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Öğe The determination of interaction between naringin and different chemotherapy agents in neuroblastoma and astrocyte cell lines(Wiley, 2017) Turker, N. P.; Doganlar, Z. B.[Abstract Not Available]Öğe Different responses of apoptotic, inflammatory and heat shock protein gene expression to a single bout of high-intensity interval exercise between physically active and inactive men(Canadian Science Publishing, 2021) Vardar, S. A.; Doganlar, Z. B.; Kaya, O.; Tayfur, P.; Sut, N.; Doganlar, O.High mechanical load of muscles may induce muscular apoptosis on the one hand and adaptation to exercise on the other. This study aimed to explore whether changes of circulatory levels of inflammation, apoptosis and heat shock proteins (HSPs) messenger RNA (mRNA) following single bout of high-intensity interval exercise (HIIE) differs between physically active (PA) and inactive (PI) men. Nine PA and 9 PI (peak oxygen consumption: 2.6 +/- 0.4 vs. 2.0 +/- 0.2 L.min(-1)) healthy men (age: 28.7 +/- 6.3 vs. 30.2 +/- 4.5 years and body mass index: 2.6 +/- 2.1 vs. 23.3 +/- 2.8 kg.m(-2)) performed HIIE, comprising 4 repeats of a Wingate test (load: 0.050 kg.kg(-1) body weight). Blood samples were collected before exercise, 5 min after HIIE, and 24 h after HIIE for measuring mRNA of inflammation markers interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha), apoptosis markers including Bcl-2, Bax, and HSP27, HSP60, HSP70, HSP90 using quantitative real-time PCR analysis. Post-HIIE IL-6, TNF alpha and HSP60 were higher in the PI than the PA group 5 min after exercise (p = 0.003, effect size (ES) = 1.59; p = 0.007, ES = 1.59 and p = 0.027, ES = 1.10 respectively). HSP70 acutely increased only in the PA group (p = 0.024, ES = 1.20). The increase in Bcl-2 (p = 0.047, ES = 1.08) and Bax (p = 0.024, ES = 1.20) levels were higher in the PI group 5 min after HIIE. The present study indicated that the response of inflammatory, apoptosis and HSP gene expressions to HIIE in blood of healthy male volunteers strongly depends on their level of regular physical activity. Novelty: Blood IL-6 and HSP60 mRNA levels following high intensity exercise may indicate metabolic stress. Increased blood HSP70 mRNA in physically active men may show an alternative apoptosis suppression pathway.Öğe Downregulation of midkine enhances the efficacy of quercetin on androgen-sensitive prostate cancer stem cell survival through arresting cell cycle and inducing apoptosis(Wiley, 2018) Erdogan, S.; Turkekul, K.; Serttas, R.; Doganlar, Z. B.; Doganlar, O.; Dibirdik, I.; Bilir, A.[Abstract Not Available]Öğe The flavonoid apigenin reduces survival and migration of CD44+prostate cancer stem cells(Wiley-Blackwell, 2016) Erdogan, S.; Doganlar, O.; Doganlar, Z. B.; Serttas, R.; Turkekul, K.; Dibirdik, I.; Bilir, A.[Abstract Not Available]Öğe Genotoxic effect of multigenerational Cd exposure in Drosophila melanogaster: Expressions of antioxidant enzymes and RAPD-DNA profiles(Elsevier Ireland Ltd, 2016) Ongoren, G.; Doganlar, Z. B.[Abstract Not Available]Öğe Glycyrrhiza glabra protects the liver hepatocytes from the volatile organic compounds(Elsevier Ireland Ltd, 2016) Erdogan, Z.; Erdogan, S.; Doganlar, Z. B.; Doganlar, O.; Canogullari, S.[Abstract Not Available]Öğe Intranasal miRNAs-17/20 Administration Alleviates Early Brain Injury After Subarachnoid Hemorrhage in Rats(Springer, 2023) Malcok, U. A.; Doganlar, O.; Tufekcioglu, N. K.; Ovali, M. A.; Aykora, D.; Doganlar, Z. B.; Buyuk, B.Early brain injury (EBI) in the first 24-72 h is the leading cause of mortality and disability related to subarachnoid hemorrhage (SAH). Both melatonin and microRNAs (miRs) are involved in the regulation of a number of neuronal molecular signaling procedures in the central nervous system, ranging from hypoxia, inflammation to neuronal apoptosis. The present study was performed to explore the effect of miRs-17/20 and combined treatment with melatonin on early brain injury after SAH and underlying molecular mechanisms in rats. In this study 54 Wistar albino rats were divided into six experimental groups: Sham, SAH, SAH + Melatonin, SAH+miRs-17/20 control, SAH+MEL+miRs-17/20, and SAH+MEL+miRs-17/20. The Garcia's Neurological Scoring Scale and motor coordination tests were used for clinical observation. H&E staining was performed to evaluate pathological score. The gene expression levels were determined by qRT-PCR and key proteins were quantitated by Western blot assay. miRs-17/20 with or without melatonin treatment suppressed the expression and activity of both the HIF1/VEGF/MMPs and the IL6R/JAK2/STAT3 axis. miRs-17/20 with or without melatonin treatment also mitigated the clinical impairment, pyknosis, and edema in the hippocampus and cortex and neurodegeneration induced by SAH. Our results show that miRs-17/20 alleviated EBI by reducing hypoxic conditions, hypoxia-induced molecular signaling, and neuronal apoptosis.Öğe Myricetin induces apoptosis in HeLa cells: A time and dose dependent study(Elsevier Ireland Ltd, 2016) Tabakcioglu, K.; Doganlar, Z. B.; Doganlar, O.; Erdogan, S.; Ongoren, G.[Abstract Not Available]Öğe Protective role of melatonin against caspase depended apoptosis in thoracic aorta tissue of pinealectomised rat(Wiley, 2017) Doganlar, Z. B.; Doganlar, O.; Uzun, M.; Ovali, M. A.; Ongoren, G.[Abstract Not Available]Öğe Seasonal variation of pesticide accumulation and heat shock protein expressions in blood of people live in monoculture rice farming area in Edirne-Turkiye(Elsevier Ireland Ltd, 2016) Doganlar, Z. B.; Doganlar, O.; Dogan, A.; Gokalp, F. D.; Kahraman, O.; Tozkir, H.; Askin, O. O.[Abstract Not Available]Öğe Single and combined toxicity of aluminum and azorubine: Physiological and genetic responses of Drosophila melanogaster(Elsevier Ireland Ltd, 2016) Doganlar, Z. B.; Doganlar, O.; Ongoren, G.; Mimiroglu, P. A.; Kahraman, O.; Soykan, A.; Sari, A.[Abstract Not Available]
