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Öğe High plasma d-dimer level is associated with decreased survival in patients with lung cancer(Elsevier Science London, 2007) Altiay, G.; Ciftci, A.; Demir, M.; Kocak, Z.; Sut, N.; Tabakoglu, E.; Hatipoglu, O. N.Aims: An elevated plasma D-dimer level indicates the activation of coagulation and fibrinolysis. In the present study, we investigated the association of pre-treatment haemostatic parameters (D-dimer, fibrinogen and prothrombin fragment 1 + 2) with clinicopathological parameters and outcome in patients with lung cancer. Materials and methods: Plasma levels Of D-dimer and other parameters were measured in 78 evaluable patients with lung cancer (60 non-small cell lung cancers, 18 small cell lung cancers). At diagnosis, 35 patients (44.9%) were locally advanced stage (IIIA/B) and 43 patients (55.1%) had metastatic disease (IV). Multivariate statistical analysis was carried out using Cox's proportional hazards model. The receiver operating characteristic curve was used to determine the cutoff values for D-dimer, fibrinogen and prothrombin fragment 1 + 2. Results: The median survival for all patients was 264 days (95% confidence interval 200-328 days). A significant association between the plasma levels Of D-dimer and the response to chemotherapy was observed (P = 0.03). With the univariate analysis, tumour stage, pre-treatment plasma levels Of D-dimer, fibrinogen, platelet count, lactate dehydrogenase concentration and Karnofsky performance status were predictive for survival. With the multivariate analysis (P <= 0.11), the plasma level Of D-dimer (P < 0.001), tumour stage (P = 0.01) and Karnofsky performance status (P = 0.02) were identified as independent predictive factors. The median survival times were 405 days (95% confidence interval 165-644 days) and 207 days (95% confidence interval 146-267 days, P < 0.001), respectively, for patients with a low D-dimer level (<= 0.65 mu g/ml) and a high D-dimer level (> 0.65 mu g/ml). Conclusions: Elevated plasma levels Of D-dimer in patients with lung cancer are associated with decreased survival and a poor response to treatment. Pre-treatment for the D-dimer level may be useful in the prediction of survival and the response to treatment.Öğe ProteinChip array profiling and markers of inflammation and thrombin generation in plasma samples from lung cancer patients and their modulation by chemotherapy with or without warfarin anticoagulation(Amer Soc Hematology, 2007) Demir, Muzaffer; Ciftci, A.; Hoppensteadt, Debra; Altiay, G.; Tobu, Mahennut; Iqbal, Omer; Fareed, Dan[Abstract Not Available]Öğe Up-regulation of inflammatory and thrombotic mediators in lung cancer and their modulation by oral anticoagulantion(Amer Soc Clinical Oncology, 2007) Fareed, J.; Ciftci, A.; Demir, M.; Hoppensteadt, D.; Altiay, G.; Tobu, M.; Iqbal, O.[Abstract Not Available]
