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    The IL-33 gene is related to increased susceptibility to systemic sclerosis
    (Springer Heidelberg, 2016) Koca, Suleyman Serdar; Pehlivan, Yavuz; Kara, Murat; Alibaz-Oner, Fatma; Oztuzcu, Serdar; Yilmaz, Neslihan; Cetin, Gozde Yildirim
    Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both in vitro and in vivo settings; moreover, increased level of IL-33 has also been reported in patients with SSc. Therefore, the aim of the present study was to detect the potential association of IL-33 gene polymorphisms on the susceptibility of SSc. A total of 300 SSc patients and 280 healthy controls (HC) were enrolled in this multicentric preliminary candidate gene study. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms (SNPs) of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. There was no significant difference in terms of the allelic distributions and minor allele frequencies of evaluated four IL-33 polymorphisms between the SSc and HC groups (P > 0.05 for all). Moreover, the genotypic distributions of rs1157505, rs11792633 and rs1929992 polymorphisms were not significantly different (P > 0.05 for all). However, CC genotype of rs7044343 SNP was significantly higher in the SSc group compared to the HC group (P = 0.013, OR 1.75, 95 % CI 1.12-2.72). This preliminary candidate gene study demonstrates that rs7044343 polymorphism of IL-33 gene is associated with the susceptibility to the SSc in Turkish population. It may be suggested that IL-33 gene may be a candidate gene to research in SSc.
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    Prevalence of cystic echinococcosis in humans in Erzincan Province
    (2020) Kara, Murat; Damarcı, İsmail; Dabanlıoğlu, Bülent
    Aim: A study was carried out in human patients with suspicion of cystic echinococcosis. Echinococcosis granulosus is a zoonoticdisease that causes cystic echinococcosis in humans and animals. The disease caused by adult or larval stages of tapeworms ofthe genus Echinococcus family.Material and Methods: 1,102 blood samples sent to Erzincan Binali Yıldırım University, Mengücek Gazi Training and ResearchHospital Medical Microbiology Laboratory between January 2011 and December 2018 with suspicion of cystic echinococcosis werecentrifuged at 1500 rpm for 10 minutes. Serum samples were tested immediately by indirect hemagglutination test in order to detectspecific antibodies.Results: 248 of 1,102 blood samples of patients were found to be infected with cystic echinococcosis for the 9-year of period (anaverage annual incidence of 10.48 per 100,000 inhabitants).Conclusion: It is understood that hydatid disease is decreasing in the province, but there is always a risk of increases in cysticechinococcosis for humans.