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Öğe Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities(Walter De Gruyter Gmbh, 2021) Goger, Gamze; Allak, Muhammed; Sen, Ali; Goger, Fatih; Tekin, Mehmet; Ozek, GulmiraPhytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and beta-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and alpha-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 mu g/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 mu g/mL, whereas, CAD showed the best inhibition of a-glucosidase with an IC50 value of 396.40 mu g/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 mu g/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.Öğe Chemical Compositions of Achillea sivasica: Different Plant Part Volatiles, Enantiomers and Fatty Acids(Acg Publications, 2018) Ozek, Gulmira; Tekin, Mehmet; Haliloglu, Yesim; Baser, Kemal Husnu Can; Ozek, Temel[Abstract Not Available]Öğe Composition and potential of Tanacetum haussknechtii Bornm. Grierson as antioxidant and inhibitor of acetylcholinesterase, tyrosinase, and -amylase enzymes(Taylor & Francis Inc, 2018) Yur, Suleyman; Tekin, Mehmet; Goger, Fatih; Baser, Kemal H. C.; Ozek, Temel; Ozek, GulmiraThe phytochemical composition of essential oils and extracts of Tanacetum haussknechtii were investigated with GC-FID-MS and LC-MS/MS techniques and evaluated against oxidation, acetylcholinesterase, tyrosinase, and -amylase enzymes. The major volatile constituents of T. haussknectii were found to be - and -pinene, and borneol. Caffeoylquinic acid derivatives and flavonoids were detected in the aqueous, alcohol, and ethyl acetate extracts. In DPPH assay, the methanol extracts exhibited the highest activity. TEAC assay resulted with superiority of all methanol and the capitula ethyl acetate extract. In -carotene bleaching assay, linoleic acid was the best protected by the ethyl acetate extract of flower. The flower oil inhibited higher acetylcholinesterase activity than the remaining extracts. The flower ethyl acetate extract was found as the most effective inhibitor of -amylase. The herb and the leaf+stem water extracts possess highest inhibitory effect on tyrosinase.Öğe SCREENING OF Achillea coarctata Poir. AND Achillea setacea Waldst. & Kit. (Asteraceae) FOR THEIR VOLATILE AND FATTY ACIDS COMPOSITIONS, AND ANTIMICROBIAL ACTIVITIES(Trakya Univ Balkan Yerlesesi Enstituler Binasi, 2023) Goger, Gamze; Cevik, Esma; Varnali, Alisan; Yaylaci, Omer Koray; Uma, Medine Munevver; Ozek, GulmiraThe main aim of this study is antimicrobial screening of the n-hexane, ethyl acetate and aqueous extracts obtained from aerial parts of Achillea setacea Waldst. & Kit. and Achillea coarctata Poir. against the bacterial strains Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 14028 and the yeast Candida albicans ATCC 6633 by the microdilution method. In addition, the effect of the aqueous extract of A. coarctata combined with fluconazole againts C. albicans ATCC 6633, C. parapsilosis ATCC 22019, C. tropicalis ATCC 750 and C. glabrata ATCC 90030 was tested with the checkerboard method. The chemical components of the volatiles and fatty acid methyl esters were identified using the Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS) techniques. The main components of the volatile oil were found to be 1,8-cineole (16.1%) and beta-pinene (14.5%) for A. setacea and camphor (35.4%) and borneol (12.9%) for A. coarctata. The ethyl acetate extracts of A. setacea (MIC=156.25 mu g/mL) and A. coarctata (MIC=312.5 mu g/mL) were found more active against the tested Candida Berkh. species. The combination of aqueous extract of A. coarctata with fluconazole showed additive effect for the tested Candida species with FIC values within the range of 0.53-0.625 mu g/mL.Öğe Volatiles and fatty acid analyzes of Tripleurospermum decipiens (Fisch & C. A. Mey) Bornm and investigation of the extracts for antimicrobial and enzyme inhibitory activities(Marmara Univ, 2021) Goger, Gamze; Yavas, Irem; Yur, Suleyman; Kose, Yavuz Bulent; Ozek, GulmiraIn this study, the volatiles were obtained from aerial parts of Tripleurospermum decipiens (Fisch & C.A.Mey) Bornm with microsteam distillation - solid phase microextraction (MSD-SMPE) technique. The fatty acids from T. decipiens were obtained by using the microextraction method with subsequent transesterification with boron trifluoride reagent. The chemical compositions of the volatiles and fatty acid methyl esters was analyzed by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC / MS) techniques. n-Hexane (TDH) and methanol (TDM) extracts of T. decipiens were investigated for acetylcholineterase (AChE), alpha-amylase enzyme inhibitions and antimicrobial activities. In vitro inhibition of AChE was monitored by using Ellman's chromogenic agent, and antidiabetic effects of the extracts were spectrophometrically evaluated by inhibition of porcine pancreatic alpha-amylase enzyme. Antimicrobial activities of the extracts were evaluated against Salmonella enterica ATCC 14028, Bacillus subtilis subsp spizizeni ATCC 6633, B. subtilis ATCC 19654, Staphylococcus aureus ATCC 6538, Klebsiella aerogenes ATCC 13048, Candida parapsilosis ATCC 22019 by microdilution method. In vitro.-amylase enzyme inhibitory activity was observed for methanol extract (55.6%) at 10 mg/mL. The highest AChE inhibition was recorded for n-hexane extract (58.8%) at concentration (10 mg/mL). The extracts were found to be effective against B. subtilis ATCC 19654, B. subtilis subsp spizizeni ATCC 6633, S. aureus ATCC 6538 and C. parapsilosis ATCC 22019.
