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    Different responses of apoptotic, inflammatory and heat shock protein gene expression to a single bout of high-intensity interval exercise between physically active and inactive men
    (Canadian Science Publishing, 2021) Vardar, S. A.; Doganlar, Z. B.; Kaya, O.; Tayfur, P.; Sut, N.; Doganlar, O.
    High mechanical load of muscles may induce muscular apoptosis on the one hand and adaptation to exercise on the other. This study aimed to explore whether changes of circulatory levels of inflammation, apoptosis and heat shock proteins (HSPs) messenger RNA (mRNA) following single bout of high-intensity interval exercise (HIIE) differs between physically active (PA) and inactive (PI) men. Nine PA and 9 PI (peak oxygen consumption: 2.6 +/- 0.4 vs. 2.0 +/- 0.2 L.min(-1)) healthy men (age: 28.7 +/- 6.3 vs. 30.2 +/- 4.5 years and body mass index: 2.6 +/- 2.1 vs. 23.3 +/- 2.8 kg.m(-2)) performed HIIE, comprising 4 repeats of a Wingate test (load: 0.050 kg.kg(-1) body weight). Blood samples were collected before exercise, 5 min after HIIE, and 24 h after HIIE for measuring mRNA of inflammation markers interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha), apoptosis markers including Bcl-2, Bax, and HSP27, HSP60, HSP70, HSP90 using quantitative real-time PCR analysis. Post-HIIE IL-6, TNF alpha and HSP60 were higher in the PI than the PA group 5 min after exercise (p = 0.003, effect size (ES) = 1.59; p = 0.007, ES = 1.59 and p = 0.027, ES = 1.10 respectively). HSP70 acutely increased only in the PA group (p = 0.024, ES = 1.20). The increase in Bcl-2 (p = 0.047, ES = 1.08) and Bax (p = 0.024, ES = 1.20) levels were higher in the PI group 5 min after HIIE. The present study indicated that the response of inflammatory, apoptosis and HSP gene expressions to HIIE in blood of healthy male volunteers strongly depends on their level of regular physical activity. Novelty: Blood IL-6 and HSP60 mRNA levels following high intensity exercise may indicate metabolic stress. Increased blood HSP70 mRNA in physically active men may show an alternative apoptosis suppression pathway.
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    The Effect of Platelet-Rich Plasma in Inactive Form on the Burn Zone of Stasis in Rats
    (Wiley, 2019) Orhan, E.; Gunduz, O.; Kaya, O.; Metin, M. S.; Tarladacalisir, Y. T.
    [Abstract Not Available]
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    The effects of Tarantula cubensis extract on renal ischemia/reperfusion injury in the rats
    (Wiley-Blackwell, 2014) Aydogdu, N.; Tastekin, E.; Cukur, Z.; Poyraz, M. D.; Yavuz, O. Y.; Kaya, O.
    [Abstract Not Available]