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    The Assessment of the Effect of Changes in Lung Cancer Follow-up Period on the Quality of Life Using EQ-5D Questionnaire and Follow Data (AKAYAK-1 Multicenter Project)
    (Akad Doktorlar Yayinevi, 2018) Erbaycu, Ahmet E.; Goksel, Tuncay; Eser, Erhan; Gursul, Kader K.; Basarik, Burcu; Oz, Aysen; Celik, Pinar
    The EURO-QOL (EQ-5D), a generic quality of life measure, is a self-report scale. The aim was to study the reliability, validity and feasibility of the Turkish version of the EQ-5D as an instrument to evaluate quality of life in lung cancer patients in Turkish society. A prospective cohort study carried out within the framework of the multicenter Lung Cancer Association Project which was conducted in collaboration with Turkish Thoracic Society, Lung and Pleural Malignancies working group and Health and Quality of Life Society. A total of 266 patients were included in the study with a mean age of 61.3 years. 75,9% of the patients had chemotherapy alone; 9% received sequential chemotherapy and radiotherapy, 8,6% were given concurrent chemotherapy and radiotherapy, and 6,4% of them received radical radiotherapy alone. EQ-5D score measures at the moment of diagnosis were found to be moderately reliable while measures at the 3rd chemotherapy cycle, 5th chemotherapy cycle and after the radiotherapy were highly reliable. The items of the EQ-5D were found to be consistent among themselves. EQ-5D Visual Analogue Scale scores at diagnosis, the 3rd cycle, the 5th cycle and following radiotherapy were assessed to be correlated with each other. EQ-5D scale was found to be valid as it meets the conditions of 6 fit indices in our study design. The psychometric properties of the Turkish version of the EQ-5D questionnaire is a valid and reliable scale for patients with lung cancer in Turkey and it can be safely used in clinical practices.
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    The assessment of the effect of changes in lung cancer follow-up period to the quality of life by using EQ-5D questionnaire and follow data (the project of AKAYAK-1)
    (European Respiratory Soc Journals Ltd, 2013) Gursul, Kader Kiyar; Erbaycu, Ahmet Emin; Goksel, Tuncay; Eser, Erhan; Basarik, Burcu; Oz, Aysen; Celik, Pinar
    [Abstract Not Available]
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    Comparison of different generic and lung cancer specific quality of life instruments for their predictive ability of survival in patients with advanced lung cancer
    (Springer, 2014) Eser, Sultan; Goksel, Tuncay; Erbaycu, Ahmet Emin; Eser, Erhan; Basarik, Burcu; Oz, Aysen; Gursul, Kader Kiyar
    [Abstract Not Available]
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    Comparison of generic and lung cancer-specific quality of life instruments for predictive ability of survival in patients with advanced lung cancer
    (Springer International Publishing Ag, 2016) Eser, Sultan; Goksel, Tuncay; Erbaycu, Ahmet Emin; Baydur, Hakan; Basarik, Burcu; Yanik, Aysen Oz; Gursul, Kader Kiyar
    Background: Our purpose is to examine the relationship of Health related quality of life measured by EORTC QLQc30, QLQ-LC13; FACT-L, LCSS, Eq5D) with survival in advanced lung cancer patients. A total of 299 Lung Cancer (LC) patients were, included in this national multicenter Project entitled of the LC Quality of Life Project (AKAYAK). Baseline scores were analyzed by using Cox's proportional hazard regression to identify factors that influenced survival. Univariate and multivariate models were run for each of the scales included in the study. Results: Mean and median survival were 12.5 and 8.0 months respectively. Clinical stage (as TNM), comorbidity; symptom scales of fatigue, insomnia, appetit loss and constipation were associated with survival after adjustment for age and sex. Global, physical and role functioning scales of QLQc30; physical and functional scales of LCS and TOI of the FACT-L was also associated with survival. Mobility and Usual activities dimensions of the Eq5D; Physical functioning and the constipation symptom scale of the QLQ-c30; and LCS and TOI scores of the FACT-L remained statistically significant after adjustment. LC13 and LCSS scales were not predictors of survival. Conclusions: HRQOL serves as an additional predictive factor for survival that supplements traditional clinical factors. Besides the strong predictive ability of ECOG on survival, FACT-L and the Eq5D are the most promising HRQOL instruments for this purpose.
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    The effect of changes in quality of life in patients with lung cancer in the observation period (European Organization for Research and treatment of Cancer) EORTC QLQ-C 30 results of the evaluation and follow-up (AKAYAK-1 project)
    (European Respiratory Soc Journals Ltd, 2013) Oz, Aysen; Celik, Pinar; Goksel, Tuncay; Erbaycu, Ahmet Emin; Eser, Erhan; Basarik, Burcu; Gursul, Kader Kiyar
    [Abstract Not Available]
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    FACT-L (functional assessment of cancer therapy-lung) psychometric properties of the Turkish version of quality of life scale (validity and reliability) and determination using the clinic (Akkaya-1 project)
    (European Respiratory Soc Journals Ltd, 2013) Basarik, Burcu; Goksel, Tuncay; Erbaycu, Ahmet Emin; Eser, Erhan; Oz, Aysen; Celik, Pinar; Gursul, Kader Kiyar
    [Abstract Not Available]
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    The Psychometric Properties and Clinical Use of the Turkish Version of the Functional Assessment of Cancer Therapy-Lung (FACT-L) Scale
    (Aves Press Ltd, 2019) Aydogan, Burcu Basarik; Goksel, Tuncay; Erbaycu, Ahmet Emin; Oz, Aysen; Celik, Pinar; Gursul, Kader Kiyar; Edis, Ebru Cakir
    Objectives:psychometric properties of the Turkish version of the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale and the sensitivity to changes in clinical indicators. Patients and Methods:This study was conducted within the framework of a national multicentre project. Patients with either stage IIIB or IV primary lung cancer diagnosed after April 2010were included in thisstudy. A classical confirmatory approach was used for both the reliability and validity analyses. Internal consistency was tested using Cronbach's alpha value, and the validity analysis was performed using construct validity and clinical validity. Results:276 (92.3%) patients were male and the average age was 60.8 +/- 9.4 years. The most frequently observed histological type was squamous cell carcinoma (36.8%), and 61.5% of these stage IV tumours. Cronbachs alpha values for the subscales ranged from 0.60 to 0.84. The majority of the FACT-L subscales revealed inter-scale correlation coefficients greater than 0.35. All sub-dimensions, except that of the social/family well-being scale, are able to significantly discriminate between stages IIIB and IV. Significantly lower scale scores were detected in patients with stage IV than stage IIIB. The comparative fit index was 0.917, and the root mean square error of approximation was 0.091. Dyspnoea, haemoptysis, chest pain, weight loss, anorexia, localised pain, and fever symptoms had a significant correlation with the FACT-L, trial outcome index, and lung cancer subscale. Conclusion:Turkish version of the psychometric properties of the original FACT-L scale is regarded as a valid and reliable tool and can be used safely in a clinical context when managing patients with lung cancer in Turkey.