Yazar "Ozlece, Hatice Kose" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • Küçük Resim Yok
    Öğe
    Accumulation of ?-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers
    (Hindawi Ltd, 2017) Solmaz, Volkan; Ozlece, Hatice Kose; Eroglu, Huseyin Avni; Aktug, Huseyin; Erbas, Oytun; Taskiran, Dilek
    Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar accumulation of alpha-synuclein in streptozotocin-(STZ-) induced diabetes model in rats. Methods. Twelve rats were included in the study. Diabetes (p = 6) was induced with a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). Diabetes was verified after 48 h by measuring blood glucose levels. Six rats served as controls. Following 8 weeks, rats were sacrificed for biochemical and immunohistochemical evaluation. Results. Plasma MDA levels were significantly higher in diabetic rats when compared with the control rats (p < 0.01), while plasma GSH levels were lower in the diabetic group than in the control group (p < 0.01). Also, plasma pentraxin-3 levels were statistically higher in diabetic rats than in the control rats (p < 0.01). The analysis of cerebellar alpha-synuclein immunohistochemistry showed a significant increase in alpha-synuclein immunoexpression in the diabetic group compared to the control group (p < 0.01). Conclusion. Due to increased inflammation and oxidative stress in the chronic period of hyperglycemia linked to diabetes, there may be alpha-synuclein accumulation in the cerebellum and the plasma PTX3 levels may be assessed as an important biomarker of this situation.
  • Küçük Resim Yok
    Öğe
    Do you have restless leg syndrome? I understood from your eyes
    (Springer Heidelberg, 2019) Ozlece, Hatice Kose; Solmaz, Volkan; Ozal, Sadik Altan; Celik, Yahya
    Purpose According to many studies in the literature, there is a strong association between restless leg syndrome and dopaminergic dysfunction. Dopamine is also the major catecholamine in the retina and is also a possible transmitter of the amacrine and interplexiform cells. The aim of this study is to investigate the possible association between RLS and retinal thickness. Methods In this study, we included 33 patients who were diagnosed with idiopathic RLS according to the International RLS Study Group criteria and 31 healthy subjects. All the patients and controls underwent routine ophthalmologic examination and had spectral-domain optical coherence tomography (OCT) performed. We compared the retinal thickness of the patients and control subjects. Results In the RLS group, foveal thickness was thinner then controls. Also, only inferior, superior, and temporal quadrant retina nerve fiber layer (RNFL) thickness were significantly thinner in the RLS group. The parafoveal ganglion cell complex (GCC) in the superior temporal, inferior temporal, inferior nasal quadrant, and perifoveal superior nasal thickness was also significantly thinner in the patient group. Pearson correlation analyses showed that there were statistically significant negative correlations between disease duration and macular GCC and RNFL thickness. Negative correlations were also detected between parafoveal superior, temporal, inferior and nasal macular thickness, parafoveal superior nasal, inferior temporal GCC thickness, and perifoveal superior nasal GCC thickness and disease duration. Conclusion According to our results; most retinal layers are thinner in RLS patients, so it can be considered that OCT has a predictive value for progression of RLS.
  • Küçük Resim Yok
    Öğe
    Evaluation of the association between sexual dysfunction and demyelinating plaque location and number in female multiple sclerosis patients
    (Taylor & Francis Ltd, 2018) Solmaz, Volkan; Ozlece, Hatice Kose; Him, Aydin; Gunes, Ayfer; Cordano, Christian; Aksoy, Durdane; Celik, Yahya
    Purpose: To investigate the frequency of sexual dysfunction (SD) in female multiple sclerosis (MS) patients and to explore its association with the location and number of demyelinating lesions. Material and Methods: We evaluated 42 female patients and 41 healthy subjects. All patients underwent neurological examination and 1.5 T brain and full spinal MRI. All subjects completed the female sexual function index (FSFI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Short-Form 36 Quality of Life Scale (SF-36). All participants were also evaluated for serum thyroid stimulating hormone (TSH), T4, estradiol, and total testosterone. Results: No statistically significant differences between the MS and control groups were found for age, body mass index (BMI), serum TSH, T4, E2, and total testosterone level. MS patients had a statistically significantly lower FSFI and SF-36 scores and higher BDI and BAI scores compared with healthy subjects. The location and number of demyelinating lesions were not associated with SD. Conclusion: In our cohort, this difference in SD appears unrelated to the location and number of demyelinating lesions. These findings highlight the importance of the assessment and treatment of psychiatric comorbidities, such as depression and anxiety, in MS patients reporting SD.
  • Küçük Resim Yok
    Öğe
    Neuroprotective effects of octreotide on diabetic neuropathy in rats
    (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017) Solmaz, Volkan; Cinar, Bilge Piri; Yigitturk, Gurkan; Ozlece, Hatice Kose; Eroglu, Huseyin Avni; Tekatas, Aslan; Erbas, Oytun
    The purpose of the present study is to investigate the possible healing effects of octreotide (OCT) on motor performance, electrophysiological and histopathological findings of diabetic neuropathy in a rat model of diabetes mellitus (DM). To induce diabetes, rats were administered a single dose (60 mg/kg) of streptozotocin (STZ). Diabetic rats were treated either with saline (1 ml/kg/day, n = 7) or OCT (0.1 mg/kg/ day, n = 7) for four weeks. Seven rats served as control group and received no treatment. At the end of the study, electromyography (EMG), gross motor function (inclined plate test), general histology and the perineural thickness of sciatic nerve were evaluated. At the end of study, weight loss was significantly lower in OCT treated rats than that of saline treated ones (p < 0.001). Electrophysiologically, compound muscle action potential (CMAP) amplitudes of the saline treated DM group were significantly reduced than those of controls (p < 0.0001). Also, distal latency and CMAP durations were significantly prolonged in saline treated DM group (p < 0.05) compared to control. However, treatment of diabetic rats with OCT significantly counteracted these alterations in EMG. Furthermore, OCT significantly improved the motor performance scores in diabetic rats (p < 0.05). Histomorphometric assessment of the sciatic nerve demonstrated a significant reduction in perineural thickness in OCT treated group compared to saline group. In conclusion, OCT possesses beneficial effects against STZ-induced diabetic neuropathy, which promisingly support the use of OCT as a neuroprotective agent in patients with diabetic neuropathy. (C) 2017 Elsevier Masson SAS. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Response to: The association between retinal thickness variations and restless leg syndrome (RLS)
    (Springer Heidelberg, 2019) Ozlece, Hatice Kose; Solmaz, Volkan; Ozal, Sadik Altan; Celik, Yahya
    [Abstract Not Available]
  • Küçük Resim Yok
    Öğe
    Ultrasonographic and Electrophysiological Evaluation of the Ulnar Nerve in Patients Diagnosed With Carpal Tunnel Syndrome
    (Lippincott Williams & Wilkins, 2016) Ozlece, Hatice Kose; Huseyinoglu, Nergiz; Gok, Mustafa; Ilik, Faik
    Purpose: In this study, we evaluated the ulnar nerve of patients diagnosed with carpal tunnel syndrome (CTS) using electrophysiology and ultrasonography. Methods: The study included 86 patients (136 hands) and 39 controls (78 hands) with normal electrophysiological assessment. According to Bland's classification, patients were divided into group 1 (grades 1-3 CTS) or group 2 (grades 4-6 CTS). The ulnar nerve was evaluated at the wrist using nerve conduction studies and ultrasonography. Results: The sensory velocity was slower in group 2 than in group 1 (P < 0.001), slower in group 2 than in controls (P < 0.001), and slower in group 1 than in controls (P < 0.005). Although the ultrasonography results showed a reduction in the ulnar nerve cross-sectional area in group 1 compared with controls, the difference was not statistically significant. However, the reduction was significant in group 2 compared with group 1 and controls (P < 0.001). Conclusions: Based on our study results, the ulnar nerve is affected electrophysiologically and morphologically in patients with CTS, especially those with advanced-stage CTS.