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Öğe Abdominal pillow for the sparing of small bowel in four-field conventional pelvic radiotherapy(I R O G Canada, Inc, 2008) Saynak, A.; Kucucuk, S.; Aslay, I.From 2003 through 2004, 88 patients with gynecological cancer were referred to Istanbul University Oncology Institute for pelvic radiation therapy. All patients underwent small bowel evaluation within the pelvic radiotherapy field in both the supine and prone positions with and without an abdominal pillow. The small bowel area included in radiation fields and intestinal movement were compared on PA films. All patients were treated by using the abdominal pillow. The median external beam pelvic radiation dose of 5040cGy (range. 3220-5400cGy) was administered. The mean distance of upward displacement of small bowel in the prone position on abdominal pillow compared with in the prone position alone and in the Supine position was 3.6 cm (range, 0-14 cm) and 4.7 cm (range. 0-14 cm). Using the abdominal pillow, the mean small bowel area was reduced by 45% and 55% compared to the prone position alone and the supine position, respectively (p = 0.0001). In patients who had pelvic surgery intestinal movement was significantly reduced. The incidence of G1, G2 and G3 acute radiation toxicity was 18%. 36% and 3%, respectively. This Study demonstrates that the small intestines can be displaced out of the radiation field by an abdominal pillow in the prone position. Also, this noninvasive technique provides for reduction Of acute gastrointestinal morbidity.Öğe Outcome in carcinoma of the uterus with papillary serous and clear cell histology: A Turkish Oncology Group Study(Amer Soc Clinical Oncology, 2008) Yumuk, P. F.; Kucucuk, S.; Atasoy, B. M.; Aydin, A.; Cicin, I.; Yildiz, F.; Atkovar, G.[Abstract Not Available]Öğe The role of postoperative radiotherapy in node negative breast cancer patients with pT3-T4 disease(Elsevier Sci Ltd, 2007) Aksu, G.; Kucucuk, S.; Fayda, M.; Saynak, M.; Baskaya, S.; Saip, P.; Ozturk, N.Aims: To evaluate the role of postmastectomy radiotherapy (PMRT) in patients with pT3-T4N0M0 breast cancer. Methods: 156 patients with T3-T4N0M0 breast cancer were retrospectively analyzed. Results: Locoregional recurrences were seen in 17 of 156 patients with a median time for development of 27 months (5.7-248.7 months). Two of 9 patients who were not treated with post-operative radiation therapy had locoregional recurrence as compared with 16 of 147 patients receiving radiotherapy. In multivariate analysis, presence of locoregional recurrence was the only significant prognostic factor for overall survival (18% vs. 86%, p < 0.001, RR = 9.05). The patients with a median number of dissected lymph nodes >= 10 had a significantly better locoregional disease free survival rate as compared with patients with dissected lymph nodes < 10 (90% vs. 78%, p = 0.04). Chest wall recurrences were clearly higher in patients without chest wall RT since 5 of 49 patients without RT had recurrences in the chest wall region while only 4 of 107 who received chest wall RT had recurrence. However receiving RT to peripherical lymphatic regions had no additional effect on reducing recurrences in these regions (5% vs. 4%). Conclusions: Due to the lack of phase III randomized trials directly addressing the role of postmastectomy radiotherapy in these stages, our series suggest that postmastectomy radiotherapy to the ipsilateral chest wall is recommended for patients with PT3N0 and T4N0 breast cancer. The need for irradiating axillary or supraclavicular region shall be neglected in patients who undergo sufficient axillary sampling. (c) 2006 Elsevier Ltd. All rights reserved.
