed to investigate the effect of dexmedetomidine on liver tissues during experimental sepsis by histopathological examination. METHODS The animals were allocated randomly to four groups, two of which received endotoxin. In the Sepsis Group (n:10) and Dexmedetomidine/Sepsis Group (n:10), endotoxemia was induced by E. coli lipopolysaccharide derived from E. colt 0111: B4. Animals in the Control Group (n:10) received an infusion of 0.9% saline (1.0 mL.kg(-1).hr(-1)) intravenously. The Dexmedetomidine Group (n:10) and Dexmedetomidine/Sepsis Group received a bolus injection of 0.9% saline (1.0 mL/kg), followed by dexmedetomidine administration (infusion at 5 mu g.kg(-1).hr(-1)). All rats were euthanized at the 8th hour of endotoxin infusion. Histopathological examinations were performed on liver tissues. RESULTS In the liver, central venous congestion, congestion and dilation of the hepatic sinusoids and inflammation of the portal tracts were noted in the Sepsis Group. These parameters were seen slightly in the Sepsis/Dexmedetomidine group. There was a statistically significant difference between the Sepsis and Sepsis/Dexmedetomidine Groups (p<0.001). CONCLUSION Dexmedetomidine has a protective effect on liver tissues during experimental sepsis in the rat. We propose that dexmedetomidine sedation may be useful in the therapy of the liver dysfunction associated with sepsis and in other diseases related to local or systemic inflammation.
The effect of Saccharomyces boulardii on reducing irinotecan-induced intestinal mucositis and diarrhea
(Humana Press Inc, 2009) Sezer, Atakan; Usta, Ufuk; Cicin, Irfan
To investigate the efficiency of Saccharomyces boulardii on irinotecan-induced mucosal damage and diarrhea in rats, fifty rats were randomized into three groups with 20 rats in two study groups and 10 rats in the control group. Control group did not receive any treatment. Irinotecan (60 mg/kg) alone was administered intravenously once a day for four consecutive days to the rats of Group A. Throughout the experiment, Group B rats were additionally given Saccharomyces boulardii (800 mg/kg) for 3 days before administration of irinotecan and 7 days throughout the experiment. Delayed diarrhea was more severe in Group A than Group B (P = 0.009). The weight loss was 34.7 +/- A 3.8 mg for Group A, while it was 17.4 +/- A 1.7 mg for Group B (P < 0.001). Findings of mucositis most clearly appeared in the jejunum. Regarding edema (P = 0.003), leukocyte migration (P = 0.038), and inflammation (P = 0.006) significant recovery was detected in the mucosa of rats receiving Saccharomyces boulardii. Villous thickness was significantly greater in Group A than Group B (P < 0.001). The results indicate that Saccharomyces boulardii provided significant improvement in irinotecan-induced diarrhea and mucositis.
The Effects of Different Insufflation Pressures on Cerebral Oxygen Saturation in Patients Undergoing Laparoscopic Cholecystectomy
(Springer India, 2020) Inal, Mehmet Turan; Memis, Dilek; Sezer, Atakan; Turan, Nesrin
A pneumoperitoneum during laparoscopic procedures has deleterious effects on cerebral perfusion and oxygenation. Our aim was to assess the effects of different insufflation pressures on cerebral oxygen saturation (rSO(2)) using a noninvasive INVOS Cerebral Oximeter (Somanetics Corporation, USA) system. One hundred patients scheduled for laparoscopic cholecystectomy were included and divided into two groups: a 10 mmHg pneumoperitoneum group (group I) and a 14 mmHg pneumoperitoneum group (group II). The rSO(2)measurements were obtained preinsufflation, after insufflation, every 15 min after insufflation, and 10 min after desufflation. Hemodynamic variables and anesthesia and surgery times were recorded. Between the two groups, there were no statistically significant differences in terms of age, sex, weight, anesthesia times, or surgery times (p > 0.05). The hemodynamic variables were similar in the two groups (p > 0.05). The rSO(2)value changed over time, with a statistically significant between-group difference (p = 0.001). The preinsufflation rSO(2)value was 70.07 +/- 7.73 in group I and 72.21 +/- 6.58 in group II, with no significant between-group difference (p > 0.05). After insufflation, the rSO(2)value decreased to 69.60 +/- 7.74 in group I and 64.41 +/- 6.48 in group II, and the distinction was statistically significant (p < 0.001). A high-pressure pneumoperitoneum was associated with a greater decrease in rSO2 as compared to a low-pressure pneumoperitoneum. Thus, we suggest the use of a low-pressure pneumoperitoneum in patients with central nervous system pathologies.
The effects of different insufflation pressures on liver functions assessed with limon on patients undergoing laparoscopic cholecystectomy
(Oxford Univ Press, 2012) Eryylmaz, H. Barys; Memis, Dilek; Sezer, Atakan; Ina, Mehmet Turan
[Abstract Not Available]
The Effects of Different Insufflation Pressures on Liver Functions Assessed with LiMON on Patients Undergoing Laparoscopic Cholecystectomy
(Hindawi Ltd, 2012) Eryilmaz, H. Baris; Memis, Dilek; Sezer, Atakan; Inal, Andmehmet Turan
Purpose. Laparoscopic cholecystectomy has been accepted as an alternative to laparotomy, but there is still controversy regarding the effects of pneumoperitoneum on splanchnic and hepatic perfusion. We assessed the effects of different insufflation pressures on liver functions by using indocyanine green elimination tests (ICG-PDR). Methods. We analyzed 43 patients who were scheduled for laparoscopic cholecystectomy. The patients were randomly allocated to two groups. In Group I, the operation was performed using 10 mmHg pressure pneumoperitoneum. In Group II, 14 mmHg pressure pneumoperitoneum was used. The ICG-PDR measurements were made after induction (ICG-PDR 1) and after the end of the operation (ICG-PDR 2). Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin levels were all recorded preoperatively, 1 hour, and postoperative 24 hours after surgery. Results. The ICG-PDR 1 values for Groups I and II were as follows: 26.78 +/- 4.2% per min versus 26.01 +/- 2.4% per min (P > 0.05). ICG-PDR 2 values were found to be 25.63 +/- 2.1% per min in Group I versus 19.06 +/- 2.2% per min in Group II (P < 0.05). There was a statistically significant decrease between baseline and postoperative ICG-PDR values in Group II compared to Group I (P < 0.05). Statistically, there was an increase between baseline and postoperative 1st-hour serum AST and ALT level in Group II (P < 0.05) compared to Group I. No statistical differences were detected on postoperative 24st-hour serum AST and ALT levels and all the time bilirubin between groups (P > 0.05). Conclusion. In conclusion, the results show that 14 mmHg pressure pneumoperitoneum decreased the blood flow to the liver and increased postoperative 1st-hour serum AST and ALT levels. We think that 10 mmHg pressure pneumoperitoneum is superior to 14 mmHg pressure pneumoperitoneum in laparoscopic cholecystectomy.
Effects of Intraperitoneal Melatonin on Caustic Sclerosing Cholangitis Due to Scolicidal Solution in a Rat Model
(Elsevier, 2010) Sezer, Atakan; Hatipoglu, Ahmet Rahmi; Usta, Ufuk; Altun, Guelay; Sut, Necdet
BACKGROUND: Hydatid disease is a worldwide health problem. Treatment is surgical or percutaneous, using scolicidal agents. Caustic sclerosing cholangitis might develop after the contact of scolicidal agents with the biliary ducts. Melatonin, an antioxidant, anti-inflammatory, and anticarcinogenic agent, might be used in the treatment of caustic sclerosing cholangitis due to its possible preventive effects on fibrosis and cell damage. OBJECTIVE: The aim of the study was to investigate the effects of melatonin on an experimentally developed caustic sclerosing cholangitis with scolicidal solution (formalin) in a rat model. METHODS: Forty female Sprague-Dawley rats aged 11 to 13 weeks and weighing 250 +/- 30 g were randomly assigned to 1 of 4 groups of 10: formalin 5% at 0.5 mL/d + melatonin placebo; formalin placebo + intraperitoneal melatonin 10 mg/kg/d; formalin 5% at 0.5 mL/d + melatonin 10 mg/kg/d; and formalin placebo and melatonin placebo (control). Hepatobiliary function was assessed using dynamic scintigraphy with technetium-99m-mebrofenin on study day 60. The histology of the liver and biliary duct specimens was examined on study day 60. In each group, histopathologic alterations were scored as absent, slight, mild, or severe. RESULTS: Mean severity scores for parenchymal necrosis in the liver (P < 0.01), portal fibrosis (P < 0.01), biliary duct proliferation (P < 0.001), cholangitis/pericholangitis (P < 0.01), hyperemia in the biliary ducts (P < 0.01), and fibrosis (P < 0.01) were significantly lower in rats treated with formalin + melatonin compared with those treated with formalin alone. No significant differences were observed between the 3 treatment groups with respect to t(1/2), a parameter used to assess the secretion function of the hepatocytes. However, the t(1/2) was significantly longer in the treatment groups compared with controls (P < 0.001). CONCLUSION: In this experimental study in a rat model of caustic sclerosing cholangitis, the histopathologic and scintigraphic findings suggested that melatonin is effective in attenuating the damage caused by scolicidal agents on the liver and biliary ducts. (Curr Ther Res Clin Exp. 2010;71:118-128) (C) 2010 Excerpta Medica Inc.
The Effects of Sirolimus on Target Organs During Mesenteric Ischemia and Reperfusion Damage in an Experimental Rat Model
(Elsevier Science Inc, 2011) Sagiroglu, Tamer; Sezer, Atakan; Altaner, Semsi; Umit, Hasan; Yalta, Tulin; Yagci, Mehmet Ali
BACKGROUND: Mesenteric ischemia and reperfusion (I/R) syndrome (MIRS) has been considered a clinicopathologic entity associated with a variety of clinically severe conditions with decreased intestinal blood flow and has been known to induce I/R damage in various organs. Sirolimus (SRL), a macrolide antibiotic isolated from a strain of Streptomyces hygroscopicus, is a potent and nonnephrotoxic immunosuppressant. OBJECTIVE: This study was designed to investigate the potential impact of sirolimus on MIRS-induced I/R damage in renal, intestinal, pulmonary, and hepatic tissues in an experimental rat model. METHODS: Twenty-four male Sprague-Dawley rats, aged 6 to 8 weeks and weighing 280 (+/- 20 g), were studied. Using computer-generated random numbers, rats were assigned to 1 of the following 3 groups: group 1 (I/R group, n = 8), group 2 (I/R + sirolimus group, n = 8), and group 3 (control group, n = 8). Sirolimus, in a 1 mg/mL (60 mL) solution, was administered intraperitoneally in a dose of 1.5 mg/kg/d to the rats assigned to group 2 starting from 3 days before the surgical procedure. In surgery, a laparotomy was performed to clamp the superior mesenteric artery and, thus, induce bowel ischemia in groups 1 and 2. After 60 minutes of ischemia, the microvascular clamp on the superior mesenteric artery was removed for 3 hours of reperfusion. Soon after experimental induction of MIRS, bowel, lung, kidney, and liver specimens from each animal were harvested for both biochemical and histopathologic analysis. RESULTS: There were statistically significant differences between groups 1 and 3 with regard to degrees of intestinal (P < 0.001), hepatic (P = 0.001), renal (P < 0.001), and pulmonary (P = 0.01) I/R damage. The lung specimens from group 2 had less inflammation and perivascular edema formation compared with specimens from group 1, but no statistical significance was observed between the groups (P < 0.33). There were statistically significant differences between groups 1 and 2 with regard to degrees of intestinal, hepatic, and renal I/R damage (P = 0.001 for all). CONCLUSION: The findings of the present study demonstrate the attenuating effects of sirolimus on I/R damage in the intestine and remote organs, including the liver and kidney in the setting of MIRS in an experimental rat model. As a therapeutic implication, the utility of sirolimus may be of clinical value in procedures associated with a high likelihood of I/R damage, including major abdominal operations and renal transplantation. However, whether these results apply to humans is unclear. Additional experimental and clinical studies are warranted to confirm the clinical utility of sirolimus in conditions potentially associated with I/R damage. (Curr T her Res Clin Exp. 2011;72:79-93) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.
Gastric damage related to radioactive iodine treatment and the protective effect of amifostine.
(Scientific Publishers India, 2017) Sezer, Atakan; Celik, Mehmet; Usta, Ufuk; Altun, Gulay Durmus
Introduction: The aim of this study was to evaluate the gastric damage related to high dose radioactive iodine treatment during thyroid cancer treatment in an experimental rat model and evaluate histopathologically the radioprotective effect of amifostine. Methods and findings: 40 adult rats were enrolled into the study. Radioactive iodine treatment with 30 mCi/kg I-131 was applied via orogastric tube simulating radioiodine ablation treatment (RAI) in thyroid cancer in all rats. After RAI subjects were divided into 2 groups: Group Orogastric RAI (Group OG, n: 20): Rats received no radioprotective agent but serum physiologic. Group Amifostine RAI (Group AP, n: 20): Rats received 200 mg/kg amifostine intraperitoneally 30 minutes before I-131 application. On the 1st, 3rd, 5th and 7th days of experiment rats were sacrificed for histopathological evaluation. Gastric tissues were excised and tissue damage was assessed by using histopathological scoring. Total pathology score revealed a significant change on the 7th day. The subjects in Group OG had histopathological changes, while only one subject in Group AP was found to have pathologic changes (X2=39.7 df (28), p=0.04). The common histopathological findings were striking mucosal and intraepithelial leucocytic infiltration together with thinning of the mucosa, regenerative changes, and reactive atypia. Conclusions: RAI treatment causes gastric mucosal injury and amifostine was found to decrease radioactive iodine treatment related gastric damage.

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