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    The first case of de novo B-cell prolymphocytic leukemia with central nervous system involvement: Description of an unreported complication
    (Pergamon-Elsevier Science Ltd, 2009) Pamuk, Guelsuem Emel; Puyan, Fulya Oz; Unlu, Ercument; Ozturk, Erman; Demir, Muzaffer
    [Abstract Not Available]
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    Splenic marginal zone lymphoma with aberrant CD5 expression: Report of a case
    (Springer, 2007) Puyan, Fulya Oz; Usta, Ufuk; Ozdemir, Cigdem; Turgut, Burhan; Ozturk, Erman; Kutlu, A. Kemal
    [Abstract Not Available]
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    Sticky Platelet Syndrome in Patients with Uninduced Venous Thrombosis
    (Galenos Yayincilik, 2013) Tekgunduz, Emre; Demir, Muzaffer; Erikci, Alev Akyol; Akpinar, Seval; Ozturk, Erman; Kirkizlar, Onur
    Objective: Sticky platelet syndrome (SPS) is a common autosomal dominant inherited platelet disorder. SPS is characterized by platelet hyperreactivity and is associated with arterial and venous thrombosis. The aim of this study was to determine the role of SPS in patients with uninduced venous thrombosis. Material and Methods: The study included 28 patients (15 male and 13 female) with uninduced venous thrombosis. SPS was defined according to Mammen's aggregation method, which is described in detail elsewhere. Results: According to the defined ranges for platelet hyperreactivity, 3 (50%) patients, 2 (33%), and 1 (17%) (n =6 [21%]) with a confirmed diagnosis were classified as type II, I, and III SPS, respectively. In 1 patient SPS was the only hereditary abnormality noted. The other 5 patients carried other inherited coagulation defects, in addition to SPS. Conclusion: The present findings indicate that the prevalence of SPS was 21% in the patients with uninduced venous thrombosis. We therefore suggest that SPS should be considered in the differential diagnosis of such cases.
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    Successful treatment of severe gastrointestinal bleeding after chemotherapy in acute myeloblastic leukemia with recombinant activated factor VII Report on one case and review of other uses in acute leukemias
    (Humana Press Inc, 2010) Pamuk, Guelsuem Emel; Tasci, Murat; Ozturk, Erman; Demir, Muzaffer
    Hemorrhage is a frequent complication in patients with acute leukemias as a result of chemotherapy-induced myelosuppression. Gastrointestinal bleeding in thrombocytopenic patients carries a high mortality. Patients are generally managed with red blood cell, platelet suspensions, and fresh frozen plasma; and sometimes with pharmacologic and endoscopic interventions. If these therapeutic measures fail, patients might be treated with hemostatic drugs, one example of which is recombinant activated factor VII (rFVIIa). This drug is recommended for all kinds of bleeding in hemophiliacs with inhibitors; it is also being used for the treatment of bleeding in thrombocytopenia and platelet function disorders. We present our 44-year-old female patient who had gastrointestinal system bleeding after remission induction therapy for acute myeloid leukemia. Thrombocytopenia was refractory to apheresis platelets; and gastrointestinal bleeding could be controlled only after the administration of a single dose (35 mu g/kg, total dose 2.4 mg) of rFVIIa. Our experience indicates that rFVIIa might be a novel treatment alternative in massive bleeding in leukemic patients with thrombocytopenia or platelet function disorders.
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    Testicular Plasmacytoma: Case Report
    (Ortadogu Ad Pres & Publ Co, 2010) Tekgunduz, Emre; Ozturk, Erman; Pamuk, Guelsuem E.; Turgut, Burhan; Puyan, Fulya Oe.; Demir, Muzaffer
    Testicular plasmacytomas are rare tumors presenting in most cases with painless testicular swelling. Testicular involvement may occur as a first manifestation of plasma cell disorder or following diagnosis of systemic plasma cell myeloma. We report a case of a 49-year-old man who was found to have IgG-lambda type multiple myeloma and spinal cord compression at Th 7-9 level. After spinal radiotherapy, he was treated with VAD chemotherapy. just before the second cycle of VAD he admitted with left testicular swelling. Surgical orchiectomy of his left testis was performed. Histological and immunohistochemical studies of surgical material established massive interstitial plasma cell infiltration with strong anti-IgG and anti-lambda antisera staining. Soon after the surgery he died of worsening renal failure and progressive myeloma. We present here a fatal case with an aggressive form of plasma cell myeloma with widespread bone disease along with extramedullary involvement of testis.