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Öğe 99mTc(V)-DMSA scintigraphy in monitoring the response of bone disease to vitamin D3 therapy in renal osteodystrophy(Springer, 2002) Sarikaya, A; Sen, S; Hacimahmutoglu, S; Pekindil, GRenal osteodystrophy (ROD) is a common and serious complication for uremic patients and patients are treated with 1,25-dihydroxy vitamin D-3. The bone scanning agent Tc-99m-phosphate has also been used to evaluate in ROD but it is not clear that bone scintigraphy has a role in the follow-up of treatment. In this study Tc-99m(V)-DMSA scintigraphy was performed in eleven patients [age 40.7 +/- 17.3 (mean +/- SD) yr] with ROD before and after vitamin D-3 therapy. Images were obtained after hemodialysis performed following tracer injection to maintain normal blood levels of the radiopharmaceutical and to reduce soft tissue activity. Lumbar vertebra-to-soft tissue uptake ratios (LUR) were quantified with the planar Tc-99m(V)-DMSA images. Alkaline phosphatase and parathyroid hormone levels after treatment had significantly decreased compared with pre-therapy. In all patients there was visually decreased uptake in bone structures after treatment. After treatment the mean LUR ratio was significantly lower than those of before treatment (3.59 +/- 2.63 vs. 1.65 +/- 0.62; p = 0.01). LUR values were correlated with pre-therapy alkaline phosphatase and parathyroid hormone. These findings indicate that Tc-99m(V)-DMSA scintigraphy is sensitive in evaluating the response of ROD to vitamin D-3 therapy.Öğe Antioxidant status and lipid peroxidation in hemodialysis patients undergoing erythropoietin and erythropoietin-vitamin E combined therapy(Taylor & Francis Ltd, 1999) Inal, M; Kanbak, G; Sen, S; Akyüz, F; Sunal, EIn this study, plasma and red blood cell (RBC) antioxidant status and plasma lipid peroxidation were investigated in 46 hemodialysis patients. In addition, the effect of erythropoietin (EPO) and EPO-vitamin E combination therapy on plasma and RBC antioxidant status, and plasma lipid peroxidation were examined. There were 10 healthy subjects in the control group and 10 hemodialysis patients in the untreated group. The third group included 36 hemodialysis patients that were given EPO (100 U/kg) for 3 months, 3 times per week. The fourth group included 36 hemodialysis-patients from the EPO group that were given EPO at a 50% decreased dose + vitamin E (300 mg/day) for 3 months. MDA levels in the untreated group, the EPO group and the EPO + vitamin E groups were found to be higher than the control group (p < 0.001, in both). Furthermore, MDA levels in both of the treatment groups were lower when compared to the untreated group (p < 0.001, in both). Plasma vitamin E levels in the untreated, the EPO group and EPO + vitamin E groups were lower than the control group (p < 0.001). In contrast, plasma vitamin E levels in the treatment groups were higher in comparison with the control group (p < 0.05). SOD activities in the untreated, the EPO group and the EPO + vitamin E groups were found to be lower than the control group (p < 0.001). SOD activities in the treatment groups were higher than the control group (p < 0.001). The SOD activities in the EPO + vitamin E group increased when compared to the EPO group (p < 0.001). CAT activities in the untreated, the EPO group and the EPO + vitamin E groups were found to be lower than the control group (p < 0.001 in untreated and EPO groups, p < 0.01 in EPO + vitamin E group). CAT activities in EPO and EPO + vitamin E groups were increased when compared to the untreated group (p < 0.01). In conclusion, our findings have shown that antioxidant status decreased and lipid peroxidation increased in hemodialysis patients. EPO has an antioxidant effect on the RBC and plasma antioxidant status, and plasma lipid peroxidation. These effects were moderately increased by the combination of vitamin E and EPO.Öğe A case of acute tubular necrosis with intestinal visualization of Tc-99m DMSA(Lippincott Williams & Wilkins, 2000) Yüksel, M; Üstün, F; Salan, A; Sen, S; Berkarda, S[Abstract Not Available]Öğe Effects of chronic renal failure and dialysis on lipoproteins(Elsevier Sci Ireland Ltd, 1999) Sen, S; Arikan, E; Altun, A; Çakir, E; Isikalp, H[Abstract Not Available]Öğe The effects of trandolapril and losartan on glomerulo-tubuler function in primary hypertension(Oxford Univ Press, 2005) Ustundag, S; Sen, S; Sut, N; Ciftci, S[Abstract Not Available]Öğe Endothelial damage and hemostatic markers in patients with uncomplicated mild-to-moderate hypertension and relationship with risk factor's(Westminster Publ Inc, 2005) Arikan, E; Sen, SEndothelial damage, high fibrinogen levels, and platelet activity are the important accelerating factors for the development of hypertension (HT). von Willebrand factor (vWF; endothelial damage marker), fibrinogen levels, and platelet aggregability were compared between patients with uncomplicated, mild-to-moderate hypertension and healthy subjects. The relationship between traditional cardiovascular risk factors and endothelial damage and prothrombotic state was evaluated. One hundred sixty-nine (54 males, 115 females) patients with untreated and uncomplicated mild-to-moderate HT, and age, gender, and body mass index-matched 124 (58 males, 83 females) healthy subjects were enrolled in this study. Plasma vWF, fibrinogen levels, adenosine diphosphate-induced platelet aggregability, insulin, glucose, serum lipids, and uric acid were measured. Patients with HT had significantly increased fibrinogen, vWF, platelet number and aggregability induced by adenosine diphosphate, triglycerides, total/HDL-C, glucose, uric acid levels, and insulin resistance than control group. vWF and hemostatic markers were comparable between smoker and nonsmoker subjects. Platelet aggregability was positively related to systolic and diastolic blood pressure, and vWF. Fibrinogen was positively associated with body mass index (BMI), systolic and diastolic blood pressure, total cholesterol (TC), uric acid, vWF, and insulin resistance. vWF was significantly related to age, systolic blood pressure, TC, LDL-C, and total/HDL-C. Systolic blood pressure was independently related to vWF. vWF and diastolic blood pressure were significant predictors for adenosine diphosphate-induced platelet aggregability. Systolic blood pressure and vWF were independent predictors for fibrinogen levels. Uncomplicated mild-to-moderate HT had endothelial damage and is associated with a prothrombotic state. Traditional cardiovascular risk factors such as age, BMI, dyslipidemia, and insulin resistance are important contributors to the development of endothelial damage and a prothrombotic state. Therefore, it is important to control these cardiovascular risk factors along with proper treatment of HT for preventing target organ damage in mild-to-moderate HT.Öğe Evaluation of skeletal muscle metabolism and erythropoietin treatment response in patients with chronic renal failure with 99mTc-sestamibi leg scintigraphy(Springer Verlag, 1999) Sarikaya, A; Sen, S; Çermik, TF; Birtane, M; Berkarda, S[Abstract Not Available]Öğe Evaluation of skeletal muscle metabolism and response to erythropoietin treatment in patients with chronic renal failure using 99Tcm-sestamibi leg scintigraphy(Lippincott Williams & Wilkins, 2000) Sarikaya, A; Sen, S; Çermik, TF; Birtane, M; Berkarda, SIt is well known that uraemia affects skeletal muscle metabolism. This has been attributed to a variety of causes, including anaemia, vitamin D, carnitine deficiency and hyperparathyroidism. The aim of this study was to ascertain whether Tc-99(m)-sestamibi leg scintigraphy is useful in the evaluation of skeletal muscle metabolism and the monitoring of treatment response in uraemic myopathy. Forty patients with chronic renal failure and 24 normal controls underwent examination. Fifteen patients with chronic renal failure received erythropoietin treatment. Tc-99(m)-sestamibi leg scintigraphy was performed in all subjects and in 15 patients after therapy. The calf-to-ankle uptake ratio was calculated by semi-quantitative analysis and normalized to lean body mass. The normalized uptake ratios were significantly different between patients and controls. After erythropoietin therapy, there was a significant increase in the normalized uptake ratios compared with pre-therapy. Our results suggest that Tc-99(m)-sestamibi leg scintigraphy is useful in the assessment of muscle metabolic abnormalities and the effect of treatment in uraemic myopathy. ((C) 2000 Lippincott Williams & Wilkins).Öğe The relationship between the levels of plasma total homocysteine and insulin resistance in uncomplicated mild-to-moderate primary hypertension(Nature Publishing Group, 2006) Ustundag, S; Arikan, E; Sen, S; Esgin, H; Ciftci, SPrimary hypertension ( HT) is the most frequent independent risk factor for cardiovascular disease. It was demonstrated that plasma total homocysteine ( tHcy) is an important and modifiable cardiovascular risk factor, which correlates with the severity of atherosclerotic disease, 1 despite some discordant results. 2 Although data supporting the cause-effect relationship between HT and tHcy are limited, tHcy may play a role in the pathogenesis of HT.Öğe Salivary function in patients with chronic renal failure undergoing hemodialysis(Japanese Society Nuclear Medicine, 2002) Kaya, M; Çermik, TF; Üstün, F; Sen, S; Berkarda, SPurpose: The aim of this study was to evaluate the changes in salivary gland function in patients with chronic renal failure (CRF) undergoing hemodialysis. Methods: The group consisted of 23 patients with CRF (13 female, 10 males mean age: 40 +/- 13 yr) and 14 healthy control subjects (mean age: 40 +/- 13 yr). All underwent dynamic salivary gland scintigraphy with gustatory stimulation, After intravenous administration of Tc-99m pertechnetate, first. perfusion images at 2 seconds per frame were acquired for I minute, then dynamic images at 1 minute per frame were acquired for 45 minutes, At 30 minutes after injection, 10 ml lemon juice was given for 15 minutes as a gustatory stimulus. We obtained time-activity curves derived from regions of interest centered over the four major salivary glands. The following functional indices were calculated for each gland: the time of maximum radioactivity (T-max) for the prestimulated period, the time of minimum radioactivity (T-min), as an indicator of velocity of secretion after stimulation, and the Lem E-5% value as an indicator of the secretion function. Results: When the patients with CRF undergoing hemodialysis were compared to the controls, there were statistically significant differences in T-max, T-min and Lem E5% values for bilateral parotid glands, and Train values for bilateral submandibular glands (p < 0.05), there were no statistically significant differences in Tmax and Lem E5% values for bilateral submandibular glands. There were also significant differences in T-max and Lem E5% values for bilateral parotid glands between mild oral problems and severe oral problems in patients with CRF (undergoing hemodialysis). Conclusion: In this study, prolonged T-max and T-min values, and decreased Lem E5% values for parotid glands and prolonged T-min values for submandibular glands on salivary scintigraphy pointed out decreased parenchymatous and excretory function in patients with CRF undergoing hemodialysis.
