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Öğe THE ASSOCIATION BETWEEN TYPE I INTERFERON RESPONSE, COMPLEMENT ACTIVATION AND CLINICAL FINDINGS IN SYSTEMIC LUPUS ERYTHEMATOSUS(Bmj Publishing Group, 2014) Sacar, K.; Pamuk, O. N.; Pamuk, G. E.; Uyanik, M. S.; Donmez, S.[Abstract Not Available]Öğe The association between type I Interferon Response, complement activation and clinical findings in Systemic Lupus Erythematosus(Clinical & Exper Rheumatology, 2015) Sacar, K.; Pamuk, O. N.; Pamuk, G. E.; Uyanik, M. S.; Donmez, S.[Abstract Not Available]Öğe DECREASED DKK-1 LEVELS IN CHRONIC LYMPHOCYTIC LEUKEMIA AT INITIAL DIAGNOSIS MIGHT BE PREDICTIVE OF A HIGHER MORTALITY(Ferrata Storti Foundation, 2014) Pamuk, G. E.; Uyanik, M. S.; Pamuk, O. N.; Tapan, U.[Abstract Not Available]Öğe Development of primary central nervous system lymphoma in a systemic lupus erythematosus patient after treatment with mycophenolate mofetil and review of the literature(Sage Publications Ltd, 2017) Balci, M. A.; Pamuk, G. E.; Unlu, E.; Usta, U.; Pamuk, O. N.Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma and four cases of PCNSL have previously been described in association with mycophenolate mofetil. We report the fifth case of PCNSL in a patient with lupus nephropathy while on mycophenolate mofetil treatment.Öğe DOES ANTI-TNF THERAPY CAUSE ANY CHANGE IN PLATELET ACTIVATION IN ANKYLOSING SPONDYLITIS PATIENTS?(Ferrata Storti Foundation, 2009) Pamuk, G. E.; Pamuk, Oe N.; Orum, H.; Turgut, B.; Demir, M.[Abstract Not Available]Öğe Effect of pregnancy on the course of immune thrombocytopenia: a retrospective multicenter study(Wiley-Blackwell, 2016) Pamuk, G. E.; Maden, M.; Pamuk, O. N.; Sincan, G.; Yildizhan, E.; Turak, Ermis E.; Cagliyan, Akgun G.[Abstract Not Available]Öğe The effect of the ratio between angiogenic and antiangiogenic factors on patients' survival in advanced nonsmall cell lung cancer(Elsevier Science Inc, 2009) Demir, V; Demir, M.; Cicin, I; Pamuk, G. E.; Ozturk, E.; Tekgunduz, E.; Caglar, T.[Abstract Not Available]Öğe THE EPIDEMIOLOGICAL AND CLINICAL FEATURES OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS FOLLOWED UP AT A SINGLE CENTER IN NORTHWESTERN TURKEY(Bmj Publishing Group, 2015) Pamuk, O. N.; Balci, M. A.; Donmez, S.; Pamuk, G. E.[Abstract Not Available]Öğe EPIDEMIOLOGY AND OUTCOME OF ADULT-ONSET STILL'S DISEASE IN NORTHWESTERN THRACE REGION IN TURKEY(Bmj Publishing Group, 2015) Balci, M. A.; Pamuk, O. N.; Pamuk, G. E.; Uzundere, F. K.; Donmez, S.[Abstract Not Available]Öğe Epidemiology and outcome of adult-onset Still's disease in the Northwestern Thrace region in Turkey(Clinical & Exper Rheumatology, 2015) Balci, M. A.; Pamuk, O. N.; Pamuk, G. E.; Uzundere, F. K.; Donmez, S.Objective Adult-onset Still's disease (AOSD) is a rare disease that is classified among the multifactorial autoinflammatory disorders. It is characterised by fever, arthritis and, a typical salmon-coloured rash, and is accompanied by fever at nights. Currently, there is limited data on the prevalence of AOSD. Methods Patients diagnosed with AOSD at the Department of Rheumatology of Trakya University Medical Faculty, between 2003 to 2014 were reviewed retrospectively. Patients' clinical features, laboratory measurements, demographics, treatments, follow-up durations, disease courses, outcomes and complications were evaluated. Results Our study included 42 patients with AOSD of whom, 32 (76.2%) were females and 10 (23.8%) were males (female to male ratio: 3.2). Over the course of the study, the annual incidence of AOSD was 0.62/100,000; and the overall prevalence was 6.77/100,000. The most common findings were fever (97.6%), arthralgia (95.2%), arthritis (76.2%), rash (73.8%) and sore throat (40.5%). Conclusion In our hospital-based study on AOSD which is a disease with very limited epidemiological data, the frequency of AOSD was found to be significantly higher than in other series. Female gender was more common in our series; and polycyclic pattern was more common in patients with longer follow-ups.Öğe Giant cell arteritis and polymyalgia rheumatica in northwestern Turkey: Clinical features and epidemiological data(Clinical & Exper Rheumatology, 2009) Pamuk, O. N.; Donmez, S.; Karahan, B.; Pamuk, G. E.; Cakir, N.Objective. In this study, we evaluated clinical and epidemiologic features of our giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) patients. Methods. Me retrospectively recorded down the general features of patients with GCA and PMR diagnosed at our center within the last 6 years. The incidence rates per 100000 aged. >= 50 were calculated. In addition, we reported the frequencies of GCA/PMR in our previous epidemiologic study. Results. Nineteen patients were diagnosed with GCA (10F, 9M) and 53 with isolated PMR (39F 14M). The annual incidence for GCA in subjects >= 50 years old was 1.13/100000, and for PMR it was 3.15/100000. The incidence of GCA and PMR in females were, respectively, 1.14/100000 and 4.48/100000. In males, the incidences of GCA and PMR were, respectively, calculated as 1.1/100000 and 1.72/100000. In our population-based study, the prevalences of GCA and PMR (>= 50 ages) were estimated as 20/100000. Fourteen (73.7%) GCA patients had symptoms of PMR. Two patients had developed unilateral and one patient bilateral permanent visual loss. Initial ESR was lower than 40 mm/hr in one GCA patient (5.3%) and in 6 PMR patients (11.3%). The median duration of follow-up(l) was 16 months in GCA; and 8 months in PMR patients. One patient with PMR and another patient with GCA had lung cancer. One PMR patient had myelodysplastic syndrome. During follow-up, 4 patients with GCA died. Conclusions. Me detected a lower frequency GCA/PMR in our center in northwestern Turkey than in Scandinavian and southern European countries.Öğe Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10.: Correlation with clinical features and outcome(Bmc, 2006) Pamuk, G. E.; Turgut, B.; Demir, M.; Vural, Oe.It was reported that interieukin-10 (IL-10) level increased in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) patients; moreover this was associated with poor prognosis. In addition, it was stated that adiponectin induced the antiinflammatory cytokine IL-10. We evaluated adiponectin and IL-10 levels in NHL and CLL patients. We included newly diagnosed 28 NHL, 23 CLL patients, and 17 healthy subjects. In NHL patients, adiponectin level was higher than in CLL group and controls (p values <0.05). In CLL group, IL-10 level was lower than in NHL, and control groups (p values <0.05). Adiponectin level had a positive correlation with IL-10 level in the NHL patients (r=0.41, p=0.04). In the NHL group, the median survival of patients with high IL-10 levels was shorter (22 months vs. not reached, p=0.03). Increased IL-10 levels helped to predict poor outcome in our NHL patients. High adiponectin levels and a relationship between adiponectin/IL-10 in newly diagnosed NHL patients might suggest a role for both in the immunodysregulation in NHL.Öğe INCREASED LEVELS OF PLATELET-LEUCOCYTE COMPLEXES IN BEHCET'S DISEASE PATIENTS WITH MAJOR VASCULAR INVOLVEMENT(Ferrata Storti Foundation, 2009) Pamuk, G. E.; Pamuk, Oe N.; Orum, H.; Demir, M.; Turgut, B.[Abstract Not Available]Öğe INCREASED OXIDATIVE DNA DAMAGE AND IMPAIRED GENE REPAIRING PATHWAY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS(Bmj Publishing Group, 2016) Donmez, S.; Pamuk, G. E.; Doganlar, O.; Pamuk, O. N.[Abstract Not Available]Öğe INCREASED SERUM TIE-2 LEVEL IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND RELATED FACTORS(Bmj Publishing Group, 2015) Pamuk, O. N.; Pamuk, G. E.; Gedik, M.[Abstract Not Available]Öğe Increased serum Tie-2 Level in Systemic Lupus Erythematosus patients and related factors(Clinical & Exper Rheumatology, 2015) Pamuk, O. N.; Pamuk, G. E.; Gedik, M.[Abstract Not Available]Öğe IS HIGHER IL-21 LEVEL PREDICTIVE OF RELAPSES IN IMMUNE THROMBOCYTOPENIA AND IS IT ASSOCIATED WITH ACTIVATION OF THE COMPLEMENT SYSTEM?(Ferrata Storti Foundation, 2014) Pamuk, G. E.; Sahip, B.; Uyanik, M. S.; Demir, M.; Pamuk, O. N.[Abstract Not Available]Öğe Mean platelet volume as a biomarker of disease activity in polymyalgia rheumatica(Wiley-Blackwell, 2016) Pamuk, G. E.; Maden, M.; Pamuk, O. N.[Abstract Not Available]Öğe mTOR staining in bone marrow and spleen tissues of immune thrombocytopenia patients is associated with shorter relapse-free survival(Wiley-Blackwell, 2016) Pamuk, G. E.; Puyan, Oz F.; Uyanik, M. S.; Tastekin, E.[Abstract Not Available]Öğe The outcome of eltrombopag therapy in immune thrombocytopenia: a multicenter study from Turkey(Wiley-Blackwell, 2016) Pamuk, G. E.; Maden, M.; Sari, H., I; Erkurt, M. A.; Keskinkilic, M.; Cagliyan, Akgun G.; Kaya, A. H.[Abstract Not Available]
