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    Assessment of cardiovascular risk for serious mental disorders
    (Klinik Psikiyatri Dergisi, 2019) Cinar, Rugul Kose; Durmus, Pelin Tas
    Objective: Incidence and prevalence of cardiovascular diseases in patients with severe mental disorders are higher than the general population. It was aimed to calculate the 10 year cardiovascular disease risk by using Framingham risk scoring (FRS) and investigate the relationship between this score and C-reactive protein in psychiatric inpatients of a university hospital. Method: Inpatients with the diagnosis of major depression, bipolar disorders and psychotic disorders in six months time were included in the study.Participants were assessed based on their gender, age, body mass index, waist circumference, FRS, and CRP levels. Results: The calculated 10 year cardiovascular disease development risk did not differ between the diagnosis (p=0,39), but found to be significantly higher in males than females (p=0,002). FRS levels showed positive correlations with male gender (p=0,002), age (p=0,000), waist circumference (p=0,001), and body mass index (p=0,001). Discussion: We have to evaluate coexisting somatic diseases of psychiatric patients as well as behavioral and psychological problems. Using FRS, evaluating body mass index and waist circumference could help us predict the risky population and we could consider our drug treatment choices accordingly.
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    Evaluation of the Effects of High Intensity Interval Training on Cytokine Levels and Clinical Course in Treatment of Opioid Use Disorder
    (Turkiye Sinir Ve Ruh Sagligi Dernegi, 2020) Durmus, Pelin Tas; Vardar, Mehmet Erdal; Kaya, Oktay; Tayfur, Pinar; Sut, Necdet; Vardar, Selma Arzu
    Objective: Opioid use disorder (OpUD) is a biological and psychosocial disorder with limited treatment options. Addition of physical exercise to the pharmacological treatment has been proposed to be effective on reducing substance use and improving the quality of life. In this study we aimed to investigate the effects of a high-intensity interval training (HIIT) program on the serum levels of cortisol, insulin-like growth factor1 (IGF-1), interferon-gamma (IFN-gamma), interleukin 17 (IL-17) and the clinical progress of inpatients with OpUD. Method: Our study enrolled 22 male inpatients diagnosed with OpUD on the basis of the DSM-5 criteria. Two groups of 11 individuals were formed as the exercise (EG) and the control (CG) groups. The EG conducted 5 sessions of a HIIT. Participant data were collected with Sociodemographic Questionnaire, the Addiction Profile Index (API), and the Barratt Impulsiveness Scale (BIS-11). Also, the Hamilton Depression Rating Scale (HAM-D), the Hamilton Anxiety Rating Scale (HAM-A) and the Substance Craving Scale (SCS) were used before and after the treatment program in order to evaluate the clinical progress. Blood samples were collected on the 5th and the 21st days for estimation of the serum cortisol, IGF-1, IFN-gamma and the IL-17 levels. Results: Comparison of the pre- and the post-treatment performances of the two groups on the HAM-D, the HAM-A and the SCS indicated a significant drop in the respective scores of the EG. Also, a significant increase was observed in the post-treatment IGF-1 level of the EG as compared to the CG. No differences were observed between the cortisol, IFN-gamma and IL-17 levels of the EG and the CG. Conclusion: HIIT resulted in significant reduction in the symptoms of depression, anxiety and substance craving, and increased the serum IGF-1 levels. HIIT did not change serum cortisol, IFN-gamma and IL-17 levels. We believe this research will contribute to the literature on the treatment of opioid depencence by emphasising the effects of HIIT on patients treated for OpUD.
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    Late-onset clozapine-induced neutropenia treated with lithium
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2019) Durmus, Pelin Tas; Gorgulu, Yasemin; Sonmez, Mehmet Bulent; Cinar, Rugul Kose
    Clozapine is a second-generation antipsychotic drug, proven to be effective in treatment-resistant schizophrenia. Among patients using clozapine; the incidence of neutropenia is approximately 3% and the incidence of agranulocytosis is approximately 1%. This side effect is diminishing after 18 weeks of drug initiation. Here, we present a case of clozapine-induced neutropenia in a schizophrenic patient seen after 7 years of clozapine use and its treatment with lithium supplementation.
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    Perceived occupational competence and value among university students with premenstrual dysphoric disorder
    (Sage Publications Ltd, 2022) Pekcetin, Serkan; Ozdinc, Sevgi; Ata, Hilal; Can, Hilal Basak; Aydin, Nimet Sermenli; Durmus, Pelin Tas; Caliyurt, Okan
    Introduction Premenstrual dysphoric disorder (PMDD) is defined as a mental health issue and is assessed using DSM-V diagnostic criteria. Premenstrual dysphoric disorder comprises emotional, behavioral, and physical symptoms that occur in the premenstrual phase and resolve shortly after the start of menstruation. These symptoms and functional impairment may negatively affect occupational competence and value. This study investigated perceived occupational competence and value in university students with premenstrual dysphoric disorder. Methods This cross-sectional study was performed at a public university with 35 students with PMDD and 35 age-matched students without PMDD. Occupational competence and value were evaluated using the Occupational Self-Assessment (OSA). Results There was a significant difference between the groups in OSA competence score (p < 0.05), while there was no significant difference in OSA value score (p > 0.05). Conclusion This study demonstrated that university students with PMDD experience more occupational competence challenges than peers without PMDD. Further studies should be performed to determine the role of occupational therapy in the rehabilitation of PMDD.