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Öğe Analysis of early and last effects concomittant chemoradiotherapy of 24 patients with locally advanced cervical carcinoma (lacc)(Oxford Univ Press, 2004) Tokatli, Fusun; Uygun, Kazim; Ibis, Kamuran; Bayir, Gulden; Denizli, Bengu; Uzal, Cem[Abstract Not Available]Öğe The Better Performance Status, the Better Outcome: Laryngeal Carcinoma Treated with Definitive Radiotherapy(B C Decker Inc, 2008) Yurut-Caloglu, Vuslat; Caloglu, Murat; Turan, Fatma Nesrin; Ibis, Kamuran; Karagol, Hakan; Kocak, Zafer; Uzal, CemPurpose: To evaluate the prognostic factors affecting locoregional control (LRC) and overall survival (OS) of patients with laryngeal carcinoma who were not candidates for surgical treatment due to tumour or host factors but were treated with definitive radiotherapy (RT). Patients and Methods: Sixty-three consecutive patients, treated with definitive RT between 1999 and 2005, were retrospectively analyzed. All patients had histologically proven squamous cell carcinomas of the larynx. The median age was 62 years (range 43-83 years). Follow-up ranged from 22 days to 68 months (median 32 months). Results: The LRC rates at 2 and 5 years were 70% and 48%. The 2- and 5-year OS rates were 65% and 40%. No statistically significant relationship was found between World Health Organization performance status score (WHO PS) and age (p = .21), tumour site (p = .42), overall stage (p = .11), T stage (p = .19), and N stage (p = .69). Multivariate analyses showed that a WHO PS score >= 2 (p < .0001) and RT treatment time >= 50 days (p = .0172) significantly decreased LRC. Moreover, a WHO PS score >= 2 (p < .0001), RT treatment time >= 50 days (p = .0138), and RT dose < 66 Gy (p = .04) were significantly negative prognostic factors on OS. Conclusion: Definitive RT, in patients with early- and more advanced-stage squamous cell carcinoma of the larynx, is an important treatment option. It is clear that patients with good pretreatment PS would get better results from definitive RT.Öğe Carnitine or dimethyl sulfoxide, or both, for the treatment of anthracycline extravasation in rats(Informa Healthcare, 2013) Uzunoglu, Sernaz; Cosar, Rusen; Cicin, Irfan; Ibis, Kamuran; Demiralay, Ebru; Benlier, Erol; Erdogan, BulentThis study aimed to compare the efficacy of topical dimethyl sulfoxide (DMSO), intralesional and systemic carnitine as monotherapy and in combination against ulceration in rats induced by intradermal doxorubicin extravasation. Sixty-nine 3-month-old male Wistar albino rats, weighing between 200-225 g, were used in this study. Rats were applied monotherapy or a combination of topical DMSO, intraperitoneal or intralesional carnitine. Control groups received saline or no drug. The necrotic area was measured and extravasated neutrophil leukocytes were counted in healthy tissue adjacent to necrotic areas. Monotherapy with topical and systemic carnitine did not significantly reduce the size of necrotic areas. However, topical DMSO had reduced necrotic areas and inflammatory cells significantly and the addition of systemic carnitine to topical DMSO had increased the efficacy. DMSO is an effective, safe, and easy-to-apply treatment for doxorubicin-induced extravasation. Further clinical studies are needed to evaluate the use of carnitine in combination with DMSO.Öğe Cutaneous metastasis of epidermoid carcinoma of the larynx: a case report(Kare Publ, 2006) Ibis, Kamuran; Ibis, Cem; Yurut-Caloglu, Vuslat; Altaner, Semsi; Caloglu, Murat; Karagol, Hakan; Cosar-Alas, RusenThe frequency of distant metastasis of epidermoid carcinoma of the larynx is between 6.5-7.2%. The common sites of metastasis are lung, liver and bone. Cutaneous metastasis is very rare. A 56-year-old male with locally advanced larynx carcinoma who received curative radiochemotheraphy a year ago was presented to our department with subcutaneous nodular lesions, and fatigue. Physical examination revealed 0.5 cm sized, and 1x1cm sized subcutaneous nodular lesions in the right arm, and in the parasternal area, respectively. Histopathologic examination confirmed the skin metastasis of epidermoid carcinoma of the larynx. The patient has profound anemia, hypercalcemia, hypernatremia, and hyperglicemia with complicated diabetic foot. Although the symptomatic treatment began immediately, the patient died on the third day of hospitalisation. Cutaneous metastasis may be the first sign of local failure, of distant metastasis, or even of the undetected laryngeal carcinoma with poor prognosis.Öğe Factors affecting local control, distant recurrence and survival in patients with locally advanced bladder cancer treated by definitive radiotherapy or chemoradiotherapy(Kare Publ, 2006) Caloglu, Murat; Yurut-Caloglu, Vuslat; Saynak, Mert; Cosar-Alas, Rusen; Karagol, Hakan; Kaplan, Mustafa; Ibis, KamuranOBJECTIVES Treatment results of 34 patients with bladder cancer admitted to Department of Radiation Oncology, Medicine Faculty of Trakya University between October 1997 and June 2005 were retrospectively analyzed. Prognostic factors associated with survival were determined. METHODS Their median age was 69 years (range 44-93). Thirty patients (88%) were male and 4 patients (12%) were female. Histopathological diagnosis was transitional cell carcinoma in 20 (59%) patients. Chemotherapy was administered concomitantly with radiotherapy to the 11 (32.35%) of the patients. The median radiotherapy dose was 62.5 (35-68) Gy. The median follow-up was 22 months (5-76 months). Median survival and median disease-free survival were 14.2 months (3.8-57.5) and 10 months (0-55), respectively. RESULTS Three years loco-regional control, metastasis free survival, disease free survival and overall survival rates were 76.59 , 72.2%, 55% and 41.1%, respectively. Epidermoid carcinoma histopathology (p=0.002), not performing concomitant chemotherapy (p=0.003), applying carboplatin instead of cisplatin with radiotherapy (p=0.004) and not conducting complete TURB (p=0.008) were significant poor prognostic factors on loco-regional control. Undifferentiated cell type (p=0.012) and not performing concomitant chemotherapy (p=0.046) were significant adverse factors on distant metastases. Factors that affect overall survival were tumor in stage T-4 (p=0.05), hemoglobin value below 10 g/dl (p=0.032) and not performing concomitant chemo-radiotherapy (p=0.017) and complete TURB (p=0.049). CONCLUSION Complications of radiotherapy were acceptable. For the treatment of muscle invasive locally advanced bladder cancer, RT combined with cisplatin is an acceptable treatment option. Moreover, complete TURB before RT is important both for local control and for survival.Öğe MARJOLIN'S ULCER IN SCALP: CASE REPORT AND LITERATURE REVIEW(Kare Publ, 2005) Caloglu, Murat; Yurut Caloglu, Vuslat; Cosar Alas, Rusen; Ibis, Kamuran; Altaner, Semsi; Uzal, CemMarjolin's ulcer is a rare skin cancer that originates in areas of chronic wounds and scar tissues. It has more aggressive nature than other primary skin cancers. The exact mechanism of tumor development has not yet been identified. It could be seen on the skin of whole body surface. The most common histopathologic type of this malignancy is squamous cell carcinoma. It could develop in early and late period of time after trauma. Although surgery is still the main treatment, radiotherapy and chemotherapy could be other options in appropriate circumstances. In the present case report we described a patient who had lost her scalp in a work accident 25 years ago and developed skin cancer on scar tissue in late period, with a literature review.Öğe Palliative radiotherapy for malign melanoma: a case report(Kare Publ, 2006) Yurut-Caloglu, Vuslat; Caloglu, Murat; Tokatli, Fusun; Kocak, Zafer; Cosar-Alas, Rusen; Ibis, Kamuran; Karagol, HakanMalignant melanoma is a skin cancer with poor prognosis. Historically melanoma has been thought of as a relatively radioresistant tumour. Nowadays, radiation delivered according to hypofractionated schedule is the most used, although there are few data confirm that this schedule improves the therapeutic impact. We report a case, with stage IV malignant melanoma, whose tumoral bleeding was palliated successfully giving 20 Gy external radiotherapy in 5 fractionations.Öğe Pancreas is an Unusual Initial Metastatic Site of Intracranial Hemangiopericytoma(Kare Publ, 2016) Ibis, Kamuran; Saynak, Mert; Yalta, Tulin; Ibis, Cem; Kocak, Zafer; Karadeniz, AhmetIntracranial hemangiopericytoma (HPC) is rare and aggressive tumor with local recurrences as well as distant metastases. The majority of metastases are encountered in bone, lung, and liver. Pancreatic metastasis is extremely rare. Described in the present report is the case of a 41-year-old woman who had undergone surgical resection of intracranial HPC 16 years earlier. The tumor recurred 3 years after the operation and was successfully managed with surgery followed by adjuvant radiotherapy. Thirteen years later, an isolated pancreatic metastasis developed. Patient underwent Whipple procedure for pancreatic head lesion and received adjuvant radiotherapy. Patient died of extensive disease in lungs, bones, mediastinum, cranium and peritoneal carcinomatosis in abdomen 17 months after pancreatic surgery.Öğe Radiation-induced chronic oxidative renal damage can be reduced by amifostine(Humana Press Inc, 2012) Cosar, Rusen; Yurut-Caloglu, Vuslat; Eskiocak, Sevgi; Ozen, Alaattin; Altaner, Semsi; Ibis, Kamuran; Turan, NesrinIn the current study, amifostine is evaluated for its radioprotective role in serum and kidney tissue by oxidative (malondialdehyde-MDA, advanced oxidation protein product-AOPP) and antioxidative markers (catalase, glutathione-GSH, free-thiols-F-SH). Thirty Wistar albino 3-4 months old, female rats, were randomly divided into Group I (n = 10): Control, Group II (n = 10): Irradiation-alone, Group III (n = 10): Amifostine before irradiation. In Group II and III, right kidneys of the rats were irradiated with a single dose of 6 Gy using a 60Co treatment unit. Rats in Group III received 200 mg/kg amifostine intraperitoneally, 30 min prior to irradiation. Following sacrification at 24th week, blood and kidney tissue samples were collected. Statistical analysis was done by One-way ANOVA, Post hoc Bonferroni, Dunnett T3, and Mann-Whitney U tests. Administration of amifostine significantly decreased the serum AOPP and MDA levels when compared to the irradiation-only group (P = 0.004, P = 0.006; respectively). Also amifostine significantly increased serum catalase activities and GSH levels, when given 30 min prior to irradiation (P = 00.02, P = 0.000; respectively). In the kidney tissue, administration of amifostine significantly decreased AOPP and MDA levels (P = 0.002, P = 0.016; respectively). Tissue GSH activity was increased following amifostine administration (P = 0.001). There was no statistically significant result on histopathological evaluation. Amifostine may reduce radiation-induced nephropathy by inhibiting chronic oxidative stress. Biomarkers of oxidative stress in serum and kidney tissue may be used for evaluation of the radiation-induced nephropathy.Öğe An unusual metastatic site of tongue carcinoma: Shoulder muscles(Elsevier Sci Ltd, 2008) Yurut-Caloglu, Vuslat; Caloglu, Murat; Oz-Puyan, Fulya; Unlu, Ercument; Karagol, Hakan; Ibis, Kamuran; Uzal, CemThe incidence of skeletal Muscle metastases is reported to be less than 1% of metastases of haematogenous origin. Distant skeletal muscle metastases from head and neck squamous cell carcinomas are exceedingly rare. Only a case with tongue carcinoma metastasized to paravertebral muscles, has been reported so far. The reasons for the rarity of metastatic involvement of skeletal muscle are still unclear. The presence of skeletal muscle metastases in the setting of disseminated disease offers no hope for Curative treatment. We report an unusual case of a 63-year-old patient with tongue carcinoma metastasizing to the left shoulder Muscles. To our knowledge, this is the first such case to be reported in the English medical literature. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
