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Öğe Hepatitis e virus epidemiology in adult population in edirne province, Turkey(2009) Eker A.; Tansel O.; Kunduracilar H.; Tokuç B.; Yulu?kural Z.; Yüksel P.Hepatitis E virus (HEV) clinical presentations range from asymptomatic infection to fulminant hepatitis which is frequently seen in pregnant women. Epidemics due to HEV mostly originate from contaminated water and the virus is transmitted by fecal oral way. Its frequency is closely related to the socioeconomical status of the community. The aim of this first community-based study performed in Edirne province (located at Trace region of Turkey) was to determine the seroprevalence of HEV and the risk factors in the city center. Five hundred eighty two people (273 men, 309 women) over age 15 years, representing the population of Edirne city center were included in the study. Anti-HEY lgG antibodies were investigated in the serum samples by ELISA method. Anti-HEV antibodies were detected in a total of 14 cases (11 women, 3 men) and HEV infection prevalence was found to be 2.4%. The mean age of seropositive people was 50.86 ± 16.76 years while it was 40.7 ± 16.9 years in seronegative people (p= 0.027). This result was attributed to the better water supply and sanitation conditions in Edirne province in comparison to other parts of Turkey and shift of HEV seropositivity in older ages. No statistically significant difference was detected between seropositive and seronegative cases in terms of socioeconomical conditions, both groups being in high socioeconomical level. The analysis of the risk factors revealed that the rate of people living in houses built with materials other than reinforced concrete (p= 0.044), dealing with stockbreeding (p= 0.046) and consuming fruits and vegetables without proper washing (p= 0.015) were significantly higher in the seropositive group. No statistically significant difference was detected for the other risk factors such as the number of household, presence of city water supply and sewage system in the house, location of the water closet outside house, lack of hand-washing habits, sharing utensils, consumption of raw vegetables, history of blood transfusion, surgery, dental intervention, jaundice, contact with a case of hepatitis, abortion/stillbirth and suspicious sexual contact. While the HEV seropositivity rate (2.4%) detected in Edirne was lower than the average of Turkey (6%), it was similar to the results reported from western part of the country. High rates of seropositivity among people with individual incompatibility to the hygiene rules denotes that personal hygiene is an important factor for prevention from HEV infection. High rate of seropositivity among people dealing with stockbreeding also suggests that there may be different ways of HEV transmission other than contaminated water in sporadic cases.Öğe Mycoplasma pneumoniae pneumonia presenting with febrile neutropenia(2007) Celik A.D.; Eker A.; Yukugkural Z.; Kuloglu F.; Tansel O.; Akata F.; Tugrul M.A case of Mycoplasma pneumoniae pneumonia presenting with severe neutropenia, and diagnosed by immunoflourecence test is reported here. The patient was admitted to our clinic with severe neutropenia, and fever. During follow up a pneumonic consolidation was detected by thorax computerized tomography (CT) and anti-IgM was positive for M. pneumoniae serologically. It was concluded that neutropenia can develop due to M. pneumoniae. © 2007 Elsevier Ltd. All rights reserved.Öğe Seroepidemiology of toxoplasmosis and the theoretical incidence of congenital toxoplasmosis in women of reproductive age in Edirne, Turkey. A community based study(Turkiye Klinikleri, 2009) Tansel Ö.; Ekuklu G.; Kunduracilar H.; Eker A.; Yulu?kural Z.; Yüksel P.Objective: The aims of this community-based study were to determine the seroprevalence of toxoplasmosis in women of reproductive age, to identify the risk factors, and to estimate theoretical incidence of congenital toxoplasmosis in Edirne city center. Material and Methods: Sera from 96 women representing the female population in the city center were tested for toxoplasma IgG antibody using the ELISA technique. For each participant, a questionnaire was completed to provide information on socio-demographic data, obstetrical history, and life style parameters. The relation between toxoplasma positivity and probable risk factors was investigated with chi-square and independent samples t test during statistical analysis. Results: The ages of the study population ranged from 15 to 49 years with a mean age of 31.2 years. 33 (34.4 %) of 96 women were positive for toxoplasma IgG antibody. The mean age of women with seropositive samples was 34.2 ± 10.4 years. The mean age of seronegative women was 29.7 ± 9.2 years. Although the mean age was higher in seropositive women when compared with seronegative, the rates of seropositivity were not significantly different between age groups (p= 0.246). Toxoplasma seropositivity was 85.7% for women with high income and 100% for women with low income. This difference was statistically significant (p= 0.025). The other risk factors were not significantly different between seropositive and seronegative cases. The mean theoretical incidence of congenital toxoplasmosis was 0.7% in our study and it decreased from 1.3% to 0.2% as the person aged. Conclusion: Approximately two out of every three reproductive age women in Edirne city center is at risk of toxoplasmosis. The risk of congenital toxoplasmosis is higher for babies of women aged 15-24 years. These results underline the necessity of promoting preventive measures for toxoplasmosis in reproductive age women. Copyright © 2009 by Türkiye Klinikleri.