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    Chronic idiopathic demyelinating polyneuropathy (CIDP) associated with Kaposi's sarcoma
    (Springer, 2006) Celik, Yahya; Turgut, Nilda; Turgut, Burhan; Pamuk, Guelsuem E.; Demir, Muzaffer
    [Abstract Not Available]
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    Dorsal sural nerve conduction study in vitamin B12 deficiency with megaloblastic anemia
    (Blackwell Publishing, 2006) Turgut, Burhan; Turgut, Nilda; Akpinar, Seval; Balci, Kemal; Pamuk, Guelsuem E.; Tekguenduez, Emre; Demir, Muzaffer
    Peripheral neuropathy is frequently observed in B-12 deficiency. In spite of this, there is little knowledge about peripheral neuropathy in B-12 deficiency because the severity of clinical involvement of the central nervous system clearly outweighs signs and symptoms due to peripheral nervous system involvement. We primarily investigated peripheral neuropathy with dorsal sural conduction study, which is a new method for detection of early peripheral neuropathy, in B-12 deficiency with megaloblastic anemia. Conventional nerve conduction studies and tibial sensory-evoked potential (SEP) recording were also performed. Twenty-eight B-12-deficient patients (15 male, 13 female, mean age 65.8 years) with megaloblastic anemia and 18 age- and sex-matched controls were included in the study. Although dorsal sural sensory nerve action potentials (SNAPs) were not recorded in 15 (54%) of 28 patients, only 9 (32%) of them were found to have polyneuropathy by conventional conduction studies. Furthermore, patients with dorsal sural SNAP had mean lower amplitude, mean longer latency, and slower velocity response when compared with controls. Twenty patients (71%) were diagnosed as having myelopathy by the combination of tibial SEP and neurological findings. Two patients whose dorsal sural SNAPs were not recorded had normal tibial SEP responses; therefore, these patients were considered to have isolated peripheral neuropathy. As a result, we conclude that dorsal sural nerve conduction study is a reliable method for detection of early peripheral neuropathy in B-12 deficiency.
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    Testicular Plasmacytoma: Case Report
    (Ortadogu Ad Pres & Publ Co, 2010) Tekgunduz, Emre; Ozturk, Erman; Pamuk, Guelsuem E.; Turgut, Burhan; Puyan, Fulya Oe.; Demir, Muzaffer
    Testicular plasmacytomas are rare tumors presenting in most cases with painless testicular swelling. Testicular involvement may occur as a first manifestation of plasma cell disorder or following diagnosis of systemic plasma cell myeloma. We report a case of a 49-year-old man who was found to have IgG-lambda type multiple myeloma and spinal cord compression at Th 7-9 level. After spinal radiotherapy, he was treated with VAD chemotherapy. just before the second cycle of VAD he admitted with left testicular swelling. Surgical orchiectomy of his left testis was performed. Histological and immunohistochemical studies of surgical material established massive interstitial plasma cell infiltration with strong anti-IgG and anti-lambda antisera staining. Soon after the surgery he died of worsening renal failure and progressive myeloma. We present here a fatal case with an aggressive form of plasma cell myeloma with widespread bone disease along with extramedullary involvement of testis.