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    Cardiac and Liver Marker Alterations After Laparoscopic Gynaecologic Operations
    (Aves, 2015) Sinikoglu, Nadir Sitki; Gumus, Funda; Sanli, Nalan; Totoz, Tolga; Alagol, Aysin; Turan, Nesrin
    Objective: In our study, we aimed to investigate the effect of laparoscopic procedures in which the abdominal cavity at a Trendelenburg position of 15 degrees was insufflated with CO 2 on cardiac and liver markers. Methods: Forty patients scheduled for laparoscopic gynaecological surgery were included in the study. Venous blood samples were taken the day before operation and 6 hours after surgery, and later, lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase-MB (CK-MB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), myoglobin (MY) and d-dimer (d-D) were measured. Results: There was no statistically significant difference in the values of preoperative and postoperative ALT (16.8 +/- 9.4 and 17.8 +/- 9.3; p= 0.579), AST (19.4 +/- 7 and 20.9 +/- 7.6; p=0.361) and ALP (65.2 +/- 16.2 and 63.3 +/- 16.9; p=0.609), but LDH (385.1 +/- 117.3 and 460.6 +/- 156.3; p=0.003), CK (113.8 +/- 138.5 and 247.9 +/- 283.5; p=0.0001), CK-MB (22.8 +/- 13.3 and 28.7 +/- 16; p= 0.011), MY (28.1 +/- 12.9 and 138.8 +/- 129; p=0.0001) and d-D (509.5 +/- 815: 1026 +/- 1054; p=0.0001) increased significantly. Conclusion: After laparoscopic operations in the Trendelenburg position, postoperative serum ALT, AST and ALP levels, remained unchanged, when compared to preoperative values, but LDH, CK, CK-MB, myoglobin and d-dimer values increased significantly.