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    Endothelial Nitric Oxide Synthase Immunreactivity and the Ultrastructure of Endothelial Cells of Umbilical Artery in Normal and Preeclamptic Pregnancies
    (Taylor & Francis Inc, 2010) Kanter, Mehmet; Gurbuz, Hulya; Okman, Tulay Kilic
    Our objective was to investigate the endothelial nitric oxide synthase (eNOS) immuno-reactivity and the ultrastructure of endothelial cells of a human umbilical artery in both normal and preeclamptic pregnancies. The umbilical cords from normal and preeclamptic pregnancies were collected immediately after vaginal and abdominal deliveries. Umbilical arteries were isolated and fixed in 10% neutral formaline solution, embedded in paraffin, and then stained with hematoxylin and eosin (H&E) for the histologic investigation, and eNOS activation were examined in samples by streptavidine-biotine immunohistochemical methods. The arterial sections were also fixed in phosphate-buffered 2.5% glutaraldehyde solution (pH 7.2) for 3 h and post-fixed with 1% osmium tetroxide at 4 C for 2 h for the investigation of the ultrastructural examination. In the umbilical artery of preeclamptic pregnancies, endothelial cells were oval, triangular, or polygonal, and were disorganized. Some endothelial cells were separated by enlarged intercellular spaces. A dilated endoplasmic reticulum, swollen mitochondria, and vanished mitochondrial cristae were observed. The nuclei of some endothelial cells displayed deep invaginations and irregular outlines. Most endothelial cells had a high number of cytoplasmic vacuoles. In preeclampsia, eNOS immunoreactivity increased considerably in endothelial cells when compared to normal pregnancies. We believe that preeclampsia plays an important role in the pathogenesis of endothelial cell dysfunction and activation in the umbilical artery. However, the disturbance mechanism of endothelial cells is not known, and further studies are necessary to clarify the exact mechanism.
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    Symphysis pubis distance in adults: a retrospective computed tomography study
    (Springer France, 2008) Alicioglu, Banu; Kartal, Ozcan; Gurbuz, Hulya; Sut, Necdet
    Background In this retrospective study, symphysis pubis (SP) distance was measured by transverse computed tomography scans. The relation between the SP distance and age, gender, number of birth and body-mass index was studied. Methods Symphysis pubis joint distances were evaluated for the patients who had undergone abdominal or pelvic computed tomography examination for other medical reasons between the dates of March and May 2007. Anterior, middle, and posterior SP joint distances were measured at transverse planes. Normal joint width in women and men was determined. The relation between obtained values, and age, gender, number of birth, as well as body-mass index was studied. Results Symphysis pubis narrows at anterior concurrently with ageing (r = -0.115; P = 0.007). Narrowing, though less, is also observed at posterior (r = -1.50 P = 0.000); however, middle part does not change (r = 0.030; P = 0.489). Number of birth and body-mass index values do not affect SP width. The widths measured at anterior and middle of the SP were significantly higher in women (P = 0.010 and P = 0.002). Conclusions Osteoarthritic changes develop in SP with ageing. However, osteoarthritis in SP, was found to be clinically and radiologically different from that in other symphyseal joints, as SP hardly ever moves, and vertically processing interpubic disc combines pelvis girdle with counterforces, and is supported by very strong ligaments and muscles. Anterior and middle part of the SP joint is wider in women, because fibrocartilaginous disc is too thick to provide the mobility.
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    Symphysis pubis distance in adults: a retrospective computed tomography study (vol 30, pg 153, 2008)
    (Springer, 2008) Alicioglu, Banu; Kartal, Ozcan; Gurbuz, Hulya; Sut, Necdet
    [Abstract Not Available]
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    The synovial plicae in the knee joint
    (Saudi Med J, 2006) Gurbuz, Hulya; Capur, Osman U.; Ozcan, Mert; Kutoglu, Tunc; Mesut, Recep
    Objectives: To investigate and evaluate the prevalence of 4 kinds of synovial plicae named according to patella, which are inferior, medial, lateral and superior. Methods: We evaluated plicae in 318 knee arthroscopies through video records. obtained from January 1994 to December 2002 in the Arthroscopy Unit, Department of Orthopedic Surgery, Faculty of Medicine, Trakya University, Edirne, Turkey. In addition, we also investigated plicae in 7 bilateral knee cadavers. Results: In the arthroscopic evaluation, the prevalence of infrapatellar synovial plica was 194 (61%), mediopatellar plica was 302 (95%), lateral patellar plica was 66 (20.7%) and suprapatellar plica was 184 (57.8%). We found that there were 8 (57%) infrapatellar synovial plicae, 13 (92%) mediopatellar plicae, 7 (50%) lateral patellar plicae and 6 (42%) suprapatellar plicae in 14 cadaveric knees. Conclusions: We observed a high prevalence of lateral plicae and mediopatellar plicae on the cadavers and the people with arthroscopic diagnosis, and believe our results can contribute to knee anatomy and surgery.