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    Can radiation-induced chronic oxidative stress in kidney and liver be prevented by dimethylsulfoxide? Biochemical determination by serum and tissue markers
    (Imprimatur Publications, 2012) Cosar, R.; Eskiocak, S.; Caloglu, V. Yurut; Ozen, A.; Uzal, C.; Caloglu, M.; Ibis, K.
    Purpose: To investigate the protective effects of dimethylsulfoxide (DMSO) on chronic oxidative stress in the liver, kidney and serum with biochemical parameters such as malondialdehyde (MDA), advanced oxidation protein product (AOPP), catalase, glutathione (GSH), and free-thiols (F-SW. Methods: Thirty Wistar albino female rats were randomly divided into 3 groups: group [(control, n=10), group H (irradiation-alone group, n=10) and group III (DMSO and irradiation group, n=10). Rats in groups II and III were irradiated with a single dose of 6 Gy to the entire liver and right kidney. Group III received DMSO 4.5 g/kg by intraperitoneal injection 30 min before irradiation. At the end of the 24th week, the rats were sacrificed and their trunk blood, kidney and liver tissues were collected. Results: Group II rats showed increased levels of lipid peroxidation and protein oxidation, with decreased GSH, F-SH and catalase levels in all specimens when compared with group I. Serum and kidney MDA and AOPP levels were significantly lower in group III when compared with group II. However, serum and kidney GSH and F-SH levels were significantly higher in group III when compared with group II. The additive effect on catalase was seen only in the serum. Conclusion: DMSO is a protective agent on chronic oxidative stress in the serum and kidney tissue. No oxidant or antioxidant effect of DMSO in the liver was seen.
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    Can Radiation-Induced Chronic-Oxidative Stress in Kidney and Liver Be Prevented by Dimethyl Sulfoxide? Biochemical Determination by Serum and Tissue Markers
    (Elsevier Sci Ltd, 2011) Cosar, R.; Eskiocak, S.; Yurut-Caloglu, V.; Ozen, A.; Uzal, C.; Caloglu, M.; Ibis, K.
    [Abstract Not Available]
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    The effect of gender differences on radiation induced acute lung toxicity by using XRCC1, XRCC3 and HHR2L gene panel
    (Elsevier Ireland Ltd, 2015) Ozen, A.; Cakina, S.; Turkkan, G.; Cosar, R.; Sipahi, T.; Kocak, Z.; Uzal, C.
    [Abstract Not Available]
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    EVALUATION OF BRCA 1-2 GENE MUTATIONS IN PATIENTS WITH TRIPLE NEGATIVE AND ER(-), PR(-), HER-2(+) BREAST CANCER
    (Elsevier Ireland Ltd, 2011) Uzal, M. C.; Sener, S.; Ozen, A.; Cakina, S.; Sipahi, T.; Cosar, R.; Gulyasar, T.
    [Abstract Not Available]
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    Investigation of cardiac and pulmonar doses in patients with left sided breast cancer treated by radiotherapy with deep inspiration breath hold technique
    (Ijrr-Iranian Journal Radiation Res, 2022) Parlar, S.; Var, G.; Cosar, R.; Dogan, M.; Ozguven, Y.; Nurlu, D.; CemUzal, M.
    Background: Cardiac disease is a documented risk factor in left breast irradiation. In an attempt to reduce cardiac toxicity, different treatment techniques adapted to respiratory cycle phases have been developed. The aim of this study is to investigate the feasibility of the voluntary breath hold technique when irradiating the left breast in selected patients. Material and Methods: The study included 20 patients with left sided breast cancer. For each patient, two computed tomography (CT) scans were acquired, one with the free breathing (FB) technique and one with the voluntary deep inspiration breath hold (DIBH) technique. Treatment plans were created using a field-in-field intensity-modulated radiation therapy technique. A dosimetric comparison was made between the two techniques for the heart, left anterior descending (LAD) coronary artery, ipsilateral lung and contralateral breast. Results: The average of the mean dose of the heart decreased from 7.7 Gy to 5.8 Gy and V-20(Gy) (%) from 12.8% to 8.3% using the DIBH technique (p=0.009, p<0.001). The DIBH technique demonstrated significantly smaller maximum heart distance (2.0 cm vs. 0.9 cm, p < 0.001) and 8.0% reduction in LAD mean dose. Furthermore, D-mean for the ipsilateral lung was reduced from 12.8 Gy to 12.2 Gy and V-20(Gy) (%) from 25.6% to 22.8%. Conclusion: In the treatment plans made using the DIBH technique, a significant reduction in the radiation dose delivered to the heart has been observed. In order to reduce long-term morbidity and mortality risks from cardiovascular disease affecting the survival of patients with left sided breast cancer, irradiation techniques such as the DIBH should be considered, especially for premenopausal patients.