Yazar "Puyan, Fulya Oz" seçeneğine göre listele
Listeleniyor 1 - 20 / 35
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe 18F-FDG PET/CT Imaging of Burkitt Lymphoma Presenting With Unusual Muscle Involvement(Lippincott Williams & Wilkins, 2016) Serim, Burcu Dirlik; Eren, Tuba Gurleyen; Puyan, Fulya Oz; Altun, Gulay Durmus[Abstract Not Available]Öğe Anaplastic variant of diffuse large B-cell lymphoma associated with cutaneous fistulas; an unusual presentation(Zerbinis Medical Publ, 2014) Pamuk, Gulsum Emel; Tasci, Murat; Uyanik, Mehmet Sevki; Akker, Mustafa; Puyan, Fulya Oz[Abstract Not Available]Öğe A case of cebocephaly associated with abnormal genitalia(Elsevier Ireland Ltd, 2007) Duran, Ridvan; Aladag, Nukhet; Vatansever, Ulfet; Acunas, Betul; Puyan, Fulya Oz; Varol, Fusun G.Holoprosencephaly is frequently accompanied by midline facial abnormalities such as hypotelorism, cyclopia, etmocephaly, and cebocephaly. Cebocephaly is a very rare congenital anomaly combining alobar holoprosencephaly, ocular hypotelorism, and a proboscis-like nose with single nostril. There is only one cebocephaly case with abnormal genitalia. We report to our knowledge the second case of cebocephaly associated with abnormal genitalia in the relevant literature. (C) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe CD30 positive T-cell lymphoproliferative disorder: A case report(Springer, 2007) Puyan, Fulya Oz; Tekgunduz, Emre; Ilgili, Aysegul; Pamuk, Gulsum; Yalcin, Omer; Dogan, Oner[Abstract Not Available]Öğe Chondrodermatitis Nodularis Helicis Chronica: Answer of the Last Issue Case Question(Ortadogu Ad Pres & Publ Co, 2010) Arican, Ozer; Piskin, Suleyman; Onver, Nese; Puyan, Fulya Oz[Abstract Not Available]Öğe Clinicopathological and molecular analyses of uterine carcinosarcomas using next-generation sequencing: A single-center experience(Wolters Kluwer Medknow Publications, 2023) Erdogan, Ezgi Genc; Yalta, Tuelin D.; Can, Nuray; Sut, Necdet; Tastekin, Ebru; Usta, Ufuk; Puyan, Fulya OzBackground: Uterine carcinosarcomas (UCS) constitute 3-4% of all uterine malignancies and 16% of deaths caused due to uterine neoplasms. Aim: In this study, we aimed to perform DNA-based mutation analysis in 12 genes (KRAS, NRAS, EGFR, C-KIT, BRAF, PDGFRA, ALK, ERBB2, ERBB3, ESR1, RAF1, PIK3CA) to determine the molecular subtypes of UCS using next-generation sequencing (NGS) in patients with aggressive UCS and poor prognosis. We aimed to compare the results of our analysis with clinicopathological data to contribute to the development of targeted therapy approaches related to the molecular changes of UCS. Materials and Methods: In this study, we included 12 cases diagnosed with uterine carcinosarcomas and examined the changes in oncogenes that play a role in UCS pathogenesis. For the analysis of mutation, the clinicopathological data were compared with the variations in the DNA-based gene panel consisting of 12 genes and 1237 variants in the UCS using the NGS method. Results: EGFR mutation was found in 91.7% of the cases, mutation in 41.7%, PDGFRA mutation in 25%, KRAS and PIK3CA mutation in 16.7%, and C-KIT mutation in 8.3% of the cases. Although no statistical significance was found between the detected mutation and clinicopathological data, it was concluded that PDGFRA mutation might be associated with advanced-stage disease development. Conclusion: This study's findings regarding different molecular types of UCS and information on oncogenesis of UCS can provide inferences for targeted therapies in the future by identifying targetable mutations representing early oncogenic events and thereby contribute toward further studies on this subject.Öğe Clonal Hematopoiesis in Multiple Myeloma, Relations with Treatment Toxicity(Cig Media Group, Lp, 2021) Gulsaran, Sedanur Karaman; Umit, Elif Gulsum; Bas, Volkan; Baysal, Mehmet; Puyan, Fulya Oz; Demir, Ahmet Muzaffer[Abstract Not Available]Öğe Dramatic response to crizotinib in a breast cancer patient with ALK gene rearrangement(Lippincott Williams & Wilkins, 2022) Kus, Tulay; Aktas, Gokmen; Oktay, Cemil; Puyan, Fulya Oz; Tastekin, EbruRearrangements of the anaplastic lymphoma kinase (ALK) gene are present in 3-5% of non-small-cell lung cancer (NSCLC), while it was 0.2% in NSCLC tumors. Due to its low frequency, it is extremely challenging to conduct randomized clinical trials of ALK-targeted therapies in NSCLC tumors. In the present case, we describe the first reported case of triple-negative breast cancer (TNBC) harboring the ALK fusion mutation that responded to ALK-targeted therapy after progression with two lines of chemotherapy. Searching for ALK gene rearrangement or other fusion, especially in patients with chemotherapy-resistant TNBC, opens the door to new treatment strategies.Öğe The Effect of Exogenous Melatonin on Blood Glucose in A Model of Experimental Chronic Sleep Deprivation(Wiley, 2023) Gul, Tugba Kizil; Kaya, Oktay; Puyan, Fulya Oz; Ozturk, Levent[Abstract Not Available]Öğe Effect of Lidocaine on Reducing Injury in a Rat Electrical Burn Model(Lippincott Williams & Wilkins, 2012) Benlier, Erol; Eskiocak, Sevgi; Puyan, Fulya Oz; Sikar, Emel Yurdakul; Kandulu, Huseyin; Omurlu, Imran Kurt; Top, HusamettinElectrical injuries induce progressive tissue loss. We evaluated the effect of lidocaine on tissue necrosis after electrical burn injuries. Forty-two male Wistar albino rats (250-300 g) were divided into 3 groups [Group A (n = 6), control group without an electrical burn injury; and Groups B (n = 18) and C (n = 18), electrical burn injury groups without and with lidocaine therapy, respectively]. Three separate analyses were performed at different time points on 6 of 18 rats from Groups B and C at each time point. Electrical burns were induced by applying 220 V AC between the left upper and right lower extremities for 10 seconds. Myeloperoxidase and malondialdehyde levels were measured in skin and muscle biopsy specimens after the first hour, fresh and dry weight differences in the amputated extremities were calculated after 24 hours, and live and necrotic tissue areas were measured at 7 days after burn injury. We found that lidocaine reduced edema, the number of neutrophils, and neutrophil damage in tissues. We conclude that lidocaine decreased the amount of necrotic tissue caused by electric injury.Öğe The effect of melatonin on cadmium-induced renal injury in chronically exposed rats(Aves, 2009) Kaplan, Mustafa; Atakan, Irfan Huseyin; Aydogdu, Nurettin; Aktoz, Tevfik; Puyan, Fulya Oz; Seren, Gulay; Tokuc, BurcuObjective: This study was designed to investigate the effects of melatonin as an antioxidant, in prevention and treatment of cadmium (Cd)-induced renal toxicity in rats. Materials and methods: Fifty adult male Sprague-Dawley rats weighing 340 to 370 g were used. Renal toxicity was induced with the use of 200 mu g/ml of cadmium chloride in tap water. Ten rats were assigned to receive only tap water as the control group for three months and seven days. Two study groups were designed. To investigate the ability of melatonin to prevent Cd damage (Study 1), 10 rats received Cd and 10 rats received Cd plus 0.02% co-treatment melatonin in tap water for three months. To test whether melatonin would reverse CD-induced damage to the kidney (Study 2), 10 rats received Cd in tap water for three months+7 days, and 10 rats received Cd for three months followed by administration of high-dose (0.08%) melatonin in tap water for seven days. Results: Cadmium exposure significantly increased the kidney malondialdehyde (MDA) levels, as a marker of lipid peroxidation, decreased the kidney superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities, increased Cd concentrations in the renal cortex, but did not change glomerular filtration rate (GFR) and fractional excretion of sodium (FE-Na). In Study 1, melatonin decreased MDA levels, increased SOD, CAT and GSH-Px activities. In Study 2, melatonin decreased the kidney MDA levels, increased the SOD activity, but did not change the CAT and GSH-Px activities. Kidney accumulation of Cd did not change in both melatonin-treated groups. Histopathologically, Cd intake affected proximal tubules of the nephron more than the glomerular parts. Melatonin did not change these alterations. Conclusion: Our findings suggest that Cd-induced renal toxicity is related with oxidative stress and exogenously administrated melatonin might reduce the toxic effects of Cd on kidney without any reduction in tissue Cd burden.Öğe The effects of methylene blue on renal scarring due to pyelonephritis in rats(Springer, 2007) Aksu, Burhan; Inan, Mustafa; Kanter, Mehmet; Puyan, Fulya Oz; Uzun, Hafize; Durmus-Altun, Gulay; Gurcan, SabanThe aim of this study was to evaluate the efficiency of methylene blue (MB) in preventing renal scar formation after the induction of pyelonephritis (PNP) in a rat model with delayed antimicrobial therapy. An inoculum of the K-12 strain of Escherichia coli was injected into both kidneys. Control groups received isotonic saline instead of bacterial solution. Four equal groups were then formed: the PNP group was untreated and the PNP ciprofloxacin (CIP) treated group was treated only with CIP intraperitoneally (i.p.) starting on the third day following bacterial inoculation. In the PNP (MB)-treated group, MB was given i.p., and in the PNP MB + CIP-treated group, MB + CIP were administered i.p.. In the sixth week following bacterial inoculation, all rats were sacrificed, and both kidneys of the rats in all groups were examined biochemically and histopathologically for renal scarring. Renal scar was significant in the groups treated with MB alone or MB + CIP combination compared with untreated or antibiotic only groups. Delayed treatment with antibiotics had no effect on scarring. These results suggest that the addition of MB to the delayed antibiotic therapy might be beneficial in preventing PNP-induced oxidative renal tissue damage.Öğe Expression of Bcl-2 and Ki-67 in tamoxifen-associated endometrial polyps: Comparison with postmenopausal polyps(Karger, 2006) Altaner, Semsi; Gucer, Fatih; Tokatli, Fusun; Guresci, Servet; Ozdemir, Cigdem; Puyan, Fulya Oz; Kutlu, KemalBackground: The aim of this study was to evaluate the expression of Bcl-2 and Ki-67 in tamoxifen (TAM)-associated endometrial polyps and postmenopausal polyps. Material and Methods: For this purpose, a retrospective analysis of paraffin-embedded specimens was carried out. Polyps of 20 postmenopausal and 14 TAM-treated patients, 11 simple endometrial hyperplasia, 10 atypical complex endometrial hyperplasia and 8 endometrial adenocarcinoma specimens were included in the study. Hematoxylin/eosin-stained sections were evaluated. Immunohistochemical staining was performed to investigate the expression of Bcl-2 protein and the Ki-67 proliferation index. Results: There was no statistically significant difference between the 5 groups with regard to Bcl-2 staining (p > 0.05). However, Bcl-2 expression in TAM-associated polyps was higher (86%) than in the postmenopausal control group (80%). Positive Ki-67 was highest in the endometrial adenocarcinoma specimens, followed by the atypical complex endometrial hyperplasia group (p < 0.0001). Compared to these 2 groups, Ki-67 expression was lower in TAM-associated polyps, but Ki-67 indexes were significantly higher in the TAM-associated group than in the control group (p < 0.0001). Conclusion: Since TAM-associated polyps tend to have higher proliferation indexes and Ki-67 ratios than control groups, we suggest that they are likely to have a higher malignant potential.Öğe The first case of de novo B-cell prolymphocytic leukemia with central nervous system involvement: Description of an unreported complication(Pergamon-Elsevier Science Ltd, 2009) Pamuk, Guelsuem Emel; Puyan, Fulya Oz; Unlu, Ercument; Ozturk, Erman; Demir, Muzaffer[Abstract Not Available]Öğe Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model(Elsevier Sci Ltd, 2011) Benlier, Erol; Eskiocak, Sevgi; Puyan, Fulya Oz; Kandulu, Huseyin; Unal, Yasin; Top, Husamettin; Aygit, Ahmet CemalBackground: Electrical injuries induce progressive tissue loss caused by free oxygen radicals released from neutrophil aggregates. Fucoidin, a potent inhibitor of L-selectin function, reduces the aggregation of neutrophils. The aim of this study was to evaluate the effect of fucoidin on tissue damage in rat electrical burn injury model. Methods: Forty-two male Wistar albino rats (250-300 g) were divided into 3 groups (Group A (n = 6), control group without electrical burn injury; Groups B (n = 18) and C (n = 18), electrical burn injury groups without and with fucoidin therapy, respectively). Three separate analyses were performed at different time points on 6 out of 18 mice from Group B and C at each time point. Biochemistry (myeloperoxidase and malondialdehyde levels) and histopathology (number of neutrophils) of the skin and muscle biopsies at 1st hour; tissue edema (ratio of wet weight/dry weight of extremities) at 24th hour; and necrotic areas at 7th day after electrical injury were evaluated. The electrical burn was induced by exposing rats to 220 V AC between their left upper extremity and right lower extremity for 10 s. Fucoidin was administered as 25 mg/kg intravenous bolus injection at 15 mm after electrical burn injury. Results: Myeloperoxidase and malondialdehyde levels, number of neutrophils, tissue edema, and necrotic area were significantly less in fucoidin-applied rats than the group without fucoidin therapy. Conclusions: Fucoidin inhibits tissue damage induced by electrical burn injury in rats by reducing necrotic area, edema and number of neutrophils. (C) 2011 Elsevier Ltd and ISBI. All rights reserved.Öğe Granulomatous hypophysitis: presentation and MRI appearance(Churchill Livingstone, 2006) Unlu, Ercument; Puyan, Fulya Oz; Bilgi, Selcuk; Hamamcioglu, M. KemalGranulomatous hypophysitis (GrHy) is a relatively rare inflammatory disease compared with lymphocytic hypophysitis. Only a few cases with magnetic resonance imaging (MRI) findings have been reported to date. We describe the MRI findings for two patients with GrHy with unusual histories and clinical outcomes. (c) 2006 Elsevier Ltd. All rights reserved.Öğe Histopathological and immune alterations in autopsied kidneys(Saudi Med J, 2014) Usta, Ufuk; Tastekin, Ebru; Isler, Erhan; Kutlu, Ali K.; Puyan, Fulya OzObjectives: To collect data on all detectable histologic and immune alterations from the kidneys of 55 autopsy cases. Methods: This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that were performed in 2011 and 2012. All kidney samples were evaluated under a light microscope and fresh tissue samples were used for immunofluorescence microscopy. Immunohistochemically kappa (kappa) and lambda (lambda) antibodies were applied to the tissue sections. The glomerular, tubulo-interstitial, and vascular alterations, as well as immune depositions were noted. Results: The microscopic morphology was close to normal histology in only 23 cases, and 23 cases had glomerular alterations. Nineteen cases had at least one immune deposition. There was immunoglobulin A deposition in 13 cases, and 9 cases showed positivity for both. and. immunohistochemically, and there was no clonal positivity. Conclusion: The most striking outcome of our study is the high rate of immune depositions. There was also a significant number of glomerular and non-glomerular renal alterations.Öğe Incidental Detection of Subcutaneous Myopericytoma of Trunk on FDG PET/CT and Bone Scintigraphy for Imaging of Colon Cancer(Lippincott Williams & Wilkins, 2016) Demir, Selin Soyluoglu; Sarikaya, Ali; Aktas, Gul Ege; Puyan, Fulya Oz[Abstract Not Available]Öğe Indomethacin-induced gastric damage in rats and the protective effect of donkey milk(Termedia Publishing House Ltd, 2018) Tastekin, Ebru; Ayvaz, Suleyman; Usta, Ufuk; Aydogdu, Nurettin; Cancilar, Ekrem; Puyan, Fulya OzIntroduction: Indomethacin is an anti-inflammatory drug with clearly known side effects on gastric mucosa. New treatment and side effect prevention methods are being studied. Donkey milk, as a nutritional support, has recently come into the spotlight with its anti-oxidant features, high antibody content and low allergenic properties. In this study, we investigated donkey milk's possible protective effect against acute gastric mucosal damage by indomethacin. Material and methods: Four groups, each composed of 8 rats, were created. Rats in the first and third groups were fed with standard rat chow, while those in the second and fourth groups were additionally fed with 25 mg/kg of donkey milk per day via nasogastric gavage. On the 11th day gastric mucosal damage was induced by oral administration of 30 mg/kg of indomethacin to the rats in groups 3 and 4. Six h later all rats were sacrificed and their stomachs were removed for macroscopic and microscopic evaluation as well as biochemical examination of glutathione (GSH) and malondialdehyde (MDA) levels. Tumor necrosis factor-alpha (TNF-alpha) expression in the gastric mucosa was evaluated immunohistochemically. Results: In the donkey milk-indomethacin group, total area of erosion and degree of linear ulceration were significantly lower than in the standard food-indomethacin group (p < 0.05). Also, GSH levels were increased and MDA levels were decreased significantly in this group. Tumor necrosis factor-alpha expression was more prevalent and stronger in the gastritis group, while lower expression was observed in the donkey milk group. Conclusions: Donkey milk was observed to have significant protective effects against gastric damage induced by indomethacin.Öğe Leiomyosarcoma of the breast - a case report(Aves, 2011) Can, Nuray; Altaner, Semsi; Puyan, Fulya Oz; Peglivanoglu, Zeynep; Kutlu, A. KemalPrimary leiomyosarcomas of the breast are extremely rare tumors. There were approximately thirty patients reported in the literature up to date. Herein, we report a 66-years old female patient who presented with an enlarging mass in her right breast which was diagnosed as primary leiomyosarcoma following previous mixed invasive ductal carcinoma and invasive lobular carcinoma in her left breast. Although primary leiomyosarcomas of the breast are very rare tumors, they should be kept in mind in the differential diagnosis of spindle cell breast tumors including metaplastic carcinoma in patients with prior breast cancer.
