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Öğe Application of the 2012 Systemic Lupus International collaborating clinics classification criteria on a multicenter group of Turkish systemic lupus erythematosus patients(Clinical & Exper Rheumatology, 2015) Yavuz, S.; Pamuk, O. N.; Cefle, A.; Yilmaz, N.[Abstract Not Available]Öğe ARE CLINICAL FEATURES IN LOFGREN'S SYNDROME-RELATED ERYTHEMA NODOSUM DIFFERENT FROM IDIOPATHIC ERYTHEMA NODOSUM?(Mattioli 1885, 2012) Donmez, S.; Kisacik, B.; Pamuk, O. N.; Pehlivan, Y.; Aydogdu, E.; Yurekli, O. A.; Onat, A. M.Background and Objectives: We retrospectively evaluated acute sarcoidosis (Lofgren's syndrome) patients diagnosed at 2 centers and compared the clinical features of Lofgren's syndrome (LS) related erythema nodosum (EN) to patients with idiopathic IEN who were diagnosed within the same time frame. Methods: Thirty patients (10 males, 20 females) who were diagnosed with LS and were being followed up for the last 8 years at 2 centers were included. Thirty patients (4 males, 26 females) who were admitted to the rheumatology outpatient clinics for IEN during that time period were taken as controls. The clinical and laboratory features at the initial admission, treatment modalities and response were recorded. Results: Twentyfour (80%) patients with LS related EN had arthritis and/or arthralgia. Fifteen of them had only findings of periarticular ankle inflammation and 4 had polyarthritis. When LS related EN patients were compared to IEN patients, the former group had more arthritis and/or arthralgia (p<0.001), leucocytosis (p=0.02), lymphopenia (p=0.005) and thrombocytosis (p=0.05), and higher ESR (p=0.02). Twentyfive (83.3%) patients with LS related EN were administered oral corticosteroids. In 21 patients, hilar lymphadenopathy disappeared on control chest x-ray and CT; in 3 patients, minimal residual lymph node enlargement was persistent. During a median follow-up of 54 months (range: 10-84 months), none of the LS related EN patients had clinical relapse. Conclusions: Apart from BHL, arthritis and/or arthralgia especially periarticular ankle inflammation is the feature which could be used to differentiate LS related EN from IEN. There is more need for steroids in LS patients and the symptoms quickly resolve with steroids.Öğe The association between type I Interferon Response, complement activation and clinical findings in Systemic Lupus Erythematosus(Clinical & Exper Rheumatology, 2015) Sacar, K.; Pamuk, O. N.; Pamuk, G. E.; Uyanik, M. S.; Donmez, S.[Abstract Not Available]Öğe THE ASSOCIATION BETWEEN TYPE I INTERFERON RESPONSE, COMPLEMENT ACTIVATION AND CLINICAL FINDINGS IN SYSTEMIC LUPUS ERYTHEMATOSUS(Bmj Publishing Group, 2014) Sacar, K.; Pamuk, O. N.; Pamuk, G. E.; Uyanik, M. S.; Donmez, S.[Abstract Not Available]Öğe Atherosclerotic cardiovascular mortality in gouty arthritis and rheumatoid arthritis: is it associated with mean platelet volume and neutrophil/lymphocyte ratio(Wiley-Blackwell, 2015) Pamuk, G.; Maden, M.; Uyanik, M. S.; Pamuk, O. N.[Abstract Not Available]Öğe Autoimmune rheumatic disease associated symptoms in fibromyalgia patients and their influence on anxiety, depression and somatisation: a comparative study(Clinical & Exper Rheumatology, 2012) Donmez, S.; Pamuk, O. N.; Umit, E. G.; Top, M. S.Objective. In this study we evaluated the frequency of autoimmune rheunzatic disease associated major symptoms in fibromyalgia (FM) patients, and the association between their presence and anxiety, depression and somatisation. Methods. Two hundred and thirty-two FM, 78 systemic lupus erythematosus (SLE) patients and 70 healthy controls were included. All subjects were questioned face-to-face for the presence of autoimmune rheumatic disease-associated symptoms and antinuclear antibody (ANA) was determined. All FM patients were questioned for the severity of pain and symptoms of FM by using a visual analogue scale. In addition, all subjects were interrogated for anxiety, depression, somatic symptoms and neuropathic pain by using different validated questionnaires. Results. FM patients had significantly higher frequency of photosensitivity (27.6% vs. 11.4%) and Raynaud phenomenon (22% vs. 10%) when compared to controls (p-values, 0.005 and 0.026). FM patients had significantly lower frequencies of photosensitivity, oral ulcers, xerostomia, and xerophthalmia than SLE patients (all p-values <0.001). ANA positivity was 11.8% in FM patients and 7.1% in healthy controls. ANA-positive and negative FM patients had similar frequencies of autoimmune rheumatic disease symptoms. FM patients with photosensitivity had higher anxiety (p=0.002), somatic symptoms (p=0.015) and neuropathic pain (p=0.03) scores than others. FM patients with Raynaud had higher anxiety (p=0.004), depression (p=0.001), somatic symptom (p<0.001) and neuropathic pain scores than others. Conclusion. The presence of which findings in FM seems to be associated with anxiety, depression, and somatisation rather than ANA positivity and disease severity.Öğe The clinical manifestations and survival of systemic lupus erythematosus patients in Turkey: report from two centers(Sage Publications Ltd, 2013) Pamuk, O. N.; Akbay, F. G.; Doenmez, S.; Yilmaz, N.; Calayir, G. B.; Yavuz, S.Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a variety of clinical features. Survival has become longer as a result of better treatment modalities and better supportive care. There is no information on survival of SLE patients in Turkey. We evaluated clinical features and survival in SLE patients in two rheumatology departments. Methods All SLE patients being followed up by the Department of Rheumatology, Trakya University Medical Faculty, and the Department of Rheumatology, Marmara University Medical Faculty, over the 1996-2012 period were included. Patients were diagnosed with SLE if they fulfilled at least four American College of Rheumatology (ACR) criteria. The clinical and laboratory features, mortality data were obtained from medical charts. Results We had 428 SLE patients, and women (399 patients, 93.2%) far outnumbered men (29 patients, 6.8%). The mean age at the time of SLE diagnosis was 40.312.4 years. The most frequent clinical manifestations were arthritis (76.9%) and photosensitivity (70.1%). Renal disease was present in 32.9% of patients and neurological involvement in 12.9% of patients. After a median follow-up of 60 months, 19 patients died. The most frequent causes of death were ischemic heart disease, chronic renal failure and sepsis. The rate of five-year survival was 96%; 10-year survival, 92%; and 15-year survival, 88.8%. Multivariate Cox analysis showed that serositis at the time of diagnosis, SLE disease activity index (SLEDAI) score 6, and autoimmune hemolytic anemia were independent prognostic factors. Conclusions Data from two centers in Northwestern Turkey show that the mortality rate for SLE is similar to the rate in Western countries.Öğe THE COMPARATIVE ONE-YEAR DRUG SURVIVAL RATE OF TUMOR NECROSIS FACTOR INHIBITORS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND ANKYLOSING SPONDYLITIS; RESULTS FROM TURKBIO REGISTRY(Bmj Publishing Group, 2014) Sari, I.; Kalyoncu, U.; Onat, A. M.; Pamuk, O. N.; Karadag, O.; Kisacik, B.; Senel, S.[Abstract Not Available]Öğe CUTANEOUS SILENT PERIOD IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS WITHOUT NEUROPATHIC SYMPTOMS(Bmj Publishing Group, 2014) Pamuk, O. N.; Tekatas, A.; Tekatas, D. D.; Dogu, Y.; Akdemir, V.[Abstract Not Available]Öğe THE DATABASE FOR SYSTEMIC SCLEROSIS IN TURKEY (SYS-WATCH): ANALYSIS OF PATIENTS WITH ELEVATED PULMONARY ARTERIAL PRESSURES ON ECHOCARDIOGRAPHIC SCREENING FOR PULMONARY HYPERTENSION(Clinical & Exper Rheumatology, 2010) Inanc, M.; Birlik, M.; Onat, A. M.; Ozbalkan, Z.; Yarguku, F.; Kasifoglu, T.; Pamuk, O. N.[Abstract Not Available]Öğe DECREASED DKK-1 LEVELS IN CHRONIC LYMPHOCYTIC LEUKEMIA AT INITIAL DIAGNOSIS MIGHT BE PREDICTIVE OF A HIGHER MORTALITY(Ferrata Storti Foundation, 2014) Pamuk, G. E.; Uyanik, M. S.; Pamuk, O. N.; Tapan, U.[Abstract Not Available]Öğe Detection of sacroillitis and spinal inflammation on colour and duplex doppler sonography in patients with ankylosing spondylitis(B M J Publishing Group, 2006) Pamuk, O. N.; Unlu, E.; Cakir, N.[Abstract Not Available]Öğe Development of primary central nervous system lymphoma in a systemic lupus erythematosus patient after treatment with mycophenolate mofetil and review of the literature(Sage Publications Ltd, 2017) Balci, M. A.; Pamuk, G. E.; Unlu, E.; Usta, U.; Pamuk, O. N.Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma and four cases of PCNSL have previously been described in association with mycophenolate mofetil. We report the fifth case of PCNSL in a patient with lupus nephropathy while on mycophenolate mofetil treatment.Öğe DOSE ESCALATION AND SWITCHING PATTERNS OF ANTI-TNF DRUGS IN RHEUMATOID ARTHRITIS: A RETROSPECTIVE CHART - REVIEW STUDY IN TURKEY(Bmj Publishing Group, 2015) Kalyoncu, U.; Aydin, S. Z.; Dalkilic, E.; Kasifoglu, T.; Kisacik, B.; Pamuk, O. N.; Yilmaz, S.[Abstract Not Available]Öğe Effect of fibromyalgia on bone mineral density in patients with fibromylagia and rheumatoid arthritis(Medknow Publications & Media Pvt Ltd, 2013) Buyukbese, M. A.; Pamuk, O. N.; Yurekli, O. A.; Yesil, N.Objectives: Fibromyalgia (FM) may t cause a decrease in bone mineral density (BMD) because of decreased mobility. The condition is relatively frequent in rheumatoid arthritis (RA) and RA patients with FM have more disability than those without FM. We evaluated the effect of FM on BMD and investigated the effect of FM on BMD in RA patients. Materials and Methods: We included age-matched 56 FM, 52 RA patients, and 37 healthy females as controls. Twenty three of all RA subjects met 1990 ACR FM criteria. Patients using the antiresorptive drugs, those on hormone replacement therapy, patients with thyroid or parathyroid dysfunction were excluded. Self-reported pain and fatigue severity, functional items of FM impact questionnaire were questioned in FM and RA patients. In all subjects, BMD of the lumbar spine and femur neck were determined by dual X-ray absorptiometry, and T-scores were recorded. Results: Self-reported pain and fatigue scores in FM subjects were significantly higher than in RA patients (P<0.001). The mean lumbar spine and femur neck BMD and their T-scores in RA patients were significantly lower than in FM and control groups (P values<0.01). There was no difference in BMD between FM subjects and the control group. BMD in RA patients with and without FM were similar (P>0.05). There was a significant negative correlation between self-reported pain score and lumbar spine BMD in FM subjects (r=-0.41, P=0.006). Conclusions: In spite of functional disability, FM does not cause a decrease in BMD. The presence of FM in RA patients does not result in a change in BMD.Öğe Effect of pregnancy on the course of immune thrombocytopenia: a retrospective multicenter study(Wiley-Blackwell, 2016) Pamuk, G. E.; Maden, M.; Pamuk, O. N.; Sincan, G.; Yildizhan, E.; Turak, Ermis E.; Cagliyan, Akgun G.[Abstract Not Available]Öğe THE EPIDEMIOLOGICAL AND CLINICAL FEATURES OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS FOLLOWED UP AT A SINGLE CENTER IN NORTHWESTERN TURKEY(Bmj Publishing Group, 2015) Pamuk, O. N.; Balci, M. A.; Donmez, S.; Pamuk, G. E.[Abstract Not Available]Öğe EPIDEMIOLOGY AND OUTCOME OF ADULT-ONSET STILL'S DISEASE IN NORTHWESTERN THRACE REGION IN TURKEY(Bmj Publishing Group, 2015) Balci, M. A.; Pamuk, O. N.; Pamuk, G. E.; Uzundere, F. K.; Donmez, S.[Abstract Not Available]Öğe Epidemiology and outcome of adult-onset Still's disease in the Northwestern Thrace region in Turkey(Clinical & Exper Rheumatology, 2015) Balci, M. A.; Pamuk, O. N.; Pamuk, G. E.; Uzundere, F. K.; Donmez, S.Objective Adult-onset Still's disease (AOSD) is a rare disease that is classified among the multifactorial autoinflammatory disorders. It is characterised by fever, arthritis and, a typical salmon-coloured rash, and is accompanied by fever at nights. Currently, there is limited data on the prevalence of AOSD. Methods Patients diagnosed with AOSD at the Department of Rheumatology of Trakya University Medical Faculty, between 2003 to 2014 were reviewed retrospectively. Patients' clinical features, laboratory measurements, demographics, treatments, follow-up durations, disease courses, outcomes and complications were evaluated. Results Our study included 42 patients with AOSD of whom, 32 (76.2%) were females and 10 (23.8%) were males (female to male ratio: 3.2). Over the course of the study, the annual incidence of AOSD was 0.62/100,000; and the overall prevalence was 6.77/100,000. The most common findings were fever (97.6%), arthralgia (95.2%), arthritis (76.2%), rash (73.8%) and sore throat (40.5%). Conclusion In our hospital-based study on AOSD which is a disease with very limited epidemiological data, the frequency of AOSD was found to be significantly higher than in other series. Female gender was more common in our series; and polycyclic pattern was more common in patients with longer follow-ups.Öğe EPIDEMIOLOGY AND OUTCOME OF DERMATOMYOSITIS IN NORTHWESTERN THRACE REGION IN TURKEY(Bmj Publishing Group, 2016) Balci, M. A.; Saritas, F.; Donmez, S.; Pamuk, O. N.[Abstract Not Available]
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