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Öğe Childhood trauma and psoriasis, as a psychosomatic disease(Cambridge Univ Press, 2018) Gorgulu, Y.; Cinar, R. Kose; Sonmez, M. B.[Abstract Not Available]Öğe Effects of sertraline on seizure duration during ECT(Cambridge Univ Press, 2018) Aslan, A.; Gorgulu, Y.; Sonmez, M. B.; Cinar, R. Kose[Abstract Not Available]Öğe Elevated neutrophil lymphocyte ratio in patients with substance use disorders(Cambridge Univ Press, 2017) Ozkan, N.; Sonmez, M. B.; Durmus, P. Tas; Gorgulu, Y.; Cinar, R. Kose; Vardar, M. E.[Abstract Not Available]Öğe Evaluation of the cardiovascular disease risk of the psychiatric inpatients of a university hospital by using Framingham risk score(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017) Durmus, P. Tas; Cinar, R. Kose; Sonmez, M. B.; Gorgulu, Y.; Ozkan, N.[Abstract Not Available]Öğe Increased mitochondrial and cytosolic antioxidant enzymes in manic episodes(Elsevier Espana Slu, 2020) Kilic, E. Kahyaci; Cinar, R. Kose; Gorgulu, Y.; Sonmez, M. B.Background and objectives: An increasing number of studies have been conducted to investigate the role of oxidative stress in the pathophysiology of bipolar disorder (BD). The aim of our study was to detect the levels of plasma malondialdehyde and the gene expression of antioxidant enzymes in BD patients during manic period and to assess the changes of these markers during the subsequent remission period. Methods: This study involved 20 drug-free, hospitalized patients with BD type I who met the manic episode diagnostic criteria according to DSM-5, as well as 20 age-sex matched healthy controls. As a marker of lipid damage, malondialdehyde plasma levels were measured by the thiobarbituric acid method; mRNA expression levels of catalase (CAT), glutathione peroxidase (GPx), glutathione synthetase (GS), superoxide dismutase (SOD1) and mitochondrial superoxide dismutase (SOD2) were measured by real-time quantitative PCR from peripheral whole blood samples. Results: In a manic episode, the expression levels of CAT, GPx, GS and SOD2 were higher in the patients than the healthy controls. With treatment, only the GPx levels decreased significantly. The malondialdehyde and SOD1 levels did not differ between the patients and controls, and in the patient group, they did not differ between the mania and remission periods. Conclusion: This is the first study that has assessed the mRNA expression levels of antioxidant enzymes in patients with BD type I. The data from this study suggests that there is an increase in the expression of antioxidant enzymes as a response to oxidative stress in BD, and that the gene expression levels of these antioxidant enzymes could be potential biomarkers for manic phase of the disorder. (C) 2020 Asociacion Universitaria de Zaragoza para el Progreso de la Psiquiatria y la Salud Mental. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Partial empty Sella syndrome and bipolar affective disorder: Two case reports(Cambridge Univ Press, 2018) Basar, E.; Gorgulu, Y.; Cinar, R. K.; Sonmez, M. B.[Abstract Not Available]Öğe Sociotropic personality traits positively correlate with the severity of social anxiety(Sa Medical Assoc Health & Medical Publ Group, 2015) Fistikci, N.; Keyvan, A.; Gorgulu, Y.; Senyuva, G.; Erten, E.; Sungur, M. Z.Aim. To investigate sociotropic-autonomic personality characteristics and their clinical implications in social anxiety disorder (SAD). Methods. The study included 68 consecutive patients who were either being followed up on an outpatient basis or presented for the first time to the psychiatric clinics of Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery or Trakya University School of Medicine between May 2012 and May 2013, and were diagnosed primarily with generalised SAD according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) diagnostic criteria. Beck Depression Inventory (BDI), Sociotropy-Autonomy Scale (SAS), Symptom Checklist-90-R (SCL-90-R), Liebowitz Social Anxiety Scale (LSAS) and a sociodemographic data collection form designed by the authors were used as primary assessment instruments. Results. The mean age (standard deviation (SD)) of the sample group was 23.73 (8.85) years; 37 (54.4%) were female and 31(45.6%) were male. LSAS mean (SD) total fear score was 63.51 (13.74), mean total avoidance score was 61.24 (14.26), BDI mean score was 16.99 (9.58), SAS mean sociotropy score was 71.06 (16.79), and mean autonomy score was 63.22 (16.04). A statistically significant positive correlation was found between SAS sociotropy scores and LSAS fear and avoidance total scores, BDI scores and all subscales of SCL-90-R (p<0.01). There were no statistically significant correlations between SAS autonomy scores and LSAS fear and avoidance total scores, BDI scores and all subscales of SCL-90-R (p>0.05). Conclusion. Sociotropic personality characteristics in patients with SAD have been found to positively correlate with depression and social anxiety levels. Addressing this finding during treatment sessions and helping the patient increase flexibility in appraisal of social life events may have a positive impact on treatment outcome.
