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    Comparison of preoperative magnetic resonance imaging results with postoperative pathologic results in early stage uterine cervical cancer
    (I R O G Canada, Inc, 2018) Dolgun, Z. N.; Altintas, A. S.; Ivan, C.; Balkanli, P.
    Objective: To compare the preoperative magnetic resonance imaging (MRI) findings of early stage cervical cancer patients with their postoperative hystopathologic results. Materials and Methods: This is a retrospective study evaluating oncology charts of 30 early-stage cervical carcinoma patients who were diagnosed and underwent surgery between July 2006 to August 2011 at the present institution. Preoperative MRI staging, clinical staging, and histopathologic staging results were compared. Results: Seven patients had clinically correct stage and 20 patients had correct MRI staging according to histopathology. MRI staging revealed 66% sensitivity and it was strongly correlated with pathologic staging. Cervical ring invasion was present in 20 patients pathologically, whereas 13 patients were diagnosed positive on MRI evaluation. Among ten patients without cervical ring invasion, MRI diagnosed six of them correctly. Of the 11 positive parametrial invasion patients diagnosed pathologically, MRI ruled out only seven of them. Conclusion: Preoperative MRI staging might be a better tool to stage cervical cancer than clinical staging. MRI evaluates parametrial invasion and cervical ring involvement appropriately.
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    Is there A Relationship between Route of Delivery, Perinatal Characteristics, and Neonatal Outcome in Preterm Birth?
    (Wolters Kluwer Medknow Publications, 2018) Dolgun, Z. N.; Inan, C.; Altintas, A. S.; Okten, S. B.; Karadag, C.; Sayin, N. C.
    Background: Preterm birth is one of the most challenging problems in obstetric care and it is closely related to perinatal mortality and morbidity. The aim of the current study was to document our experience with preterm births and to analyze the association between perinatal variables and clinical outcomes. Methodology: In this retrospective study, data were derived from the medical records of 785 singleton preterm births delivered in the obstetrics and gynecology department of our institution. Variables under investigation were maternal and gestational ages, fetal gender, route of delivery (vaginal vs. cesarean section [C/S]), causes of preterm birth, birth weight, placental weight, umbilical cord length, and Apgar scores at the 1st and 5th min. Results: Pregnant women with advanced age (>= 35 years) were more likely to undergo C/S (P < 0.001). Apgar score at the 1st and 5th min was influenced significantly by gestational age (P < 0.001), newborn birth weight (P < 0.001), placental weight (P < 0.001), and umbilical cord length (P < 0.001). Infants delivered due to antepartum fetal distress indication had remarkably lower Apgar scores at the 1st min and the birth weight seemed to be positively correlated with Apgar scores at both 1st (P < 0.001) and 5th min (P < 0.001). Apgar scores both at the 1st and 5th min were positively correlated with placental weight (R: 0.239 and 0.231, respectively, and P < 0.001 for both) and length of umbilical cord (R: 0.228 and 0.211, respectively, and P < 0.001 for both). Conclusion: Advanced age pregnancies have higher C/S rates, but Apgar scores are significantly correlated with infant characteristics. Umbilical cord length and placental weight might be the new add-on predictors of postpartum well-being in premature infants.
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    Obstetric outcomes of recurrent pregnancy loss patients diagnosed with inherited thrombophilia
    (Springer London Ltd, 2017) Karadag, C.; Yoldemir, T.; Karadag, S. D.; Inan, C.; Dolgun, Z. N.; Aslanova, L.
    Background Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies. The relation between RPL and inherited thrombophilia requires anticoagulant therapy during pregnancy. However the obstetric outcomes have not been well defined in these RPL patients diagnosed with inherited thrombophilia, who have been given anticoagulant therapy. Aim To investigate the obstetric outcomes in pregnant women with RPL who are given low molecular weight heparin (LMWH) and low-dose aspirin due to diagnosis of inherited thrombophilia. Methods A hundred and eight RPL women were diagnosed with inherited thrombophilia, and 98 women were diagnosed with unexplained RPL. The patients with inherited thrombophilia were given LMWH and low-dose aspirin. Unexplained RPL patients were not given any medicine. The obstetric outcomes of participants were noted. Results In thrombophilic group, the live-birth levels were significantly higher [90 (83%) vs 67 (68%) p < 0.05], and the miscarriage levels were significantly lower than that in the control group [14 (13%) vs 27 (28%) p < 0.01]. The number of patients with preeclampsia was significantly higher in the thrombophilic group [16 (15%) vs 6 (6%) p < 0.05]. The number of preterm births was significantly higher than that of the controls [25 (23%) vs 10 (10%) p < 0.05]. The median gestation age of delivery was 35 weeks for thrombophilic patients and 38 weeks for controls (p < 0.05). Conclusion The RPL patients diagnosed with inherited thrombophilia and who were given LMWH with low-dose aspirin had higher live-birth rates and lower miscarriage rates than those in the unexplained RPL patients. Increased risk of preeclampsia is seen in RPL patients with inherited thrombophilia despite thrombophilia prophylaxis.