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In vitro effects of prostaglandin E1, prostaglandin I2 and papaverine on internal thoracic artery graft
(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2015) Misirlioglu, Ganime; Huseyin, Serhat; Yuksel, Volkan; Guclu, Orkut; Karadag, Hakan; Canbaz, Suat; Ege, Turan
Background: This study aims to investigate the effects of prostaglandin E1, prostaglandin I2, and papaverine on internal thoracic artery grafts which are used during coronary artery bypass graft operations. Methods: Ten patients (9 males, 1 female; mean age 53.7 years; range 46 to 68 years) who were operated in our clinic between March 2013 and September 2013 were enrolled in the study. Dose-dependent effects of prostaglandin E1 and prostaglandin I2 on internal thoracic artery at a concentration interval of 10(-9) M-10(-2.5) M were observed. Results: While prostaglandin I2 had stronger relaxation response than prostaglandin E1 on internal thoracic artery graft, papaverine had the strongest relaxation response. Conclusion: Prostaglandin E1 and prostaglandin I2, which are used in the treatment of many aterosclerotic cardiovascular and peripheral artery diseases, may prevent vasoconstriction in internal thoracic artery grafts. Further clinical studies are required regarding decreasing perioperative mortality and morbidity by increasing graft patency.