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Öğe Comparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Rats(Hellenic Veterinary Medical Soc, 2020) Cakina, S.; Gulyasar, T.; Ozen, A.; Parlar, S.; Cukur, Z.; Kurkcu, N.; Uzal, C.In this study, we aimed to compare the protective effects of melatonin and amifostine on radiation-induced oxidative stress. Fifty female Wistar rats (3-4 months old, weighing 200 +/- 25 g) were divided into five groups (with ten rats each) and treated as follows: control (Cont), radiotherapy alone (RT), radiotherapy + amifostine (RT+A-MI), radiotherapy + melatonin (RT+MEL), radiotherapy + amifostine + melatonin (RT+AMI+MEL). Rats were irradiated individually with a single dose of 8 Gy and amifostine (200 mg/kg) and melatonin (10 mg/kg) was administered to rats 30 minutes before irradiation. At the end of this follow-up period (72 hours) the rats were sacrificed. Spectrophotometric Analysis has been performed to kidney tissue samples. As a result of statistical comparison between groups after RT, total antioxidant capacity (TAC) decreased, total oxidant status (TOS) and oxidative stress index (OSI) increased, although the statistically significant change was only for OSI (p = 0.030). Addition of AMI or MEL to RT increased TAC and OSI significantly (p = 0.000), but there was no additive effect for TAC and OSI when both drugs were given together (p = 1.000, p = 0.172, respectively). In terms of TOS, statistically significant increasing was only for AMI (p = 0.000). There was protective effect when both drugs were given together against on Radiation-Induced Renal Oxidative Stress.Öğe Investigation of cardiac and pulmonar doses in patients with left sided breast cancer treated by radiotherapy with deep inspiration breath hold technique(Ijrr-Iranian Journal Radiation Res, 2022) Parlar, S.; Var, G.; Cosar, R.; Dogan, M.; Ozguven, Y.; Nurlu, D.; CemUzal, M.Background: Cardiac disease is a documented risk factor in left breast irradiation. In an attempt to reduce cardiac toxicity, different treatment techniques adapted to respiratory cycle phases have been developed. The aim of this study is to investigate the feasibility of the voluntary breath hold technique when irradiating the left breast in selected patients. Material and Methods: The study included 20 patients with left sided breast cancer. For each patient, two computed tomography (CT) scans were acquired, one with the free breathing (FB) technique and one with the voluntary deep inspiration breath hold (DIBH) technique. Treatment plans were created using a field-in-field intensity-modulated radiation therapy technique. A dosimetric comparison was made between the two techniques for the heart, left anterior descending (LAD) coronary artery, ipsilateral lung and contralateral breast. Results: The average of the mean dose of the heart decreased from 7.7 Gy to 5.8 Gy and V-20(Gy) (%) from 12.8% to 8.3% using the DIBH technique (p=0.009, p<0.001). The DIBH technique demonstrated significantly smaller maximum heart distance (2.0 cm vs. 0.9 cm, p < 0.001) and 8.0% reduction in LAD mean dose. Furthermore, D-mean for the ipsilateral lung was reduced from 12.8 Gy to 12.2 Gy and V-20(Gy) (%) from 25.6% to 22.8%. Conclusion: In the treatment plans made using the DIBH technique, a significant reduction in the radiation dose delivered to the heart has been observed. In order to reduce long-term morbidity and mortality risks from cardiovascular disease affecting the survival of patients with left sided breast cancer, irradiation techniques such as the DIBH should be considered, especially for premenopausal patients.Öğe The radioprotective effect of dimethyl sulfoxide in radiation induced acute pulmonary injury: detection by Tc99m-DTPA transalveolar clearance scintigraphy and histopathology(Pergamon-Elsevier Science Ltd, 2009) Denizli, B.; Cosar-Alas, R.; Durmus-Altun, G.; Can, U.; Aktas, C.; Kanter, M.; Parlar, S.[Abstract Not Available]
