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Öğe 99mTc-dextran scintigraphy to detect disease activity in patients with rheumatoid arthritis(Lippincott Williams & Wilkins, 2004) Kaya, M; Tuna, H; Firat, MF; Tuna, F; Seren, G; Yigitbasi, ÖNAim To test the applicability of Tc-99m-dextran joint scintigraphy in the assessment of disease activity in patients with rheumatoid arthritis (RA), and to compare it with the clinical disease activity scores and laboratory parameters. Methods Twenty-seven patients with RA were investigated using Tc-99m-dextran joint scintigraphy. The images were evaluated semi-quantitatively and the regional uptakes of the radiopharmaceutical were calculated for the knee, wrist and ankle joints. The clinical and laboratory parameters were collected and fully analysed. An articular Ritchie index (a tender joint score), the number of swollen joints (Sw), the number of tender joints, the morning stiffness h, the total Ritchie articular index (R), the visual analogue scale (VAS) and the Disease Activity Score (DAS) were determined for all patients. Results Compared with controls, patients with RA had significantly higher regional Tc-99m-dextran uptake in the knee, wrist and ankle joints (P=0.001). The regional 99mTc-dextran uptake showed no correlation with the patient's age, gender, duration of disease, number of swollen joints (Sw), number of tender joints, morning stiffness (h), VAS, total Ritchie articular index and DAS, or any laboratory parameters. There was a significant correlation between the regional Tc-99m-dextran uptake for individual joints and the articular Ritchie index of the right and left wrist (r=0.42, P=0.03; r=0.45, P=0.02), right and left knee (r=0.66, P<0.0001; r=0.80, P<0.0001) and right and left ankle (r=0.47, P=0.014; r=0.76, P<0.0001), respectively. Conclusions This study demonstrates that 99mTc-dextran scintigraphy is a sensitive method to detect active joint inflammation and could be useful in the management of patients with RA. (C) 2004 Lippincott Williams Wilkins.Öğe Alveolar epithelial permeability in patients with primary spontaneous pneumothorax as determined by Tc-99m DTPA aerosol scintigraphy(Springer, 2004) Tabakoglu, E; Kaya, M; Kutucu, Y; Özdemir, LPurpose: Primary spontaneous pneumothorax (PSP) occurs subsequent to a disruption in the continuity of visceral pleura and escape of air into the pleural space. The cause of PSP is most often the rupture of subpleural blebs or bullae. It is usually difficult to detect evidence of pulmonary pathology. The purposes of the present study were (1) to investigate the changes of pulmonary alveolar epithelial permeability in patients with PSP as determined by Tc-99m DTPA aerosol lung scintigraphy, (2) to assess whether or not some differences exist between apical and basal parts of the lungs, and (3) to determine the relationship between the clearance rate of Tc-99m DTPA and the PFT results, the recurrence rate of PSP, and the percentage of pneumothorax in affected lung. Material and Methods: Thirteen PSP patients (two females, 11 males; mean age 32.5 +/- 11.8 years) with normal chest X-ray were studied. Thirteen healthy non-smoking volunteers (1 female, 12 males; mean age, 35.8 +/- 10 years) were selected as a control group. Tc-99m DTPA aerosol lung scintigraphy and PFT were performed in all patients and controls. Clearance rates (%/min) of Tc-99m DTPA aerosol in right and left lung field, and apical and basal parts of each lung were calculated from dynamic images for 15 min. Results: There was no significant difference (p > 0.05) between patients and controls, or between apical and basal parts of each lung. No correlation was found between the clearance rate of Tc-99m DTPA and PFT results, the recurrence rate of PSP, or the percentage of pneumothorax. Conclusion: This study demonstrates that pulmonary epithelial permeability is not altered in PSP patients; the clearance rate of Tc-99m DTPA shows no difference between apical and basal parts of each lung.Öğe Bone metastasis from primary splenic angiosarcoma to the sacrum demonstrated by Tc-99m-labeled red blood cell and Tc-99m MDP bone scintigraphy(Lippincott Williams & Wilkins, 2001) Çermik, TF; Yüksel, M; Demir, M; Özyilmaz, F; Kaya, M; Vural, Ö; Berkarda, S[Abstract Not Available]Öğe Bone mineral metabolism changes in epileptic children receiving valproic acid(Wiley, 2004) Öner, N; Kaya, M; Karasalihoglu, S; Karaca, H; Çeltik, C; Tütüncüler, FObjective: The aim of this study was to evaluate bone mineral density (BMD) in epileptic children receiving valproic acid (VPA) and to determine differences between osteopenic and non-osteopenic children. Methods: Thirty-three epileptic children, receiving VPA for at least 6 months, were compared with 33 healthy children for BMD. BMD was measured by dual-energy X-ray absorptiometry at lumbar vertebrae, femoral neck and greater trochanter. Serum calcium, phosphorus, alkaline phosphates, osteocalcin and VPA levels were also determined. Results: Patient's osteocalcin levels were significantly higher (P = 0.02) and femur and trochanter BMD values were significantly lower (P = 0.04 and P = 0.03, respectively). Duration of VPA therapy was significantly longer and doses of VPA were significantly higher in seven osteopenic patients compared with 26 non-osteopenic patients. Osteopenic patients (4.6 +/- 2.4 years) were younger than non-osteopenic patients (7.8 +/- 3.2 years) (P = 0.01). Conclusion: Long-term and high dose VPA therapy may cause osteopenia, primarily in younger epileptic children. These patients should be followed closely by BMD measurements.Öğe Brain SPECT findings in Wernicke's encephalopathy(Springer-Verlag Italia Srl, 2004) Çelik, Y; Kaya, MWernicke's encephalopathy, a neurologic disease caused by thiamine deficiency, is observed chiefly in chronic alcoholics. We performed magnetic resonance imaging and single-photon emission computed tomography (SPECT) in an alcoholic patient who had developed Wernicke's encephalopathy. Although cranial MRI detected no pathology, brain SPECT revealed bilateral frontal and frontoparietal hypoperfusion as well as right basal ganglia hypoperfusion.Öğe Brain SPECT study in the children with ataxic and choreoathetoid cerebral palsy(Springer Verlag, 1999) Kaya, M; Sarikaya, A; Karasalihoglu, S; Altun-Durmus, G; Üstün, F; Berkarda, S[Abstract Not Available]Öğe The bronchoalveolar epithelial permeability in house painters as determined by Tc-99m DTPA aerosol scintigraphy(Springer, 2003) Kaya, M; Salan, A; Tabakoglu, E; Aydogdu, N; Berkarda, SPurpose: Isocyanates are highly reactive chemicals used in a number of industries including paints. Therefore, house painters are known to be at risk for occupational exposure to isocyanates. Our objectives in this study were: (1) to investigate the possible effects of isocyanate exposition on the bronchoalveolar epithelial permeability in house painters by using Tc-99m DTPA radioaerosol lung scintigraphy; (2) to assess whether or not some differences exist between asthmatic and non-asthmatic house painters, and (3) to determine the relationship between Tc-99m DTPA radioaerosol lung scintigraphy and the spirometric measurements, and the work duration of house painters. Materials and Methods: Ten non-smoking house painters (28.8 +/- 8.8 yrs) and ten healthy volunteers underwent Tc-99m DTPA radioaerosol lung scintigraphy. Following inhalation of radiotracer through a nebulizer for 5 minutes, dynamic scintigrams (1 frame/min, up to 10 min) were taken from both lungs. ROI's were drawn over the both lung area, and time-activity curves were obtained, from which the half-time (T-1/2) of Tc-99m DTPA clearance was calculated. Spirometric lung function test was measured in all house painters. Results: Mean T1/2 values (min +/- SD) were 93.74 +/- 32.79 for house painters, and 90.96 +/- 40.02 for control subjects. There was no significant difference in T1/2 values of Tc-99m DTPA clearance between house painters and controls, and between asthmatic and non-asthmatic house painters as well. No correlation was observed between Tin values of Tc-99m DTPA clearance and spirometric measurements. In house painters, there was a positive correlation between T1/2 values of Tc-99m DTPA clearance and work duration (r = 0.73, p = 0.016). Conclusions: Our findings indicate that in house painters, occupational exposure to isocyanates has no effect on bronchoalveolar epithelial permeability, and the rate of Tc-99m DTPA clearance shows no difference between asthmatic and non-asthmatic house painters. The positive correlation between the rate of Tc-99m DTPA clearance and work duration needs to be confirmed in larger cohorts.Öğe Comparison between semiquantitative interictal Tc-99m HMPAO SPECT and clinical parameters in children with partial seizures(Elsevier Science Bv, 1999) Sarikaya, A; Kaya, M; Karasalihoglu, S; Alemdar, A; Altun, G; Berkarda, SThe aim of the present study was to correlate between clinical parameters (age, age of onset, frequency and durationof seizures) and semiquantitative interictal SPECT parameters in children with partial seizures. We obtained 30 patients who had hypoperfusion in interictal SPECT, retrospectively. All patients underwent a detailed clinical examination, electroencephalography (EEG) investigation and brain computerized tomography (CT) and/or magnetic resonance imaging (MRI). Single photon emission computerized tomography (SPECT) studies were evaluated visually and by calculating semiquantitative parameters (the degree (asymmetry index, Al) and extent (number of ROI) of hypoperfusion). Visual analysis detected ipsilateral hypoperfusion in 23 (76%) patients with a unilateral focus and contralateral hypoperfusion in seven patients. We found an inverse correlation between the age at onset of seizure (r = -0.40, P = 0.025), frequency of seizures(but positive correlation; r = 0.77, P = 0.000) and AI. Number of ROIs showed a moderate correlation with the frequency of seizures (r = 0.67, P = 0.000), while correlation of the age at onset of seizures was not significant. This study per-formed in pediatric patients also suggested that either SPECT parameters may be used for correlating with clinical parameters. (C) 1999 Elsevier Science B.V. All rights reserved.Öğe Comparison with clearance of Tc-99m DTPA aerosol, and CO diffusing capacity, and lung function test in house painters(Springer-Verlag, 2001) Kaya, M; Salan, A; Tabakoglu, E; Aydogdu, N; Yüksel, M; Salihoglu, YS; Yigitbas, ON[Abstract Not Available]Öğe Detection of tracheoesophageal fistula caused by ingestion of a caustic substance by esophageal scintigraphy(Lippincott Williams & Wilkins, 2005) Kaya, M; Inan, M; Bedel, DA 4-year-old boy was referred for scintigraphic evaluation of esophageal transit 24 hours after he had ingested sodium hydroxide. After oral administration of Tc-99m sulfur colloid, scintigraphy showed marked and prolonged retention of the radioactive bolus in the middle and lower thirds of the esophagus. Three weeks after ingestion of the caustic substance, repeat scintigraphy was requested to evaluate esophageal transit and gastric-emptying. In this presentation, a tracheoesophageal fistula was a consequence of sodium hydroxide ingestion and was identified with radionuclide scintigraphy before there was clinical and radiologic detection.Öğe The evaluation of bone mineral density in epileptic children receiving valproic acid(Springer-Verlag, 2001) Kaya, M; Karasalihoglu, S; Öner, N; Carman, H; Üstün, F; Çeltik, C[Abstract Not Available]Öğe Extensive bone metastases in a patient with prostatic adenocarcinoma and normal serum prostate-specific antigen and prostatic acid phosphatase(Lippincott Williams & Wilkins, 2001) Yuksel, M; Çermik, TF; Kaya, M; Salan, A; Ustun, F; Salihoglu, YS; Yigitbasi, ÖN[Abstract Not Available]Öğe The incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991-2003(Springer, 2005) Ustun, F; Yuksel, M; Durmus-Altun, G; Kaya, M; Çermik, TF; Sarikaya, A; Berkarda, SObjective: The purpose of this retrospective study was to evaluate the incidence of recurrence and the success of radioiodine treatment (RIT) in the Trakya region of Turkey, an area with mild iodine deficiency, and to compare the effect of dose regimen selection (fixed (FD) or calculated dose (CD)) on treatment success. Material and Methods: The study sample included 148 patients (40 male, median age 50) treated with radioiodine between the years 1991-2003. Patients were categorized into three diagnostic groups: Graves' disease (GD) (n = 65), solitary toxic adenoma (TA) (n = 29), and toxic multinodular hyperthyroidism (TMH) (n = 54), and each divided into two subgroups according to treatment method; the first group was treated with a FD of 370 MBq (10 mCi), and the second with CD. Results: The largest group was GD (44%), followed by TMH (36%). Median duration of follow-up was 28 months (range 6-147). FD was given to 52.7% of all patients and CD was given to 47.3%. There was a partial difference in the dose regimen between all groups, but did not reach statistically significant levels (FD vs. CD: 65%-35%; 38%-62%; 46%-54%; GD, TA, TMH respectively, p > 0.05). Total cure rate in FD and CD was 46 (59%) and 37 (52.9%), respectively. The rates of hypothyroidism for GD, TA, and TMH groups were 28 (43.1%), 6 (20.7%) and 16 (29.6%), respectively. The incidence of hypothyroidism did not vary significantly between any groups (p > 0.05). At the end of the follow-up period, a total of 104 patients (70.3%) were treated successfully. There was no significant difference in the cure rate between any groups (p > 0.05). Conclusions: The treatment success in all groups and subgroups did not differ significantly between FD and CD. Our lower cure rate than in previous studies may be related to iodine deficiency. Higher doses of radioiodine may be required to increase final treatment success in endemic goiter areas. If this true, dosimetry and calculated dose regimen would be required in all groups of patients instead of an FD concept. However, our findings should be verified in larger series of patients, with longer follow-up period, and urinary iodine concentration measurements.Öğe Incidental detection of single vertebral osteomyelitis in a patient operated on for parathyroid hyperplasia(Lippincott Williams & Wilkins, 2001) Çermik, TF; Yüksel, M; Yalniz, E; Kaya, M; Ugur, B; Tugrul, A; Berkarda, S[Abstract Not Available]Öğe Increased Tc-99m MIBI uptake in atelectatic lung: A pitfall in scintigraphic evaluation of central bronchogenic carcinoma(Lippincott Williams & Wilkins, 1998) Sarikaya, A; Pekindil, G; Gumuser, FG; Cermik, TF; Erkmen, N; Alemdar, A; Kaya, M[Abstract Not Available]Öğe Isolated bilateral sixth nerve palsy secondary to metastatic carcinoma: a case report with a review of the literature(Elsevier Science Bv, 2003) Kocak, Z; Celik, Y; Uzal, MC; Uygun, K; Kaya, M; Albayram, SIsolated sixth nerve palsies usually occur in the vasculopathic age group and are often associated with diabetes mellitus, hypertension, and atherosclerosis but also occur in the presence of skull base tumors. However, isolated bilateral sixth nerve palsies are an extremely rare complication of skull base lesions due to metastatic neoplasms. A case of a 46-year-old man with metastatic small-cell carcinoma of the lung that developed acute bilateral abducens nerve palsies is presented. Although this appears to be an isolated case, metastasis to the skull base must be included in the differential diagnosis of isolated bilateral sixth nerve palsies. (C) 2003 Elsevier B.V. All rights reserved.Öğe Marchiafava-Bignami disease(Elsevier Science Bv, 2002) Çelik, Y; Kaya, M; Sengün, S; Utku, UMarchiafava-Bignami disease (MBD) associated with chronic alcoholism is a fatal disorder characterized by demyelination of the corpus callosum. It is diagnosed by the imaging of demyelination at the corpus callosum with MRI. This lesion is not only limited to the corpus callosum but also affects the cortico-cortical and cortico-subcortical projections due to disconnection and causes frontal lobe syndromes and dementia. In this article, we presented a case that MBD associated with chronic alcoholism. (C) 2002 Elsevier Science B.V. All rights reserved.Öğe The potential cardioprotective effects of amifostine in irradiated rats(Elsevier Science Inc, 2004) Tokatli, F; Uzal, C; Doganay, L; Kocak, Z; Kaya, M; Ture, M; Kurum, TPurpose: The aim of this study is to determine the cardioprotective efficacy of amifostine. The study consists of researching the relationship between plasma brain natriuretic peptide levels and the electrical and morphologic changes in irradiated rats with or without amifostine. Methods and Materials: Sixty Wistar albino rats were divided into 4 groups, and their hearts were given 15 Gy/fraction with Co-60. In Groups I and II, the rats were killed after 24 hours to detect early effects; in Groups III and IV, the rats were killed 100 days after irradiation to detect late effects. Before irradiation, Groups I and III received 0.9% saline solution, whereas Groups II and IV received amifostine (200 mg/kg). Twenty rats were used as a control group. Results: On the 100th day, mild myocardial degeneration was detected in 5 rats (33%) from Group III (no amifostine). This percentage was statistically different from that of Group IV (treated with amifostine) and the controls (p = 0.042). There was no statistically significant difference between the mean plasma brain natriuretic peptide values of the groups (p > 0.05). There was no significant difference in electrocardiographies between the groups. There was no correlation between continuous variables. Conclusion: In the amifostine group (IV) on the 100th day, there was no myocardial degeneration, suggesting that amifostine has a cardioprotective effect. (C) 2004 Elsevier Inc.Öğe The relationship between 99mTc-HMPAO brain SPECT and the scores of real life rating scale in autistic children(Elsevier Science Bv, 2002) Kaya, M; Karasalihoglu, S; Üstün, F; Gültekin, A; Çermik, TF; Fazlioglu, Y; Türe, MChildhood autism is a developmental disability of unknown origin with probable multiple etiologies. The purpose of this study was to compare the changes of regional cerebral blood flow (rCBF) in autistic and non-autistic controls, and to determine the relationship between rCBF on Tc-99m-hexamethylpropylene amine oxime (HMPAO) brain SPECT and the scores of the Ritvo-Freeman Real Life Rating Scale (RLRS), IQ levels, and age of autistic children. Eighteen autistic children (four girls, 14 boys: mean age: 6.13 +/- 1.99 years) and I I non-autistic controls (five girls, six boys, mean age: 6.5 +/- 3.39 years) were examined using Tc-99m-HMPAO brain SPECT. All the children satisfying DSM-IV criteria for autistic disorder were taken into evaluation, and scored by the Ritvo-Freeman RLRS, IQ levels of these children were determined by Goodenough IQ test. Six cortical regions of interest (ROIs; frontal (F), parietal (P), frontotemporal (FT), temporal (T), temporo-occipital (TO), and occipital (0)) were obtained on transaxial slices for count data acquisition. The ratio of average counts in each ROI to whole-slice Counts for the autistic children was correlated with the scores of Ritvo-Freeman RLRS. Hypoperfusion in rCBF in autistic children compared with the control group were identified in bilateral F. FT, T, and TO regions. We found no relationship between rCBF on Tc-99m-HMPAO brain SPECT and the scores of the Ritvo-Freeman RLRS. There was a relationship between bilateral F regions perfusion on Tc-99m-HMPAO brain SPECT and the age of autistic children. There was also a negative correlation between IQ levels and the scores of sensory responses, social relationship to people, and sensory-motor responses. Our results suggest that Tc-99m-HMPAO brain SPECT is helpful to locate the perfusion abnormalities but no correlation is found between rCBF on Tc-99m-HMPAO brain SPECT and the scores of Ritvo-Freeman RLRS. (C) 2002 Elsevier Science B.V. All rights reserved.Öğe Renal uptake on lung perfusion scintigraphy in a patient with primary pulmonary hypertension(Lippincott Williams & Wilkins, 2005) Kaya, M; Çermik, TF; Tabakoglu, E; Kutucu, YAn 18-year-old woman presented with primary pulmonary hypertension (PPH) and was hospitalized because of hemoptysis and was referred to our department for a differential diagnosis pulmonary thromboembolism. Doppler ultrasonography of the lower extremities was normal. Echocardiography and cardiac catheterization showed right ventricular dilatation and increased pulmonary artery pressure without anatomic (intracardiac) shunt. The mean pulmonary arterial pressure was 110 mm Hg. Tc-99m MAA lung perfusion scans showed nonsegmental patchy defects. Extrapulmonary renal uptake and increased systemic deposition of radiotracer were seen in the MAA scintigraphy. It could be related to a functional intrapulmonary shunt resulting in increasing pressure in the pulmonary artery in PPH.
