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Öğe Analgesic effect of metformin on hyperalgesia induced by REM sleep deprivation(Wiley, 2023) Gurel, Elif Ezgi; Ozturk, Gulnur; Ozturk, Levent; Tosunoglu, Esra Akbas; Gul, Tugba Kizil; Arslan, Enver[Abstract Not Available]Öğe The Effect of Ginkgo Biloba on Hyperalgesia Induced by REM Sleep Deprivation(Wiley, 2023) Gurel, Elif Ezgi; Ozturk, Levent; Ozturk, Gulnur; Deger, Ecem Busra; Tosunoglu, Esra Akbas[Abstract Not Available]Öğe The Effect of Metformin on Hyperalgesia Induced by REM Sleep Deprivation(Wiley, 2022) Gurel, Elif Ezgi; Ozturk, Gulnur; Gunduz, Samime Sarli; Tosunoglu, Esra Akbas; Ozturk, Levent[Abstract Not Available]Öğe The Effect of Resveratrol on Hyperalgesia Induced by REM Sleep Deprivation(Wiley, 2023) Gurel, Elif Ezgi; Ozturk, Levent; Ozturk, Gulnur; Gunduz, Samime Sarli; Deger, Ecem Busra[Abstract Not Available]Öğe Flurbiprofen in rapid eye movement sleep deprivation induced hyperalgesia(Pergamon-Elsevier Science Ltd, 2014) Gurel, Elif Ezgi; Ural, Keremcan; Ozturk, Gulnur; Ozturk, LeventBackground: Rapid eye movement (REM) sleep deprivation induces hyperalgesia in healthy rats. Here, we evaluated the effects of flurbiprofen, an anti-inflammatory and neuroprotective agent, on the increased thermal responses observed in REM sleep deprived rats. Methods: Forty female rats were divided into four groups following 96-hour REM sleep deprivation: intraperitoneal injections of placebo, and flurbiprofen 5 mg/kg, 15 mg/kg and 40 mg/kg were made in CONT (n = 10), FBP5, FBP15 and FBP40 groups respectively. Pain threshold measurements were performed three times at baseline (0.hour), at the end of REM sleep deprivation (96.hour) and at 1 h after injections (97.hour) by hot plate and tail-flick tests. Results: REM sleep deprivation induced a significant decrease in pain thresholds of all rats (hotplate: 0.hour vs 96.hour, 9.75 +/- 2.85 vs 5.10 +/- 2.02, p < 0.001; tail flick: 0.hour vs 96.hour, 11.92 +/- 4.62 vs 7.92 +/- 5.15, p < 0.001). Flurbiprofen in 15 mg/kg and 40 mg/kg doses significantly improved pain tolerance measured by tail flick test (tail flick in FBP15 and FBP40 groups: 96.hour vs 97.hour, 7.01 +/- 4.97 vs 8.34 +/- 3.61 and 5.06 +/- 1.57 vs 7.04 +/- 2.49, p < 0.05 for both). Conclusion: 96 h of REM sleep deprivation resulted in reduced pain thresholds in both hot plate and tail flick tests. Flurbiprofen was used for the first time in a rat model of REM sleep deprivation, and it provided antinociceptive effects in 15 mg/kg and 40 mg/kg doses. Flurbiprofen may have the potential for treatment of painful syndromes accompanying insomnia or sleep loss. (C) 2014 Elsevier Inc. All rights reserved.Öğe Hemodynamic effects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs after exercise(Tubitak Scientific & Technological Research Council Turkey, 2015) Vardar, Selma Arzu; Palabiyik, Orkide; Topuz, Ruhan Deniz; Gurel, Elif Ezgi; Caliskan, Semra; Topcu Ozen, Serap; Sut, NecdetBackground/aim: Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes. We compared the hemodynamic effects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed by reperfusion in exercised rat hearts with nonexercised ones. Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups after a running protocol for 5 days and 4 nonexercised (NE) groups. In the first protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the second protocol, different doses of isatin (0.1, 10, 100 mu M/L) were added to the perfusion solution before ANP in 3 E and 3 NE groups. Left ventricular developed pressure (LVDP) and maximum and minimum rates of change in left ventricular pressure (dP/dtmax and dP/dtmin) were recorded. Results: Higher LVDP and dP/dtmin values were observed in the E group than the NE group following addition of ANP before ischemia. Values of dP/dtmax were higher in the E group at the first minute of reperfusion period. Hemodynamic difference was not observed between groups given the same amount of isatin before ANP. Conclusion: This study indicated that higher ANP concentrations before ischemia were more effective on the left ventricle contractility and relaxation functions in the hearts that were exposed to exercise.Öğe Stress-Induced Heart Rate Variability Under The Conditions of Acute Sleep Deprivation: Effects of Caffeine or Nap(Wiley, 2023) Kurtaran, Nurcan Erdogan; Ozturk, Gulnur; Gunduz, Samime Sarli; Gurel, Elif Ezgi; Erge, Ummuhan; Ozturk, Levent[Abstract Not Available]
