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    Investigation of the effect of MHD slip flow on heat transfer between parallel plates with second-order slip boundary conditions
    (Begell House Inc., 2021) Simsek H.; Ozturk A.
    In this study, the effect of the second-order slip boundary condition flow model on the flow and heat transfer characteristics in the presence of a magnetic field acting normal to the plate surface in the magnetohydrodynamic (MHD) flow between the parallel microplates with constant heat flux is analytically investigated. The flow of incompressible viscous fluid between the fixed parallel microplates with electrical conductivity was assumed to be steady, laminar, hydrodynamic, and thermally fully developed. The energy equation with the viscous dissipation is solved analytically using the second-order slip velocity and temperature jump boundary conditions in the slip flow regime. Theoretical results obtained from the momentum and energy equations show that the magnetic field parameter, Knudsen number, Brinkman number, and the second-order slip flow boundary condition model parameters affect the velocity and temperature distributions considerably. Furthermore, it was found that the second-order slip flow boundary condition is needed to predict the flow characteristics more accurately. © 2021 by Begell House, Inc.
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    A multicenter, retrospective archive study of radiological and clinical features of ALK-positive non-small cell lung cancer patients and crizotinib efficacy
    (2024) Kilickap S.; Ozturk A.; Karadurmus N.; Korkmaz T.; Yumuk P.F.; Cicin I.; Paydas S.
    To evaluate radiological and clinical features in metastatic anaplastic lymphoma kinase+ non-small cell lung cancer patients and crizotinib efficacy in different lines. This national, non-interventional, multicenter, retrospective archive screening study evaluated demographic, clinical, and radiological imaging features, and treatment approaches in patients treated between 2013-2017. Totally 367 patients (54.8% males, median age at diagnosis 54 years) were included. Of them, 45.4% were smokers, and 8.7% had a family history of lung cancer. On radiological findings, 55.9% of the tumors were located peripherally, 7.7% of the patients had cavitary lesions, and 42.9% presented with pleural effusion. Pleural effusion was higher in nonsmokers than in smokers (37.3% vs. 25.3%, P?=?.018). About 47.4% of cases developed distant metastases during treatment, most frequently to the brain (26.2%). Chemotherapy was the first line treatment in 55.0%. Objective response rate was 61.9% (complete response: 7.6%; partial response: 54.2%). The highest complete and partial response rates were observed in patients who received crizotinib as the 2nd line treatment. The median progression-free survival was 14 months (standard error: 1.4, 95% confidence interval: 11.2-16.8 months). Crizotinib treatment lines yielded similar progression-free survival (P?=?.078). The most frequent treatment-related adverse event was fatigue (14.7%). Adrenal gland metastasis was significantly higher in males and smokers, and pleural involvement and effusion were significantly higher in nonsmokers-a novel finding that has not been reported previously. The radiological and histological characteristics were consistent with the literature data, but several differences in clinical characteristics might be related to population characteristics. Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.
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    Unsteady mixed convection over spinning isothermal bodies with blowing and suction [Conference Paper
    (American Society of Mechanical Engineers (ASME), 2000) Ozturk A.; Ece M.C.
    Initial development of the laminar thermal boundary-layer flow over an impulsively started translating and spinning axisymmetrical isothermal body with blowing and suction in the case of mixed convection is investigated. Velocity components and temperature are expanded in series in powers of the square root of time. Leading, first and second order functions are obtained analytically and the third, forth and fifth order functions are determined numerically. Application of the general results to a sphere shows that buoyancy driven aiding and opposing flows help surface suction in retarding and surface blowing in facilitating the onset of flow separation respectively. Surface heat flux is increased near the front stagnation point due to the axial inflow created by the body spin and enhanced by the circulating flow inside the separated region. Surface suction is found to increase the heat transfer while the surface blowing decreases it. Aiding and opposing flows increase the surface heat flux around the front and rear stagnation points respectively. © 2000 by ASME.