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    Inflammatory fibroid polyp
    (Aves Yayincilik, Ibrahim Kara, 2008) Ilgili, Ayseguel; Usta, Ufuk; Ozpuyan, Fulya; Yalcin, Oemer
    Inflammatory fibroid polyp is a rare benign lesion that most frequently originates from the gastric antrum, but can also be seen in any part of the gastrointestinal tract. Differential diagnosis includes gastrointestinal polyps and polypoid stromal tumors due to their polypoid appearance on gross examination, and microscopically, various malignant and benign stromal tumors, primarily gastrointestinal stromal tumors. We presented a 51-year-old female patient who was referred to our center with a diagnosis of adenocarcinoma made after an endoscopic biopsy, but found to have an inflammatory fibroid polyp located in the antrum after distal subtotal gastrectomy.
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    Influence of N-acetylcysteine on renal toxicity of cadmium in rats
    (Springer, 2008) Kaplan, Mustafa; Atakan, Irfan H.; Aydogdu, Nurettin; Aktoz, Tevfik; Ozpuyan, Fulya; Seren, Guelay; Tokuc, Burcu
    The aim of this study was to investigate the ability of N-acetylcysteine (NAC) to prevent cadmium (Cd)-induced renal damage and whether NAC would reverse cadmium damage to the kidney. Fifty adult male rats were divided into five experimental groups: group 1 received tap water for 3 months and 7 days, group 2 received cadmium chloride (CdCl2) for 3 months, group 3 (NAC cotreatment group) received CdCl2 and 0.5% NAC in tap water for 3 months, group 4 received CdCl2 in tap water for 3 months and 3 months later received only tap water for 7 days, and group 5 (NAC posttreatment group) received CdCl2 in tap water for 3 months and 3 months later received 2% NAC in tap water for 7 days. NAC significantly decreased the elevated kidney malondialdehyde levels, as a marker of lipid peroxidation, in both cotreatment and posttreatment modalities. Cotreatment and posttreatment with NAC significantly increased kidney superoxide dismutase enzyme activity and glutathione level but did not change kidney catalase enzyme activity. NAC decreased fractional excretion of sodium in posttreatment group. Neither Cd nor NAC affected the glomerular filtration rate (GFR). Cotreatment and posttreatment with NAC reduced the effects of Cd on proximal tubules. It was found that NAC showed these effects without changing kidney accumulation of cadmium. Exogenously administrated NAC might reduce toxic effects of Cd on the kidney without any reduction in tissue Cd level.
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    An interesting mediastinal cyst case: Benign cystic mesothelioma
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2018) Yanik, Fazli; Karamustafaoglu, Yekta Altemur; Ozpuyan, Fulya; Yoruk, Yener
    Anterior mediastinal, well-defined, ametabolic cystic lesion was detected incidentally in a 69-year-old male patient. Uniportal video-thoracoscopic surgery was performed to the lesion for diagnosis and treatment purposes. Histopathological findings were in accordance with benign cystic mesothelioma. Benign cystic mesothelioma has been defined in the abdomen, particularly among females of reproductive age. Benign cystic mesothelioma originating from mediastinal pleura is very rare entity and was not defined in the literature. To our knowledge, we present this rare and interesting mediastinal cystic lesion for the first time in the literature.
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    Protective effect of L-carnitine versus amifostine against cisplatin-induced nephrotoxicity in rats
    (Humana Press Inc, 2011) Uzunoglu, Sernaz; Karagol, Hakan; Ozpuyan, Fulya; Cosar, Rusen; Cicin, Irfan; Yurutcaloglu, Vuslat; Denizli, Bengu
    We aimed to compare the protective effect of L-carnitine (CAR) and amifostine (AMF) against cisplatin (CDDP)-induced nephrotoxicity through biochemical markers and histopathological evaluation. Fifty-seven Wistar albino male rats were randomly classified into six groups, which were AMF+CDDP (n = 11; 200 mg/kg AMF 30 min prior to 7 mg/kg CDDP), CAR? CDDP (n = 11; 300 mg/kg CAR 30 min prior to 7 mg/kg CDDP), CDDP (n = 11; 1 mL/kg isotonic saline 30 min prior to 7 mg/kg CDDP), AMF (n = 8; 200 mg/kg AMF alone), CAR (n = 8; 300 mg/kg CAR alone), and control (n = 8; 1 mL/kg isotonic saline alone). All drugs were given intra-peritoneally. Five days after medication, animals were killed, and samples of blood and kidney tissues were collected for biochemical and histopathological evaluation. The serum urea level was highest in AMF+CDDP group among CDDP-applied groups without statistical significance (median, range: 88, 56-21 mg/dL; P > 0.05). There was no statistical significance among CDDP-applied groups in terms of creatinine level (P > 0.05). In the AMF+CDDP group, the median glomerular, tubular, and tubulointerstitial inflammatory damage scores were significantly higher than the other CDDP-applied groups (P < 0.001). The difference between CAR? CDDP and CDDP groups was not statistically significant in terms of renal damage scores. AMF? CDDP group had significantly higher median total nephrotoxicity score than all the other groups (P < 0.001). To conclude, AMF or CAR has no protective effect on CDDP-induced nephrotoxicity. Furthermore, our findings suggest that application of AMF before CDDP may enhance CDDP-induced nephrotoxicity histopathologically.