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Öğe Arylsulfonamidothiazoles for the early stages of Alzheimer type dementia: A new potential for treatment(Churchill Livingstone, 2011) Guldiken, Sibel; Guldiken, Baburhan[Abstract Not Available]Öğe Association Between Matrix Metalloproteinase-9 C-1562T Gene Polymorphism and Ischemic Stroke(Galenos Publ House, 2023) Kara, Ismail; Sipahi, Tammam; Sunal, Asli Sert; Yildiz, Mustafa; Guldiken, BaburhanObjective: Matrix metalloproteinases (MMPs) are calcium-dependent zinc-containing proteases containing more than 28 enzymes that cause the degrading of the extracellular matrix. Although MMPs play key roles in many biological processes, they influence some pathological processes such as ischemic stroke (IS). Among MMPs, the enzyme most associated with IS is the MMP9 enzyme. This study aimed to evaluate the effect of the C-1562T (rs3918242) gene polymorphism of MMP9 on the development of IS in Turkish patients living in the Trakya Region.Materials and Methods: Our study involved 60 patients with IS and 60 controls. The patients with IS were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment classification of stroke subtypes, and MMP9 C-1652T gene polymorphism was identified using polymerase chain reaction, followed by restriction fragment length polymorphism using the Pael (SphI) restriction enzyme.Results: Genotypes were defined as CC, CT, and TT according to the presence of C and T alleles. No significant differences were identified in the genotype distribution and allele frequency of MMP9 C-1562T gene polymorphism between the patients with IS and controls.Conclusion: Our findings suggest that MMP9 C-1562T gene polymorphism is not associated with the risk of IS in Turkish patients living in the Trakya Region.Öğe The Association of Gene Polymorphisms of the Angiotensin-Converting Enzyme and Angiotensin II Receptor Type 1 with Ischemic Stroke in Turkish Subjects of Trakya Region(Aves Yayincilik, Ibrahim Kara, 2009) Sipahi, Tammam; Guldiken, Baburhan; Guldiken, Sibel; Ustundag, Sedat; Turgut, Nilda; Budak, Metin; Cakina, SuatObjectives: The aim of this study was to investigate the frequency of ACE insertion/deletion (I/D) and AT1R (A1166C) gene polymorphisms in ischemic stroke patients in Trakya region and the relation between these gene polymorphisms and stroke subtypes and vascular risk factors. Patients and Methods: The study involved 162 patients with ischemic stroke and 146 control subjects. Ischemic stroke patients were divided into large and small vessel disease subgroups according to ORG 10172 in Acute Stroke Treatment TOAST criteria. The ACE I/D polymorphism was investigated using polymerase chain reaction (PCR), and the AT1R (A1166C) polymorphism was identified using PCR and restriction fragment length polymorphism (RFLP) assay. Results: The ACE I/D genotype distribution in patients (DD=34.0%, ID=50.0%, II=16.0%) did not differ from those in controls (DD=34.3%, ID=49.7%, II=16.1%). The AT1R A1166C genotype distribution in patients (AA=58.0%, CA=34.6%, CC=7.4%) did not significantly differ from those in controls (AA=60.1%, CA=35.7%, CC=4.2%). There was also no difference among the stroke subgroups regarding the distribution of ACE I/D and AT1R (A1166C) polymorphisms. Conclusion: Our results show that ACE I/D and AT1R (A1166C) gene polymorphisms were not genetic risk factors for ischemic stroke in subjects in Trakya region.Öğe Bilateral Basal Ganglia Lesions Associated with Lactic Acidosis in an End-Stage Renal Failure Patient(Turkish Neurological Soc, 2009) Guldiken, Baburhan; Ustundag, Sedat; Yilmaz, Arif; Cakir, HasanAlthough bilateral basal ganglia lesions are common in hypoxic encephalopathy and methanol intoxication, they are a rare finding in end-stage chronic renal failure. The pathophysiology of both bilateral and selective involvement of the basal ganglia is unclear, but severe metabolic acidosis is one of the affected processes. In this report bilateral basal ganglia lesions and accompanying signs, which ensued after the use of metformin in a patient with chronic renal failure, are discussed.Öğe Calcitonin Gene Related Peptide Gene Polymorphism in Migraine Patients(Cambridge Univ Press, 2013) Guldiken, Baburhan; Sipahi, Tammam; Tekinarslan, Remziye; Kabayel, Levent; Ozkan, Hulya; Unlu, Ayhan; Yamasan, Bilge ErenObjective: Calcitonin gene related peptide (CGRP), which has a vasodilator effect, is held responsible for neurogenic inflammation and vasodilatation of the cranial vessels in migraine pathophysiology. In this study, we investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine. Material and Methods: One hundred and thirty-four female migraineurs and 96 healthy female cases were enrolled in the study. The patient group was further subdivided into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase chain reaction (PCR) technique and restriction fragment length polymorphism (RFLP). Results: The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between the migraine and control groups. Between the migraine with and without aura subgroups, there was no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity and frequency. Conclusion: Our study did not show any association between CALCA T-692C gene polymorphism and migraine.Öğe Calcitonin related polypeptide alpha gene polymorphisms according to plasma total homocysteine levels in ischemic stroke patients of Trakya Region(Taylor & Francis Ltd, 2017) Alkanli, Nevra; Sipahi, Tammam; Ay, Arzu; Guldiken, Baburhan; Bakir, Alev; Alkanli, Suleyman Serdar; Celebi, CananThe aim of this study was to determine the genotype distributions of calcitonin related polypeptide alpha (CALCA) gene polymorphisms according to the plasma total homocysteine levels in ischemic stroke patients and patient subtypes selected from Trakya Region. The study included 82 patients and 92 healthy controls. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to determine the genotype distributions of CALCA gene polymorphisms. The plasma total homocysteine levels were measured by Immulite 2000XPi homocysteine kits. Significant differences were not found between the group of patients and the control group in terms of CALCA gene polymorphisms genotype distributions (p > 0.05). Significant differences were not found between ischemic stroke patients and healthy controls, in the patient subtypes with ischemic stroke in respect to the CALCA gene polymorphisms genotype distributions according to the plasma total homocysteine levels (p > 0.05). This suggests that the CALCA gene polymorphisms genotype distributions studied according to the plasma total homocysteine levels could not likely be considered a genetic risk factor for ischemic stroke development.Öğe A Case of Autoimmune Encephalitis with Refractory Status Epilepticus(Kare Publ, 2019) Cakar, Merve Melodi; Aksar, Aslihan; Akpinar, Meliha; Mercan, Elif; Kehaya, Sezgin; Guldiken, BaburhanRefractory status epilepticus is usually caused by a severe brain injury and has a high rate of mortality and morbidity despite the infusion of antiepileptic drugs and anesthetic agents. Autoimmune encephalitis is one cause of refractory status epilepticus and status epilepticus may be the initial symptom. The seizures are generally resistant to standard treatment and may require immunotherapeutics. This is a description of a patient who had refractory status epilepticus despite appropriate doses of antiepileptic and general anesthetic drugs, but responded to intravenous immunoglobulin therapy. Examinations revealed an ovarian teratoma with a negative serum N-methyl-D-aspartate receptor antibody.Öğe Cognitive Dysfunction in Chronic Renal Disease: Impact of Dialysis Modality(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2015) Ak, Recep; Ustundag, Sedat; Ustundag, Ayten; Guldiken, Baburhan; Sut, NecdetOBJECTIVE: Cognitive dysfunction (CD) is common among patients with chronic kidney disease (CKD) and contributes to morbidity and mortality. We aimed to explore the factors involved in the development of CD in patients with CKD and to compare cognitive function between hemodialysis (HD) and peritoneal dialysis (PD) patients. MATERIAL and METHODS: We studied 122 patients with different stages of CKD, and divided them into two groups: Predialysis Group: included 60 CKD patients, (28 stage III and 34 stage IV); Dialysis Group: included 60 patients on dialysis therapy, (30 on HD and 30 on PD). Psychometric tests were done all patients. The results were compared with 41 healthy subjects. RESULTS: We found that the CD rate was higher in patients with CKD (24.6%) than controls (0%, p<0.001). The Mini Mental Test score was found to be correlated with age (r=-0.428), hemoglobin (r=0.336), CRP (r=-0.311), and albumin (r=0.336); the Calculation Test score was found to be correlated with LDL cholesterol (r=-0.336); the Praxis Test Score was found to be correlated with duration of CKD (r=-0.204), HDL (r=0.188); and the Visual Memory Test score was found to be correlated with parathormone levels (r=-0.270). We found the CD rate to be higher in patients on HD (50%) than on PD (23.3%, p=0.032). CONCLUSION: Our findings suggest that anemia, malnutrition and inflammation play an important role in the development of CD in our patients, and cognitive functions are better preserved in the PD group than the HD group.Öğe Endothelial Nitric Oxide Synthase and Angiotensin Converting Enzyme Gene Polymorphisms in Migraine Patients(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2013) Sipahi, Tammam; Guldiken, Baburhan; Kabayel, Levent; Palabiyik, Orkide; Ozkan, Hulya; Okman Kilic, Tulay; Sut, NecdetIntroduction: In this study, we investigated the association of migraine with the Variable Number of Tandem Repeats (VNTR), repeated as 27 base pair, gene polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) and the insertion/deletion of angiotensin converting enzyme (ACE) gene polymorphisms. Methods: One hundred and five migraine and ninety seven healthy female control subjects were enrolled in the study. The patients were subdivided as migraine with aura and without aura, and the frequency and severity of migraine headaches were recorded. The eNOS VNTR (eNOS 4 a/b) and ACE insertion/deletion gene polymorphisms (ACE I/D) were assessed by polymerase chain reactions. Results: The allele and genotype frequencies of eNOS 4 a/b gene polymorphism showed no difference between the migraine and control groups. The genotypic distribution of the ACE I/D gene polymorphism in the migraine group significantly differed from that in the control group. The DD and ID genotype increased the risk of migraine as much as 2.571 (95% CI-1.138-5.811) and 4.453 (95% CI-2.006-9.883) compared to the II genotype. The same increased risk sustained for both genotypes in the migraine with aura subgroup, but only the ID genotype remained as the risk factor in the migraine without aura subgroup (OR-3.750, 95% CI-1.493-9.420). No association of gene polymorphisms with migraine frequency and severity was observed. Conclusion: Our findings support the relationship between migraine and the ACE I/D gene polymorphism. However, no association was found between migraine and the eNOS 4 a/b gene polymorphism.Öğe An epidemiologic investigation of amyotrophic lateral sclerosis in Thrace, Turkey, 2006-2010*(Taylor & Francis Ltd, 2019) Turgut, Nilda; Saracoglu, Gamze Varol; Kat, Selahattin; Balci, Kemal; Guldiken, Baburhan; Birgili, Ozlem; Kabayel, LeventObjective: The aim of the study was to investigate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Thrace, Turkey in a five-year time period (2006-2010). Methods: Study population included residents of three provinces (Edirne, Tekirdag, Kirklareli) in the Thrace region. Cases were ascertained from all of the neurologic centers and hospitals of these provinces. Demographic and clinical information was collected for each patient. Newly diagnosed ALS patients who are fulfilling the El Escorial revised diagnostic criteria were enrolled into the study. Results: We identified a total of 145 patients (93 males, 52 females). The mean age at diagnosis was 57.0 +/- 13.6. According to El Escorial criteria, 60.0% of the cases were definite ALS, 24.8% were probable, and 15.2% were possible ALS. Thirty-two cases were bulbar (22.1%), 113 cases (77.9%) were spinal onset. Mean time delay from onset to diagnosis was 12.0 +/- 11.2 months. Age-gender standardized incidence rates with reference to Turkey, USA 2008 census were 1.9 (95% confidence interval (CI), 1.8-2.1), 1.9 (95%CI, 1.8-2.2) for overall. There were 112 living ALS patients at the end of the study. Crude point prevalence was calculated as 7.3 per 100,000 population (95%CI, 5.9-8.7). Conclusions: This is the first study to provide fundamental data about demographic and clinical characteristics about ALS in Thrace region of Turkey. Incidence and prevalence of ALS in Thrace region of Turkey appear to be comparable with European countries.Öğe The Evaluation of The Agreements of Different Epilepsy Classifications in Seizures Recorded With Video EEG Monitoring(Journal Neurological Sciences, 2012) Guldiken, Baburhan; Baykan, Betul; Sut, Necdet; Bebek, Nerses; Gurses, Candan; Gokyigit, AysenObjective: The main purpose of the epilepsy classifications is to guide physicians to get the correct diagnosis and subsequently select the appropriate treatment. When using the daily classifications, the diagnosis and treatment of some patients sometimes remain unsatisfying, and video EEG monitoring (VEM) is the alternatively applied diagnostic tool in such patients. In the present study, the agreement of different classifications before and after short term VEM is investigated. Methods: Three hundred ninety-one patients who had undergone VEM were enrolled in the study. Forty-five cases, whose epileptic seizures could be recorded, were classified before and International League Against Epilepsy (ILAE) Commission on Terminology and Classification, and Semiological Seizure Classification reported by Luders et al. in 1998. Results: The intra-observer agreements of Semiological Seizure, 1989 and 2010 Electroclinical Syndrome Classifications were found to be substantial, whereas those of 1981 and 2010 Epileptic Seizure Classifications were moderate. The initial clinical diagnosis was changed in 44.7% to 56.5% of patients where a change of treatment was needed in 36.5% of the cases. Conclusion: While the Semiological Seizure Classification appears to be more consistent than the 1981 and 2010 Seizure Classifications, the impact of short term VEM on the accurate classification is remarkable.Öğe Factors affecting long-term prognosis in adult patients with psychogenic non-epileptic seizures(Literatura Medica, 2024) Turksever, Meliha; Guldiken, Baburhan; Ozkan, Hulya; Cakar, Merve MelodiBackground and purpose - Among epileptic patients who are monitored using the video-electroencephalography monitoring (VEM) technique, in some patients a psychogenic non-epileptic seizure (PNES) can be identified as a definitive diagnosis. The long-term prognosis of these patients is not well known. In this study, we aimed to determine the factors that affect the prognosis of PNES. Methods - Forty-one PNES patients diagnosed using VEM between 2012 and 2022 were questioned about their PNES frequencies in the last 12 months. According to their semiological characteristics, PNES types were divided into motor and non-motor seizures. The effects of clinical characteristics (e.g. age, gender, marital status, education level and PNES type) on the prognoses were identified. Results - Twenty-one PNES patients (51.2%) had long-term seizure freedom after VEM. Thirteen of them (31.7%) entered the seizure-free period immediately after VEM, and the other eight (19.5%) continued suffering from PNES for several years and became seizure free in the last 12 months. In the poor-prognosis group, female cases showed worse prognoses than male cases. The prognoses of motor and non-motor PNES types did not show significant differences. Conclusion - This study showed that 51.2% of the PNES patients examined had long-term seizure freedom and that female patients had worse prognoses than male patients.Öğe Factors affecting the quality of life in drug-resistant epilepsy patients(Springer Heidelberg, 2016) Akdemir, Vedat; Sut, Necdet; Guldiken, BaburhanEpilepsy patients whose seizures cannot be controlled by treatment have a lower quality of life (QoL). The aim of the present study was to compare the potential factors affecting the QoL in patients who were seizure-free with medication or who had drug-resistant epilepsy. The study included 46 drug-resistant and 42 seizure-free epilepsy patients. The demographic and clinical features of the patients were investigated for their effects on patient QoL. The QoL was assessed by the QoL in Epilepsy Inventory-89 and depression was detected by the Beck Depression Inventory. The QoL was significantly lower in the drug-resistant patients than in the seizure-free epilepsy patients (p < 0.001). Depression, lower education level, and unemployment were associated with lower QoL scores (p < 0.001, p < 0.01, p < 0.001, respectively). After adjusting for lower education level and unemployment, depression remained as an independent factor affecting QoL (p < 0.05). In addition to their efforts to control and stop seizures, clinicians should remain aware of depression and treat it effectively to improve the QoL of drug-resistant epilepsy patients.Öğe Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic stroke(Springer, 2009) Guldiken, Baburhan; Sipahi, Tammam; Guldiken, Sibel; Ustundag, Sedat; Budak, Metin; Turgut, Nilda; Ozkan, HulyaThe low plasma nitric oxide concentrations and reduced vascular reactivity are considered major proatherogenic mechanisms in cardiovascular diseases. The present study aimed to assess the allelic frequency and the genotypic distribution of the Glu298Asp gene polymorphism at exon 7 of endothelial nitric oxide synthase (eNOS) gene in Turkish ischemic stroke patients compared to appropriate healthy controls, and to correlate the genetic findings with stroke subtypes. The study population included 146 (75 males, 71 females) patients with ischemic stroke which were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) and 133 (34 males, 99 females) healthy subjects. The eNOS polymorphism was identified with a PCR followed by RFLP with the restriction enzyme BanII. Genotypes were defined as GG, GT, and TT according to the presence of the G and T alleles. In this case-control study, we did not find any significant difference in either the genotypic distribution or allelic frequency of Glu298Asp gene polymorphism between the patients and the controls. In addition, there was also no significant difference for the genotype distribution and the allelic frequency among the stroke subtypes. The results suggested the lack of the association between the Glu298Asp gene polymorphism and ischemic stroke or subtypes of ischemic stroke in the Turkish population.Öğe Hyponatremia Mimicking Transient Global Amnesia(Turkish Neurological Soc, 2017) Kehaya, Sezgin; Guldiken, Baburhan; Dogru, Yuce[Abstract Not Available]Öğe Ictal asystole mimicking seizure deterioration in temporal lobe epilepsy(John Libbey Eurotext Ltd, 2015) Guldiken, Baburhan; Hartl, Elisabeth; Remi, Jan; Noachtar, SoheylWe report on a patient with temporal lobe epilepsy, secondary to a left lateral temporal cavernoma, in whom the change in seizure semiology suggested recurrence of secondary generalized seizures. Anticonvulsive medication previously controlled secondary generalized seizures over a period of years but focal seizures continued at a lower rate. Continuous video-EEG monitoring revealed ictal asystole associated with myoclonic syncope and falls during focal seizures arising from the left temporal lobe. After implantation of a cardiac pacemaker, no more falls occurred during the focal seizures. In conclusion, recurrence of seizure-associated falls is typically attributed to recurrence of secondary generalized seizures, however, ictal asystole should be considered in selected epilepsy patients as a differential diagnosis of falls. [Published with video sequence]Öğe Ictal asystole mimicking seizure deterioration in temporal lobe epilepsy Response(John Libbey Eurotext Ltd, 2016) Guldiken, Baburhan[Abstract Not Available]Öğe Insulin resistance and high sensitivity C-reactive protein in migraine(Cambridge Univ Press, 2008) Guldiken, Baburhan; Guldiken, Sihel; Demir, Muzaffer; Turgut, Nilda; Kabayel, Levent; Ozkan, Hulya; Ozcelik, EmineBackground: A relationship between migraine and vascular disorders such as hypertension, stroke, and coronary ischemia has been recently reported. Insulin resistance and endothelial dysfunction. which commonly underlies these disorders, have not been widely investigated in migraine patients. In this study. we aimed to investigate the existence of insulin resistance and endothelial dysfunction, and their relationship to vascular risk factors in patients with migraine. Methods: We evaluated insulin resistance and high-sensitivity C-reactive protein (hs-CRP), a marker of endothelial dysfunction, in 60 migraine patients and 25 healthy control subjects. Multiple analysis of covariance test was used to adjust for known confounding factors that can influence insulin metabolism and endothelial Function, Such as obesity, blood pressure. and lipid parameters. Results: Insulin resistance, as measured homeostasis model assessment (HOMA)-R levels, was significantly higher in the migraine group (p < 0.001). After adjustment for confounding variables. the relationship between migraine and the HOMA-R levels remained significant (p < 0.001). The hs-CRP levels did not differ between the migraine and control groups. Conclusions: Our data show that insulin resistance is present in migraine patients. Endothelial dysfunction is not found during the headache-free period. Further studies are needed to explain the role of insulin resistance in migraine pathogenesis.Öğe Intraoperative electrical stimulation of the cortex reveals the speech area missed by extraoperative stimulation because of epicortical hematoma(Springer Wien, 2015) Guldiken, Baburhan; Vollmar, Christian; Peraud, Aurelia; Noachtar, Soheyl[Abstract Not Available]Öğe Investigation of the Genetic Etiology in Idiopathic Generalized Epileptic Disorders by Targeted Next-generation Sequencing Technique(Galenos Publ House, 2023) Atli, Engin; Gurkan, Hakan; Guldiken, Baburhan; Eker, Damla; Yalcintepe, Sinem; Demir, Selma; Atli, Emine IkbalBackground: Idiopathic generalized epilepsy is the most common group of epilepsy disorders in children and adolescents. Various types of genetic abnormality were identified among the hereditary factors that explain epilepsy. Aims: To determine the variations in the etiopathogenesis, treatment protocol planning, and prognosis of idiopathic generalized epilepsy using the next-generation sequencing method.Study Design: A cross-sectional study. Methods: This study included 32 patients with idiopathic generalized epilepsy. Genomic DNA was obtained from peripheral venous blood samples taken from the patients. A total of 18 genes encoding ion channel subunits that are involved in monogenic disorders and are associated with idiopathic generalized epilepsy were included. The targeted custom next-generation sequencing panel was designed to cover all coding exons and all exon/intron splice site regions of 18 genes.Results: We detected 9 (28%) variations, including 1 likely pathogenic (a variant in the SCN1A gene) and 8 of unknown clinical significance (2 in the CLCN2 genes, GABBR2, SCN1B, SLC2A1, SLC4A10 genes, and 2 in the TBC1D24 gene).Conclusion: Study results should be supported by functional advanced studies, with increased existing knowledge in the relevant variations.
