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    Correlation of myocardial performance index assessed by different echocardiographic methods in patients with acute myocard infarction receiving different reperfusion treatment
    (Edizioni Minerva Medica, 2013) Pirhan, O.; Ozcelik, F.; Demir, B.; Karakus, G.; Caglar, I. M.; Tureli, H. Oktay; Degirmencioglu, A.
    Aim. Myocardial performance index (MPI) is a well known prognostic parameter in acute myocardial infarction (AMI) patients, which has been used to assess global cardiac functions. In this study, we aimed to evaluate the corelation between the MPI levels obtained by PW doppler and Tissue doppler ultrasonography with reperfusion in AMI patients. Methods. Fifty-four consecutive acute ST elevatation myocardial infarction patients, 26 treated with primary percutaneous coronary intervention (PCI) and 28 with thrombolytic therapy (IT); and 15 consecutive healthy controls were included in the study. MPI levels were measured with pulsed-wave (PW) doppler and tissue Doppler ultrasonography in all patients. The isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT) and ejection time (El) values used to measure MPI levels were determined. Corelation between the time intervals obtained with both methods were evaluated. MPI variations were evaluated in patients treated with PCI and TT. A significant corelation was observed in MPI levels obtained with PW doppler and tissue doppler ultrasonography (P<0.001) as well as between IRT, ICT and ET values (for all parameters; P<0.001). No significant corelation was observed between the MPI levels obtained with PW doppler and tissue doppler ultrasonography in patients treated with primary PTCA and IT (P=0.128, P=0.991, respectively). A significant corelation was observed between the MPI values obtained by PW doppler and tissue doppler ultrasonography with reperfusion interval (P=0.002, P<0.001, respectively). Conclusion. As a result, tissue Doppler ultrasonography may be used as an alternative to PW doppler to evaluate MPI, which is a well known prognostic factor in AMI. No relation has been observed between MPI values in early,phases of AMI with reperfusion pattern, while a connection has been observed between MPI and reperfusion interval.
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    Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies
    (Sage Publications Ltd, 2015) Barutcu, A.; Aksu, F.; Ozcelik, F.; Barutcu, C. A. E.; Umit, G. E.; Pamuk, O. N.; Altun, A.
    The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n=50) and control group (n = 30). They were categorized into four subgroups: anticardiolipin antibodies (aCL) (+) (n = 14) and aCL (-) (n = 36); systemic lupus erythematosus disease activity index (SLEDAI) >= 6 (n = 15) and SLEDAI < 6 (n = 35); disease period >= 5 years (n = 21) and disease period < 5 years (n = 29); major organ involvement (+) (n = 19), major organ involvement (-) (n = 31). The ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity (E/E') for the study group was found to be higher than the control (p < 0.01). Systolic septal motion velocity (Ssm) was lower in the study group compared with the control (p < 0.01). Left atrium (LA) dimension was greater in the study group than the control (p < 0.01). Ssm was found to be lower in the aCL (+) patients compared with the control and aCL (-) groups (p < 0.01, p < 0.05, respectively). LA dimension was greater in the aCL (+) and (-) groups compared with the control, (p < 0.01, p < 0.05, respectively) and aCL groups compared with each other (p < 0.05). The E/E' ratio for the aCL (+) and (-) groups was found to be greater than the control (p < 0.05). In the study, both the Ssm and the late diastolic septal velocity (sA') was found to be lower in the SLEDAI >= 6 group compared with SLEDAI < 6 group, (p < 0.001, p < 0.05, respectively). LA dimension was statistically greater in the SLEDAI >= 6 group compared with the SLEDAI < 6 group (p < 0.001). E' and early diastolic septal velocity (sE') were statistically lower in the disease period > 5 years group compared with the disease period < 5 years group (p < 0.01, p < 0.05, respectively). Carrying out regular scans with TTE image of SLE patients is important in order to identify early cardiac involvement during monitoring and treatment. Identifying early cardiac involvement in SLE may lead to a reduction in mortality and morbidity rates.
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    A retrospective study of angiographically determined anomalous coronary arteries in 12,844 subjects in Thrace region of Turkey
    (Lithographia, 2012) Sivri, N.; Aktoz, M.; Yalta, K.; Ozcelik, F.; Altun, A.
    Background: Congenital anomalies of the coronary arteries are rarely encountered in patients undergoing cardiac catheterization. In patients undergoing coronary angioplasty or cardiac surgery, angiographic recognition of coronary anomalies is important for the proper management of these patients. Method: We retrospectively reviewed the records of 12,844 patients who had previously undergone coronary angiography in the catheterization laboratory of Trakya University Cardiology Department over the past 14 years. We tried to investigate the presence of a variety of coronary anomalies in these patients to determine the prevalence of various types of anomalies and their anatomic variation in a selected population of the European part of Turkey. The potential association between coronary atherosclerosis and congenital coronary anomalies was also investigated. Results: Among these patients, 95 patients were found to have major coronary anomalies that predominantly comprised anomalous aortic origin of coronary arteries. Among the major anomalies, anomalous aortic origin of the left circumflex (LCX) artery from the right sinus of Valsalva or right coronary artery (RCA) was found to be the the most prevalent (46 out of 95 patients) outnumbering the second most common anomaly that was anomalous aortic origin of the RCA (32 out of 95 patients). In the present study, the incidence of major coronary arterial anomaly was found to be 0.74 %. However, only about one third of the patients (31 out of 95, 32.6%) with major anomaly had significant coronary atherosclerotic lesions among whom nine were found to involve the LCX artery with a posterior course. Conclusion: The incidence of congenital coronary anomalies in a selected population of the European part of Turkey is similar to those of other populations. Congenital coronary anomalies generally present as isolated anomalies and are not associated with an increased risk of coronary atherosclerosis in this series. Cardiologists and surgeons should be familiar with these entities for the proper management of patients undergoing cardiac surgery or coronary angioplasty. Hippokratia 2012; 16 (3): 2246-249