Yazar "Salt, Semra Ayturk" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus
    (Dove Medical Press Ltd, 2023) Boz, Ibrahim Bekir; Salt, Semra Ayturk; Salt, Omer; Sayin, Niyazi Cenk; Dibirdik, Ilker
    Purpose: This study sought to investigate whether asprosin can be used in the diagnosis of GDM or for diagnostic purposes in high-risk pregnancies, along with a review of other parameters that may be associated with serum asprosin levels. Patients and Methods: The study investigated the association between gestational diabetes mellitus (GDM) and asprosin levels. A total of 93 participants; 30 patients with GDM, 33 healthy pregnant women with normal glucose tolerance (NGT), and 30 healthy non-diabetic women (control group) at the Endocrinology and Metabolic Diseases outpatient clinic of a tertiary care university hospital were enrolled in the study. Patients with GDM and NGT were examined in terms of GDM between the 24th and 28th week of pregnancy (2nd trimester). Patient data were collected during routine examinations, and asprosin levels were measured using the ELISA method. All participants underwent testing for measurements of serum hemoglobin, insulin, C-peptide, fasting plasma glucose, and glycated hemoglobin (HbA1c) levels following a fasting period of at least eight hours. Results: Asprosin levels were higher in pregnant women with NGT and with GDM versus controls (Control-NGT asprosin, p = 0.001; Control-GDM asprosin, p = 0.001). Pregnant women with GDM had higher asprosin levels than those with NGT (p = 0.001). In detecting GDM in pregnant women, an asprosin cutoff value of >31.709 ng/mL yielded a sensitivity of 93.3%, specificity of 90.9%, positive predictive value of 90.3%, and negative predictive value of 93.75% (p < 0.001). Conclusion: Serum asprosin levels can potentially be used as a marker in the diagnosis of GDM.
  • Küçük Resim Yok
    Öğe
    URINE IODINE EXCRETION IN PATIENTS WITH PAPILLARY THYROID CANCER: EVALUATION OF THE RELATIONSHIP WITH THE PRESENCE OF A BRAF MUTATION
    (Polish Society Magnesium Research, 2020) Celik, Mehmet; Guldiken, Sibel; Salt, Semra Ayturk; Bulbul, Buket Yilmaz; Kucukarda, Ahmet; Can, Nuray; Tastekin, Ebru
    Iodine is an essential element for the production of thyroid hormones. In recent years, it has been suggested that excessive consumption of iodine may play a role in the pathogenesis of papillary thyroid cancer (PTC). In addition, studies have suggested that high iodine consumption is an important risk factor for the formation of a BRAF mutation in the thyroid gland. A prospectively designed study included 132 cases scheduled for thyroidectomy for various reasons. Urine iodine levels of all patients were examined before the operation. The iodine excretion levels of the patients were grouped according to the median urinary iodine concentration determined in community screenings (those with <100 mu g L-1 low iodine excretion, those with 100-199 mu g L-1 normal iodine excretion, those with 200-299 mu g L-1 high iodine excretion). Patients were divided into 3 groups according to the post-operative pathology results. As a result of thyroid histopathology, benign (n: 44), PTC (n: 88) (BRAF (+): 44 and BRAF (-): 44) cases were included in the study. BRAF mutations in patients diagnosed with PTC were evaluated using the Real Time PCR Melting Curve Analyzer method. The relationship between urinary iodine excretion levels and clinical, histopathological and BRAF positivity was examined. In our study, no difference was found in urinary iodine excretion between patients with and without PTC. Hashimoto's thyroiditis was observed more frequently in patients with PTC (p=0.023). In addition, Hashimoto's thyroiditis was statistically more frequently detected in the BRAF (-) group compared to the BRAF (+) and control group (p=0.034). Despite studies suggesting that high iodine consumption is important in PTC pathogenesis, we did not find a relationship between the mutation and iodine consumption, which plays an important role in the development of PTC.