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Öğe Effects of Nigella sativa and its major constituent, thymoquinone on ethanol induced gastric mucosal damage(Blackwell Publishing, 2006) Kanter, M.; Coskun, O.; Uysal, H.[Abstract Not Available]Öğe Influence of a combination of formic and propionic acids added to wheat- and barley-based diets on the performance and gut histomorphology of broiler chickens(Akademiai Kiado Zrt, 2007) Senkoylu, N.; Samli, H. E.; Kanter, M.; Agma, AylinDay-old male chicks were used to test the effects of a combination of formic and propionic acids (CFP) added to wheat- and barley-based diets on the performance and gut histomorphology of broilers. The CFP, containing formic and propionic acids based on an inorganic phyllo-silicate carrier, was added to starter and grower broiler diets of standard (NRC, 1994) or lower nutrient density (LND) using different levels of wheat and barley. Body weight gain (BWG) and feed conversion ratio (FCR) of broiler chicks were significantly (P < 0.001) improved by CFP supplementation at 21 days of age regardless of nutrient density (ND). However, at 35 days of age CFP addition significantly (P < 0.001) increased BWG and FCR. Proventriculus weight was also significantly affected by the dietary treatments. Ileal viscosity was significantly (P < 0.05) affected by ND which was associated with wheat and barley contents, whereas feed viscosity was significantly (P < 0.05) affected by CFP supplementation. Villus height was significantly (P < 0.05) increased by the CFP supplementation. In the case of villus width, an interaction effect was observed: there was a significant (P < 0.05) decrease in the group fed the standard ND diet, but only a numerical decrease in the group fed the LND diet compared to control group. No significant effect of dietary treatment on the thickness of the lamina muscularis mucosae could be detected.Öğe Protective effects of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats(Academic Press Inc Elsevier Science, 2010) Kanter, M.Testicular torsion causes an enhanced formation of reactive oxygen species, which contributes to the pathophysiology of tissue damage. The aim of this study was to investigate the protective effect of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury. A total of 24 male Wistar albino rats were divided into three groups of 8 animals each: control, I/R, and I/R treated with melatonin. The ischemia period was 5 h and orchiectomy was performed after 5 h of detorsion. Melatonin (10 mg/kg, intraperitoneally [i.p.]) was administrated only once, 40 min prior to detorsion. Spermatogenesis and mean seminiferous tubule diameter (MSTD) were significantly decreased in the I/R groups were compared to the control group. Furthermore, the melatonin treated animals showed an improved histological appearance in the I/R group. Our data indicate a significant reduction in the activity of TUNEL; there was a rise in the expression of proliferating cell nuclear antigen (PCNA) and testosterone in testes tissue of the I/R group treated with melatonin therapy. Electron microscopy of the testes of the rats demonstrated that pretreatment with melatonin was particularly effective in preventing mitochondrial degeneration, dilatation of SER, and enlarged intercellular spaces in both Sertoli and spermatid cells in the I/R treated animals. We believe that further preclinical research into the utility of melatonin may indicate its usefulness as a potential treatment on testes injury after I/R in rats. (C) 2010 Elsevier Inc. All rights reserved.Öğe Protective effects of quercetin on testicular torsion/detorsion-induced ischaemia-reperfusion injury in rats(Wiley-Blackwell, 2010) Aktoz, T.; Kanter, M.; Aktas, C.P>The aim of this study was to investigate the protective effect of quercetin (QE) on testicular torsion/detorsion-induced ischaemia-reperfusion (I/R) injury. A total of 24 male Wistar albino rats were divided into three groups: control, I/R and I/R treated with QE; each group contain eight animals. Testicular torsion was created by rotating the left testis 720 degrees in a clockwise direction. The ischaemia period was 5 h and orchiectomy was performed after 5 h of detorsion. QE (15 mg kg-1, i.p.) was administrated only once, 40 min prior to detorsion. Left orchiectomy was performed in all I/R groups. To date, no histopathological changes on testicular torsion/detorsion-induced I/R injury in rats by QE treatment have been reported. Spermatogenesis and mean seminiferous tubule diameter were significantly decreased in I/R groups were compared with the control group. Furthermore, QE treated animals showed an improved histological appearance in I/R group. Our data indicate a significant reduction in the activity of TUNEL, endothelial nitric oxide synthase and a rise in the expression of testosterone in testes tissue of I/R treated with QE therapy. We believe that further preclinical research into the utility of QE may indicate its usefulness as a potential treatment on testes injury after I/R in rats.Öğe The radioprotective effect of dimethyl sulfoxide in radiation induced acute pulmonary injury: detection by Tc99m-DTPA transalveolar clearance scintigraphy and histopathology(Pergamon-Elsevier Science Ltd, 2009) Denizli, B.; Cosar-Alas, R.; Durmus-Altun, G.; Can, U.; Aktas, C.; Kanter, M.; Parlar, S.[Abstract Not Available]Öğe THE ROLE OF IONIZING RADIATION ON OVULATION RATE AND OOCYTE MORPHOLOGY IN MOUSE(Akademiai Kiado Zrt, 2014) Sapmaz-Metin, Melike; Kanter, M.; Uzal, C.We investigated the effects of ionizing radiation on maturation ability and radiosensitivity of oocytes enclosed in preantral and antral follicles. Balb/c female mice received total body single dose gamma radiation (7.2 Gy) at the diestrous to proestrous transition period. In the first experiment, spontaneously ovulated oocytes were collected from irradiated animals. In the second experiment, irradiated animals were allowed to superovulate to assess the ovarian function. The spontaneous ovulation rate of the follicles exposed at antral stage was significantly lower than the sham-irradiated mice (p < 0.01), and most of the oocytes were found at the metaphase I stage. Oocyte morphology and the ovulation rate of the follicles exposed at preantral stage were similar to the sham-irradiated group. Minimal morphological abnormalities were observed in the oocytes and the polar body as well. The superovulation response of all the irradiated animals was lower than the respective control animals. The superovulation rate was significantly lower in the first ovulation after irradiation (p < 0.01). In conclusion, our findings indicate that total body gamma irradiation, on a basis of estrous cycle stages, leads to ovulation failure in the antral stage while causes abnormal oocyte morphology in the preantral stage follicles in mice.
