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    Experimental high dose radioactive I-131 ablation model in guinea pig
    (Springer, 2009) Torun, N.; Ergulen, A.; Dirlik, B.; Durmus-Altun, G.
    [Abstract Not Available]
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    The fibrotic changes in lung tissue increased the SUVmax values on F-18 FDG PET/CT
    (Springer, 2011) Torun, N.; Dirlik, B.; Durmus-Altun, G.
    [Abstract Not Available]
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    Pulmonary microvascular permeability and gas exchange in patients with syndrome X
    (Lithographia, 2012) Durmus-Altun, G.; Vardar, S. A.; Salihoglu, Y. S.; Aktoz, M.; Dirlik, B.; Altun, A.
    Aim: This clinical study was planned to assess pulmonary microvascular permeability in patients with Syndrome X (SX) by using a functional imaging tool, technetium-99m-diethyltriaminepentaaceticacid (Tc-99m-DTPA) lung clearance scintigraphy, and the pulmonary functions test, which includes diffusion capacity of the lung for carbon monoxide (DLCO). Methods: The study population consisted of 22 non-smoker subjects divided into two groups. First group comprised 12 patients (4 male, 8 female, mean age: 48 +/- 4 years, range 36 to 65) with SX. Ten healthy subject (4 men, 6 female, mean age: 45 +/- 3 years, range 34 to 58) were served as control group. Volumetric pulmonary functions, including DLCO were also performed before lung scintigraphy. Alveolar epithelial permeability was assessed by measuring the pulmonary clearance of an inhaled Tc-99m-DTPA using a gamma camera. Results: Spirometric data was comparable in both groups. Although volumetric pulmonary measurements were similar, DLCO values of SX patients were lower than those in control (20.9 +/- 1.7 ml/min/mmHg vs. 27.8 +/- 1.3 ml/min/mmHg, p=0.002). The mean clearance rate of Tc-99m-DTPA in control subjects was 106 +/- 6 min, and this value was lower than patients with SX (179 +/- 19 min; p=0.0001). Conclusion: We conclude that lung is a target organ for SX. The pulmonary gas exchange and microvascular permeability, which is measured by 99mTc-DTPA scintigraphy, are restricted without change of volumetric pulmonary functions in patients with SX. Hippokratia 2012; 16 (2): 113-117
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    Scintigraphic evaluation of small intestinal transit in the streptozotocin induced diabetic rats
    (Lithographia, 2011) Durmus-Altun, G.; Vatansever, U.; Arzu, Vardar S.; Altaner, S.; Dirlik, B.
    Aim: Small intestine (SI) transit in the streptozotocin (STZ) induced diabetic rats were examined by using 99mTc-mebrofenin scintigraphy. Materials and methods: Wistar albino rats (mean body weight: 220 +/- 12 g) were studied for both control (n=10) and diabetes mellitus (DM) (n=10) groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg kg(-1) body weight. SI transit time was assessed by measuring arrival times of 99mTc-mebrofenin from duodenum to caecum. Results: The mean transit time of 99mTc-mebrofenin was 67.8 +/- 11 min in control group. The mean transit time of SI was prolonged in STZ induced diabetic animals with (111.9 +/- 12.5, p=0.01). There was significant correlation between small intestinal transit time and blood glucose level (r: 0.73, p=0.01). Conclusion: We observed that SI transit was prolonged in diabetic animals using 99mTc-mebrofenin, and additionally this technique is a readily available method for the detection of transit abnormalities in animal experiment. Hippokratia 2011; 15 (3): 262-264