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Öğe ARE CLINICAL FEATURES IN LOFGREN'S SYNDROME-RELATED ERYTHEMA NODOSUM DIFFERENT FROM IDIOPATHIC ERYTHEMA NODOSUM?(Mattioli 1885, 2012) Donmez, S.; Kisacik, B.; Pamuk, O. N.; Pehlivan, Y.; Aydogdu, E.; Yurekli, O. A.; Onat, A. M.Background and Objectives: We retrospectively evaluated acute sarcoidosis (Lofgren's syndrome) patients diagnosed at 2 centers and compared the clinical features of Lofgren's syndrome (LS) related erythema nodosum (EN) to patients with idiopathic IEN who were diagnosed within the same time frame. Methods: Thirty patients (10 males, 20 females) who were diagnosed with LS and were being followed up for the last 8 years at 2 centers were included. Thirty patients (4 males, 26 females) who were admitted to the rheumatology outpatient clinics for IEN during that time period were taken as controls. The clinical and laboratory features at the initial admission, treatment modalities and response were recorded. Results: Twentyfour (80%) patients with LS related EN had arthritis and/or arthralgia. Fifteen of them had only findings of periarticular ankle inflammation and 4 had polyarthritis. When LS related EN patients were compared to IEN patients, the former group had more arthritis and/or arthralgia (p<0.001), leucocytosis (p=0.02), lymphopenia (p=0.005) and thrombocytosis (p=0.05), and higher ESR (p=0.02). Twentyfive (83.3%) patients with LS related EN were administered oral corticosteroids. In 21 patients, hilar lymphadenopathy disappeared on control chest x-ray and CT; in 3 patients, minimal residual lymph node enlargement was persistent. During a median follow-up of 54 months (range: 10-84 months), none of the LS related EN patients had clinical relapse. Conclusions: Apart from BHL, arthritis and/or arthralgia especially periarticular ankle inflammation is the feature which could be used to differentiate LS related EN from IEN. There is more need for steroids in LS patients and the symptoms quickly resolve with steroids.Öğe THE ASSOCIATION BETWEEN TYPE I INTERFERON RESPONSE, COMPLEMENT ACTIVATION AND CLINICAL FINDINGS IN SYSTEMIC LUPUS ERYTHEMATOSUS(Bmj Publishing Group, 2014) Sacar, K.; Pamuk, O. N.; Pamuk, G. E.; Uyanik, M. S.; Donmez, S.[Abstract Not Available]Öğe The association between type I Interferon Response, complement activation and clinical findings in Systemic Lupus Erythematosus(Clinical & Exper Rheumatology, 2015) Sacar, K.; Pamuk, O. N.; Pamuk, G. E.; Uyanik, M. S.; Donmez, S.[Abstract Not Available]Öğe Autoimmune rheumatic disease associated symptoms in fibromyalgia patients and their influence on anxiety, depression and somatisation: a comparative study(Clinical & Exper Rheumatology, 2012) Donmez, S.; Pamuk, O. N.; Umit, E. G.; Top, M. S.Objective. In this study we evaluated the frequency of autoimmune rheunzatic disease associated major symptoms in fibromyalgia (FM) patients, and the association between their presence and anxiety, depression and somatisation. Methods. Two hundred and thirty-two FM, 78 systemic lupus erythematosus (SLE) patients and 70 healthy controls were included. All subjects were questioned face-to-face for the presence of autoimmune rheumatic disease-associated symptoms and antinuclear antibody (ANA) was determined. All FM patients were questioned for the severity of pain and symptoms of FM by using a visual analogue scale. In addition, all subjects were interrogated for anxiety, depression, somatic symptoms and neuropathic pain by using different validated questionnaires. Results. FM patients had significantly higher frequency of photosensitivity (27.6% vs. 11.4%) and Raynaud phenomenon (22% vs. 10%) when compared to controls (p-values, 0.005 and 0.026). FM patients had significantly lower frequencies of photosensitivity, oral ulcers, xerostomia, and xerophthalmia than SLE patients (all p-values <0.001). ANA positivity was 11.8% in FM patients and 7.1% in healthy controls. ANA-positive and negative FM patients had similar frequencies of autoimmune rheumatic disease symptoms. FM patients with photosensitivity had higher anxiety (p=0.002), somatic symptoms (p=0.015) and neuropathic pain (p=0.03) scores than others. FM patients with Raynaud had higher anxiety (p=0.004), depression (p=0.001), somatic symptom (p<0.001) and neuropathic pain scores than others. Conclusion. The presence of which findings in FM seems to be associated with anxiety, depression, and somatisation rather than ANA positivity and disease severity.Öğe THE EPIDEMIOLOGICAL AND CLINICAL FEATURES OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS FOLLOWED UP AT A SINGLE CENTER IN NORTHWESTERN TURKEY(Bmj Publishing Group, 2015) Pamuk, O. N.; Balci, M. A.; Donmez, S.; Pamuk, G. E.[Abstract Not Available]Öğe EPIDEMIOLOGY AND OUTCOME OF ADULT-ONSET STILL'S DISEASE IN NORTHWESTERN THRACE REGION IN TURKEY(Bmj Publishing Group, 2015) Balci, M. A.; Pamuk, O. N.; Pamuk, G. E.; Uzundere, F. K.; Donmez, S.[Abstract Not Available]Öğe Epidemiology and outcome of adult-onset Still's disease in the Northwestern Thrace region in Turkey(Clinical & Exper Rheumatology, 2015) Balci, M. A.; Pamuk, O. N.; Pamuk, G. E.; Uzundere, F. K.; Donmez, S.Objective Adult-onset Still's disease (AOSD) is a rare disease that is classified among the multifactorial autoinflammatory disorders. It is characterised by fever, arthritis and, a typical salmon-coloured rash, and is accompanied by fever at nights. Currently, there is limited data on the prevalence of AOSD. Methods Patients diagnosed with AOSD at the Department of Rheumatology of Trakya University Medical Faculty, between 2003 to 2014 were reviewed retrospectively. Patients' clinical features, laboratory measurements, demographics, treatments, follow-up durations, disease courses, outcomes and complications were evaluated. Results Our study included 42 patients with AOSD of whom, 32 (76.2%) were females and 10 (23.8%) were males (female to male ratio: 3.2). Over the course of the study, the annual incidence of AOSD was 0.62/100,000; and the overall prevalence was 6.77/100,000. The most common findings were fever (97.6%), arthralgia (95.2%), arthritis (76.2%), rash (73.8%) and sore throat (40.5%). Conclusion In our hospital-based study on AOSD which is a disease with very limited epidemiological data, the frequency of AOSD was found to be significantly higher than in other series. Female gender was more common in our series; and polycyclic pattern was more common in patients with longer follow-ups.Öğe EPIDEMIOLOGY AND OUTCOME OF DERMATOMYOSITIS IN NORTHWESTERN THRACE REGION IN TURKEY(Bmj Publishing Group, 2016) Balci, M. A.; Saritas, F.; Donmez, S.; Pamuk, O. N.[Abstract Not Available]Öğe THE EPIDEMIOLOGY OF TAKAYASU ARTERITIS: A HOSPITAL-BASED STUDY FROM NORTHWESTERN PART OF TURKEY(Bmj Publishing Group, 2015) Saritas, F.; Pamuk, O. N.; Donmez, S.[Abstract Not Available]Öğe Giant cell arteritis and polymyalgia rheumatica in northwestern Turkey: Clinical features and epidemiological data(Clinical & Exper Rheumatology, 2009) Pamuk, O. N.; Donmez, S.; Karahan, B.; Pamuk, G. E.; Cakir, N.Objective. In this study, we evaluated clinical and epidemiologic features of our giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) patients. Methods. Me retrospectively recorded down the general features of patients with GCA and PMR diagnosed at our center within the last 6 years. The incidence rates per 100000 aged. >= 50 were calculated. In addition, we reported the frequencies of GCA/PMR in our previous epidemiologic study. Results. Nineteen patients were diagnosed with GCA (10F, 9M) and 53 with isolated PMR (39F 14M). The annual incidence for GCA in subjects >= 50 years old was 1.13/100000, and for PMR it was 3.15/100000. The incidence of GCA and PMR in females were, respectively, 1.14/100000 and 4.48/100000. In males, the incidences of GCA and PMR were, respectively, calculated as 1.1/100000 and 1.72/100000. In our population-based study, the prevalences of GCA and PMR (>= 50 ages) were estimated as 20/100000. Fourteen (73.7%) GCA patients had symptoms of PMR. Two patients had developed unilateral and one patient bilateral permanent visual loss. Initial ESR was lower than 40 mm/hr in one GCA patient (5.3%) and in 6 PMR patients (11.3%). The median duration of follow-up(l) was 16 months in GCA; and 8 months in PMR patients. One patient with PMR and another patient with GCA had lung cancer. One PMR patient had myelodysplastic syndrome. During follow-up, 4 patients with GCA died. Conclusions. Me detected a lower frequency GCA/PMR in our center in northwestern Turkey than in Scandinavian and southern European countries.Öğe The incidence and prevalence of systemic lupus erythematosus in Thrace, 2003-2014: A 12-year epidemiological study(Sage Publications Ltd, 2016) Pamuk, O. N.; Balci, M. A.; Donmez, S.; Tsokos, G. C.Background We estimated the prevalence and incidence, clinical features, treatment, and prognosis of systemic lupus erythematosus (SLE) patients in the Thrace region of Turkey. Methods We retrospectively evaluated 331 patients (307 female, 24 male, mean age 38.5 years) diagnosed with SLE between 2003 and 2014. Clinical features, treatments, and response to various treatment modalities were recorded. Our hospital has been the only tertiary referral center for rheumatological diseases for a mixed rural and urban population of 620,477 people (306,036 females, 314,411 males) for more than 16 years. Results The mean annual incidence of SLE was 4.44/100,000 (females, 8.4/100,000; males, 0.6/100,000). The overall prevalence of SLE was 51.7/100,000 (females, 97.7/100,000; males, 7/100,000). Major organ involvement was present in the following percentages: neurologic involvement: 20.1%; renal involvement: 28.2%; autoimmune hemolytic anemia: 9.6%; thrombocytopenia: 14.7%. Seventeeen SLE patients (13 females, four males) died at a median follow-up of 48 months. The five-year survival was 94.5%, and the ten-year survival was 89.9%. According to Kaplan-Meier survival analysis, poor prognostic factors were: male gender (p=0.015); smoking (p=0.02); pleural involvement (p=0.011); thrombocytopenia (p=0.021); myocarditis (p=0.028); renal involvement (p=0.037); treatment with cyclophosphamide (p=0.011); and an initial high SLEDAI score (>4) (p=0.02). Lymphopenia at the time of diagnosis appeared as a favorable prognostic factor (p=0.008). Cox regression analysis revealed myocarditis (OR: 20.4, p=0.018) and age at diagnosis (OR: 1.11, p=0.035) to be poor, and lymphopenia at the time of diagnosis to be good prognostic factors (OR:0.13, p=0.031). Conclusions The annual incidence and prevalence of SLE in the Thrace region of Turkey is lower than those reported in North America, however they are similar to those reported for European countries. Clinical manifestations appear to be milder, whereas survival was similar to those recorded in Western countries.Öğe THE INCIDENCES OF ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN NORTHEASTERN PART OF TURKEY(Bmj Publishing Group, 2013) Pamuk, O.; Donmez, S.; Calayir, G. B.[Abstract Not Available]Öğe INCREASED OXIDATIVE DNA DAMAGE AND IMPAIRED GENE REPAIRING PATHWAY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS(Bmj Publishing Group, 2016) Donmez, S.; Pamuk, G. E.; Doganlar, O.; Pamuk, O. N.[Abstract Not Available]Öğe INVESTIGATING THE ASSOCIATION BETWEEN RHO-KINASE 1 (ROCK1) GENE POLYMORPHISMS AND SYSTEMIC SCLEROSIS(Bmj Publishing Group, 2013) Pehlivan, Y.; Oztuzcu, S.; Donmez, S.; Alibaz-Oner, F.; Cetin, G. Yildirim; Yolbas, S.; Bozgeyik, I.[Abstract Not Available]Öğe INVESTIGATION OF FEAR AVOIDANCE BELIEFS IN ANKYLOSING SPONDYLITIS PATIENTS(Bmj Publishing Group, 2016) Ozen, T.; Donmez, S.; Pamuk, O. N.; Balci, M. A.; Ozdinc, S.[Abstract Not Available]Öğe PARANEOPLASTIC ARTHRITIS: A MULTI-CENTERED EXPERIENCE(Bmj Publishing Group, 2013) Kisacik, B.; Onat, A. M.; Kasifoglu, T.; Pehlivan, Y.; Pamuk, O. N.; Dalkilic, E.; Donmez, S.[Abstract Not Available]Öğe The results of purified protein derivative test in ankylosing spondylitis patients(B M J Publishing Group, 2007) Pamuk, Oe. N.; Yesil, Y.; Donmez, S.; Uenlue, E.; Cakir, N.[Abstract Not Available]Öğe SECONDARY AMYLOIDOSIS IN ANKYLOSING SPONDYLITIS AND THE ROLE OF ANTI-TNF THERAPY(Clinical & Exper Rheumatology, 2012) Donmez, S.; Pamuk, O. N.; Pamuk, G. E.; Aydogdu, E.; Inman, R.[Abstract Not Available]Öğe TREATMENT SATISFACTION WITH TUMOUR NECROSIS FACTOR-ALPHA INHIBITORS (ANTI-TNF) IN ANKYLOSING SPONDYLITIS(Bmj Publishing Group, 2015) Oksuzi, M. F.; Balci, M. A.; Tufan, A. N.; Sahin, A. B.; Gocken, A.; Durmus, Y.; Donmez, S.[Abstract Not Available]Öğe Validity and reliability of the Lupus QoL index in Turkish systemic lupus erythematosus patients(Sage Publications Ltd, 2015) Pamuk, O. N.; Onat, A. M.; Donmez, S.; Mengus, C.; Kisacik, B.Background Systemic lupus erythematosus (SLE) patients have seriously impaired quality of life (QoL). In addition to activity and damage indices used in the past, tools to evaluate QoL in SLE have been developed in recent years. In this study, we test the validity of the Turkish version of the Lupus-QoL (LupusQoL-TR) score, and investigate its association with clinical findings and activity indices. Methods A total of 132 patients diagnosed with SLE according to ACR 1997 criteria were included. The clinical and demographic features, and biochemical data were retrieved from hospital records. SLE Disease Activity Index (SLEDAI) and damage score (SLICC-ACR) were determined at the time of administration of Lupus-QoL questionnaire. The Lupus-QoL includes 34 questions divided into eight domains. We reevaluated the LupusQoL-TR and pretested its understandability. SLE patients were concomitantly administered the LupusQoL-TR and generic SF-36. Internal consistency, test-retest reliability, convergent and discriminant validity were calculated. Results The mean age of our SLE patients was 37.912.8 years. Internal consistency reliability ranged from 0.88 to 0.93, and test-retest reliability from 0.84 to 0.94. LupusQoL-related domains in SF-36 were correlated (from 0.66 to 0.74). Most LupusQoL-TR domains, except planning, were able to discriminate between active and inactive SLE groups. Scores in all domains of the LupusQoL-TR were found to be discriminative for patients with and without damage according to SLICC-ACR score. Conclusion The LupusQoL-TR was found to be a valid patient-reported outcome measure method when evaluating QoL in Turkish SLE patients.
