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Öğe Acute radiation effect in the brain in infant rats: Neurocognitive and histopathological examination(Imprimatur Publications, 2011) Gorker, I.; Yurut-Caloglu, V.; Karadag, H.; Caloglu, M.; Altaner, S.; Cengiz, H.; Ozen, A.Purpose: The aim of the present study was to evaluate the radiation-induced cognitive dysfunction and the radioprotective effect of amifostine (AMI) in the brain of infantile rats. Methods: Thirty 2-week-old rats were randomly assigned into 3 groups of 10 rats each. Group 1 : control (CONT), group 2: radiation alone (RT), and group 3: AMI before radiation (AMI+RT). The rats in the RT and AMI+RT groups were irradiated individually with a single dose of 20 Gy. All animals were evaluated by using the Morris water maze test to evaluate of their cognitive functions. Histopathological analyses of the hippocampus were also carried out after euthanasia. Results: The study showed that the place navigational function and the spatial probe test were not significantly different between the groups. Conclusion: It can be said that it is very important to determine when the radiation-induced brain injury is formed. From a clinical perspective, the patients can be intervened before irreversible functional deficits are formed and may be amenable to treatment.Öğe Can radiation-induced chronic oxidative stress in kidney and liver be prevented by dimethylsulfoxide? Biochemical determination by serum and tissue markers(Imprimatur Publications, 2012) Cosar, R.; Eskiocak, S.; Caloglu, V. Yurut; Ozen, A.; Uzal, C.; Caloglu, M.; Ibis, K.Purpose: To investigate the protective effects of dimethylsulfoxide (DMSO) on chronic oxidative stress in the liver, kidney and serum with biochemical parameters such as malondialdehyde (MDA), advanced oxidation protein product (AOPP), catalase, glutathione (GSH), and free-thiols (F-SW. Methods: Thirty Wistar albino female rats were randomly divided into 3 groups: group [(control, n=10), group H (irradiation-alone group, n=10) and group III (DMSO and irradiation group, n=10). Rats in groups II and III were irradiated with a single dose of 6 Gy to the entire liver and right kidney. Group III received DMSO 4.5 g/kg by intraperitoneal injection 30 min before irradiation. At the end of the 24th week, the rats were sacrificed and their trunk blood, kidney and liver tissues were collected. Results: Group II rats showed increased levels of lipid peroxidation and protein oxidation, with decreased GSH, F-SH and catalase levels in all specimens when compared with group I. Serum and kidney MDA and AOPP levels were significantly lower in group III when compared with group II. However, serum and kidney GSH and F-SH levels were significantly higher in group III when compared with group II. The additive effect on catalase was seen only in the serum. Conclusion: DMSO is a protective agent on chronic oxidative stress in the serum and kidney tissue. No oxidant or antioxidant effect of DMSO in the liver was seen.Öğe Can Radiation-Induced Chronic-Oxidative Stress in Kidney and Liver Be Prevented by Dimethyl Sulfoxide? Biochemical Determination by Serum and Tissue Markers(Elsevier Sci Ltd, 2011) Cosar, R.; Eskiocak, S.; Yurut-Caloglu, V.; Ozen, A.; Uzal, C.; Caloglu, M.; Ibis, K.[Abstract Not Available]Öğe Comparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Rats(Hellenic Veterinary Medical Soc, 2020) Cakina, S.; Gulyasar, T.; Ozen, A.; Parlar, S.; Cukur, Z.; Kurkcu, N.; Uzal, C.In this study, we aimed to compare the protective effects of melatonin and amifostine on radiation-induced oxidative stress. Fifty female Wistar rats (3-4 months old, weighing 200 +/- 25 g) were divided into five groups (with ten rats each) and treated as follows: control (Cont), radiotherapy alone (RT), radiotherapy + amifostine (RT+A-MI), radiotherapy + melatonin (RT+MEL), radiotherapy + amifostine + melatonin (RT+AMI+MEL). Rats were irradiated individually with a single dose of 8 Gy and amifostine (200 mg/kg) and melatonin (10 mg/kg) was administered to rats 30 minutes before irradiation. At the end of this follow-up period (72 hours) the rats were sacrificed. Spectrophotometric Analysis has been performed to kidney tissue samples. As a result of statistical comparison between groups after RT, total antioxidant capacity (TAC) decreased, total oxidant status (TOS) and oxidative stress index (OSI) increased, although the statistically significant change was only for OSI (p = 0.030). Addition of AMI or MEL to RT increased TAC and OSI significantly (p = 0.000), but there was no additive effect for TAC and OSI when both drugs were given together (p = 1.000, p = 0.172, respectively). In terms of TOS, statistically significant increasing was only for AMI (p = 0.000). There was protective effect when both drugs were given together against on Radiation-Induced Renal Oxidative Stress.Öğe CYCLIN D1 (A870G) GENE POLYMORPHISM IN LUNG CANCER(Elsevier Ireland Ltd, 2011) Cakina, S.; Gulyasar, T.; Sipahi, T.; Ozen, A.; Kocak, Z.[Abstract Not Available]Öğe The effect of gender differences on radiation induced acute lung toxicity by using XRCC1, XRCC3 and HHR2L gene panel(Elsevier Ireland Ltd, 2015) Ozen, A.; Cakina, S.; Turkkan, G.; Cosar, R.; Sipahi, T.; Kocak, Z.; Uzal, C.[Abstract Not Available]Öğe EVALUATION OF BRCA 1-2 GENE MUTATIONS IN PATIENTS WITH TRIPLE NEGATIVE AND ER(-), PR(-), HER-2(+) BREAST CANCER(Elsevier Ireland Ltd, 2011) Uzal, M. C.; Sener, S.; Ozen, A.; Cakina, S.; Sipahi, T.; Cosar, R.; Gulyasar, T.[Abstract Not Available]Öğe THE PROTECTIVE EFFECT OF AMIFOSTINE ON RADIATION-INDUCED PROCTITIS: SYSTEMIC VERSUS TOPICAL APPLICATION(Elsevier Ireland Ltd, 2011) Uzal, M. C.; Sezer, A.; Usta, U.; Sut, N.; Ozen, A.; Yagci, M. A.[Abstract Not Available]Öğe PROTECTIVE ROLE OF CARNITINE AGAINST RADIATION-INDUCED KIDNEY DAMAGE IN INFANT RATS: SCINTIGRAPHIC AND HISTOPATHOLOGIC EVALUATION(Elsevier Ireland Ltd, 2011) Rusen, C.; Altun, G. Durmus; Puyan, F. Oz; Saynak, M.; Ibis, K.; Ozen, A.; Bayir-Angin, G.[Abstract Not Available]Öğe RADIATION-INDUCED CHRONIC-OXIDATIVE RENAL DAMAGE CAN BE REDUCED BY AMIFOSTINE(Elsevier Ireland Ltd, 2011) Rusen, C.; Yurut-Caloglu, V.; Eskiocak, S.; Ozen, A.; Ibis, K.; Turan, N.; Denizli, B.[Abstract Not Available]Öğe Sudden death: A case report of hepatocellular carcinoma with tumor thrombus extending into the right atrium(Zerbinis Medical Publ, 2007) Saynak, M.; Ozen, A.; Kocak, Z.; Cosar-Alas, R.; Uzal, C.[Abstract Not Available]Öğe What is the effect of ethnic status in early stage endometrial cancer? A retrospective analysis of 223 patients(Elsevier Ireland Ltd, 2014) Ozen, A.; Moore, D. T.; Varia, M. A.; Jones, E. L.[Abstract Not Available]
