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    The assessment of nuchal translucency and serum markers for down syndrome screening with ductus venosus Doppler measurements in the first trimester
    (Galenos Yayincilik, 2010) Ozer, Ozlem; Sayin, Cenk N.; Varol, Fusun G.
    Objective: The aim of the study was to improve nuchal translucency (NT) and serum marker Down syndrome (Tri21) screening methods by including fetal ductus venosus (DV) Doppler measurements. Material and Methods: A total of 213 pregnant women were screened consecutively by combining maternal age, fetal NT and maternal serum pregnancy associated plasma protein A (PAPP-A) and free 13-human chorionic gonadotropin (f beta-1-1CG) values at 11-14 weeks of gestation. Also, a DV Doppler analysis was performed for the contribution to the screening for Tri21 and other fetal anomalies or adverse pregnancy outcomes. Results: Twelve fetuses had DV PI measurements above the 95th percentile and two (17%) developed intrauterine growth retardation. DV P1 values negatively correlated with birth weight (p=0.013, r=0.171). Two patients had T 21 among the study group (0.9%) with abnormal biochemical screening results. In these with Tri21, the combined test risk was above the suggested limit (>1/250). PAPP-A was <0.4 MoM in 23, and f beta-HCG was >1.91 MoM in 49 patients. The rates of fake positivity were 10% for PAPP-A and 22% for f beta-EICG. The sensitivity, specificity, positive and negative predictive values of the combined test was l00%,95%, 2011/1) and 100%, respectively. Conclusion: The combined test has high sensitivity and specificity for Tri21 detection. The addition of DV Doppler ultrasound in the first trimester might have the advantage of predicting some adverse pregnancy outcomes. However, in the Turkish population, further studies with larger numbers of patients will be needed to establish the usefulness of DV for the detection of Trill or the prediction of some major cardiac anomalies.
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    Examination of Pandemic Awareness, Death Anxiety, and Spiritual Well-Being in Elderly Individuals
    (Sage Publications Inc, 2022) Ozer, Ozlem; Ozkan, Okan; Buyuksirin, Bilge
    This study aimed to examine the relationships between the variables of pandemic awareness, death anxiety, and spiritual well-being and reveal whether the participants' perceptions of pandemic awareness, death anxiety, and spiritual well-being differed according to various sociodemographic characteristics. The study population is comprised of individuals aged 65 years and over in Edirne, Turkey. The data obtained from 449 people in the study were analyzed using various statistical methods. According to the results of the regression analysis performed in the study, the increase in the participants' pandemic awareness was found to reduce their death anxiety and increase their spiritual well-being statistically. Moreover, the increase in the participants' death anxiety statistically reduced their spiritual well-being.