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Öğe Assessment of Tc-99m sestamibi tumor tissue uptake under the influence of increased arterial oxygen saturation(Elsevier Science Inc, 2005) Cermik, TF; Altiay, G; Firat, MF; Hatipoglu, ON; Berkarda, SThe aim of this study is to investigate the potential effect of increased arterial saturation of oxygen in the magnitude of technetium-99m-hexakis-isobutyl-isonitrile ((99)mTc-MIBI) uptake in tumor tissue and to compare the results with those of conventional Tc-99m-MIBI tumor imaging in the same patient with lung cancer. A total of 26 lung cancer patients underwent initial SPECT (I-SPECT) and after oxygen inhalation SPECT (O-2-SPECT). The early (ER) and delayed ratios (DR) Of O-2-SPECT mean +/- S.D. were significantly higher than those of I-SPECT mean +/- S.D. (2.07 +/- 0.57 vs. 1.90 +/- 0.48 and 2.02 +/- 0.45 vs. 1.83 +/- 0.39, respectively). There are increased rates for the relative tumor uptake of Tc-99m-MIBI by 9% for ER and 10% for DR on the O-2-SPECT compared to I-SPECT. We found that 99mTc-MIBI uptake increased significantly in the tumor tissue with O-2-SPECT compared to I-SPECT. In conclusion, 99mTc-MIBI scintigraphy is one of the main methods for differentiating viable and nonviable tissue fractions in tumors. We consider that 99mTc-MIBI uptake increase after oxygen inhalation is an indicator of positive acute cellular response of the tumor tissue to the rising tissue oxygen level. (c) 2005 Elsevier Inc. All rights reserved.Öğe A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia(Yonsei Univ College Medicine, 2000) Hatipoglu, ON; Tasan, YThe efficacy and safety of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia were compared in an open randomized trial. Eighty-six male patients, doing their obligatory military service, ranging between 19 and 24 years of age (mean 20), were randomly treated: 29 with clarithromycin 500 mg 12-hourly, 30 with roxithromycin 150 mg 12-hourly, and 27 with erythromycin stearate 500 mg 6-hourly, each course being administered for 10 days. Seventy-eight patients were able to be evaluated for efficacy, 28 receiving clarithromycin, 28 roxithromycin, and 22 erythromycin stearate. There were no significant differences among the groups in terms of clinical success rates (clinical cure or improvement: 89% for clarithromycin, 82% for roxithromycin, and 73% for erythromycin stearate, p = 0.32). However, we found chat there were significant differences among the groups in terms of clinical cure rates (75% for clarithromycin, 64% for roxithromycin, and 41% for erythromycin stearate, p = 0.04). Adverse events, mostly gastrointestinal, caused discontinuation of treatment in 3.4% of the patients in the clarithromycin group, in 6.6% of the patients in the roxithromycin group, and in 18.5% of the patients in the erythromycin stearate group. The results indicate that there were no statistically significant differences among the three treatment groups in terms of clinical success rates, but that clarithromycin and roxithromycin were better tolerated.Öğe Levels of superoxide dismutase and malondialdehyde in primary spontaneous pneumothorax(Carfax Publishing, 2004) Tabakoglu, E; Ciftci, S; Hatipoglu, ON; Altiay, G; Caglar, TTHE aim of the present study is to determine whether patients with primary spontaneous pneumothorax (PSP) are subject to oxidative stress. For this purpose, we measured the activities of red blood cell superoxide dismutase, which is an antioxidant enzyme, and the level of plasma malondialdehyde, which is one of the lipid peroxidation markers, in a group of patients with PSP. The study was carried out with 16 patients with PSP and 24 healthy individuals. The two groups were similar to each other in terms of sex, age and smoking attitudes. Erythrocyte superoxide dismutase activity was found to be significantly lower in patients with PSP than in the control group (p < 0.01). The plasma malondialdehyde levels were significantly high in patients with PSP (p < 0.01). Our results suggest that oxidative stress may contribute to the pathogenesis of PSP.
