Yazar "Kekecoglu, Meral" seçeneğine göre listele

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    Induction of Micronuclei in Bone Marrow Cells of Mice Exposed to Acetamiprid
    (Springer, 2013) Rasgele, Pinar Goc; Muranli, Fulya Dilek Gokalp; Kekecoglu, Meral
    [Abstract Not Available]
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    INDUCTION OF MICRONUCLEI IN MICE BONE MARROW CELLS BY COBALT AND COPPER CHLORIDES
    (Polska Akad Nauk, Polish Acad Sciences, Inst Environ Eng Pas, 2013) Rasgele, Pinar Goc; Kekecoglu, Meral; Muranli, Fulya Dilek Gokalp
    The aim of our research was to investigate the genotoxic effects of cobalt chloride and copper chloride in mouse bone marrow cells using the micronucleus (MN) assay. The three different concentrations of cobalt chloride (11.2, 22.5 and 45 mg kg(-1)) and copper chloride (1.17, 2.35 and 4.70 mg kg(-1)) were injected intraperitoneally to mice for 24 and 48 hours. It was observed that both of these heavy metals induced a significant increase in frequency of micronucleated polychromatic erythrocytes (MNPCE) at different concentrations in mice for 24 and 48 hours when compared with the control. Furthermore, the significant reduction for the polychromatic erythrocyte/normochromatic erythrocyte (PCE/NCE) ratio which is indicative of bone marrow cytotoxicity was observed in bone marrow cells which were treated with copper chloride at all concentrations for 24 and 48 hours. No reduction of the PCE/NCE ratio was observed both 24 and 48 hours after all the doses of cobalt chloride tested as compared to the negative control. These results lead us to the conclusion that copper chloride may have genotoxic and cytotoxic properties due to induction in the frequency of MN and a reduction in PCE/NCE ratio in bone marrow cells of mice, whereas cobalt chloride induced only genotoxic effect in mice bone marrow.
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    Investigation of genotoxic effects of rhododendron honey using three mammalian bioassays in vivo
    (Taylor & Francis Ltd, 2022) Rasgele, Pinar Goc; Gokalp, Fulya Dilek; Kaya, Salih Tunc; Kekecoglu, Meral; Acar, Merve Kambur
    Rhododendron honey (RH) is obtained from the rhododendron plants are grown in many regions around the world, causes poisoning in humans due to the grayanotoxin (GTX) compound in its structure. It is used by the public as a therapeutic for some diseases. It was aimed to study the genotoxic and cytotoxic effects of RH in mouse bone-marrow and sperm cells by using three mammalian bioassays. 25, 50 and 75 mg kg(-1) concentrations of RH given to male mice via gavage for 24 and 48 h treatment periods and its active ingredient Grayanatoxin (GTX-III) 0.01 mg kg(-1) by i.p. injection. Chromosome aberrations (CA), polychromatic erythrocytes (PCE)/normochromatic erythrocytes (NCE), micronucleated polychromatic erythrocytes (MNPCE) and sperm abnormalities were investigated. The results demonstrated that all the tested concentrations of RH significantly induced total abnormal cell frequency including chromosomal breaks for two time periods. In the MN assay, 75 mg kg(-1) RH and 0.01 mg kg(-1) GTX-III significantly increased % MNPCE and significantly reduced PCE/NCE ratios after 24 and 48 h treatments on mice demonstrating potential genotoxic and cytotoxic effect. Although there was a concentration-related increase in the percentage of total sperm abnormalities, this increase was not statistically significant compared to control. As a result, microscopic genotoxicity and cytotoxicity marker tests showed that RH and its active ingredient GTX-III have potential genotoxic and cytotoxic effect on mice bone marrow cells. It is understood that RH that is used to treat some diseases by public, should be handled carefully and used in a controlled manner.
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    POTENTIAL GENOTOXICITY OF ACETAMIPRID AND PROPINEB SINGLY OR IN COMBINATION IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES BY USING MN ASSAY
    (Parlar Scientific Publications (P S P), 2015) Muranli, Fulya Dilek Gokalp; Rasgele, Pinar Goc; Kekecoglu, Meral; Kanev, Martin; Ozdemir, Kezban
    Acetamiprid, a neonicotinoid insecticide, and Propineb, a dithicarbamate fungicide, are used in agriculture singly or in combination with other pesticides. The aim of the study is to investigate the single and combined genotoxic effect two pesticides on cultured human lymphocytes by using the Micronucleus (MN) assay. The lymphocytes were treated with three different concentrations of pesticides singly and in combination (a mix), Acetamiprid (0.625, 1.25, 2.5 mu g mL(-1)) Propineb (12.5, 25, 50 mu g mL(-1)) and Acetamiprid+Propineb (0.625+12.5, 1.25+25, 2.5+50 mu g mL(-1)), for 24 and 48 hours. MN frequency significantly increased at a 48-hour exposure period when the lymphocytes were exposed to the combined pesticides. The data demonstrated that these pesticides may have a synergistic effect and may have potential genotoxic activity in cultured human lymphocytes. Also, it was shown that when they are combined and exposed to lymphocytes these pesticides have a cytotoxic effect.